Protein Alignment Hsp70Bc and Hspa4l

DIOPT Version :10

• Sequence 1: NP_650209.1
• Gene: Hsp70Bc / 48583
• FlyBaseID: FBgn0013279
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_001099898.2
• Gene: Hspa4l / 294993
• RGDID: 1306528
• Length: 838
• Species: Rattus norvegicus
• Alignment Length: 704
• Identity: 197/704 - (27%)
• Similarity: 342/704 - (48%)
• Gaps: 101/704 - (14%)

  Fly     1 MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVF 65
            |..:|||||.....:.|.:.|.:|.|||:..:|.||:.::.....|.||:.||:|:..|.|||:.
  Rat     1 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIH 65

  Fly    66 DAKRLIGRKYDDPKIAEDMKHWPFKVVS-DGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAE 129
            ..|:|.||.:|||.:..:....|:::.. ..|...:.|.|..|.:.||.|:::.|:|.|:|||:|
  Rat    66 GFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLKETSE 130

  Fly   130 AYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKN-----LKGE 189
            ..|.:.:.|.||::|::|.|::|::...|..:||||.||::||.||.|||||:.|.     .:..
  Rat   131 NALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPSLDEKP 195

  Fly   190 RNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSN 254
            |||:..|:|...:.||:...::|.| :|.:|..|.:|||.:||..||.:..:|||.|||.:::.|
  Rat   196 RNVVFIDMGHSAYQVSVCAFNKGKL-KVLATTFDPYLGGRNFDEALVDYFCDEFKAKYKINVKEN 259

  Fly   255 PRALRRLRTAAERAKRTLS-SSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKA 318
            .|||.||....|:.|:.:| ::::..:.|:......|..:|::||:||:|||.|......|::..
  Rat   260 SRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAV 324

  Fly   319 LNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQS 383
            ::.|.:.:..|:.|.:|||:||||.|:..:..||. |:::.::|.|||||.|.|:|.||||  .:
  Rat   325 MDQANLQREDINSIEIVGGATRIPAVKEQVTRFFL-KDISTTLNADEAVARGCALQCAILS--PA 386

  Fly   384 GKIQDVLLVDVAPLSLGIE-----TAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEG 443
            .|:::..:.|:.|.|:.:.     ..|....::..:|...|..:..||   ...:|......|..
  Rat   387 FKVREFSITDLVPYSVTLSWKTSFEEGTGECEVFSKNHPAPFSKVITF---HKKEPFELEAFYTN 448

  Fly   444 ERAMTKDNNALGTFDLSGIPPAPRG-VPQIEVTFDLDANGILNVSAKEM---------------- 491
            ...:...:..:|.|.:..:.|...| ..:::|...::.:||.:|::..:
  Rat   449 LHEVPYPDPRIGNFTIQNVFPQSDGDSSKVKVKVRINIHGIFSVASASVIEKQNLEGDHNDAPME 513

  Fly   492 --------------------------------------STG-KAK----------NITIKNDK-- 505
                                                  .|| |||          |.|||..|
  Rat   514 TEASKNEGKEDVDKMQVDQEEGGHQKCHAEHTPEEEIDHTGAKAKAPPSDKQDRINQTIKKGKIK 578

  Fly   506 -----------GRLSQAEIDRMVNEAEKYADEDEKHRQRITSRNALESYVFNVKQSVEQAPAGKL 559
                       .:|:|..::..:....|...:|:..::|..::||:|.||::.:..:.......:
  Rat   579 SIDLPIQSSLYRQLTQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDKLGTVYEKFI 643

  Fly   560 DEADKNSVLDKCNETIRWL-DSNTTAEKEEFDHKMEELTRHCSPIMTKM--HQQ 610
            ...|.|.:.....:|..|| :......|:.:..|::||.::..||..|.  |::
  Rat   644 TPEDMNKLSAMLEDTENWLYEEGEDQPKQVYVDKLQELKKYGQPIQMKYVEHEE 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Bc	NP_650209.1	PTZ00009	2..641	CDD:240227	196/703 (28%)
Hspa4l	NP_001099898.2	ASKHA_NBD_HSP70_HSPA4L	2..384	CDD:466844	142/383 (37%)