DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hsp70Bc and Hspa4

DIOPT Version :9

Sequence 1:NP_650209.1 Gene:Hsp70Bc / 48583 FlyBaseID:FBgn0013279 Length:641 Species:Drosophila melanogaster
Sequence 2:NP_032326.3 Gene:Hspa4 / 15525 MGIID:1342292 Length:842 Species:Mus musculus


Alignment Length:830 Identity:225/830 - (27%)
Similarity:358/830 - (43%) Gaps:207/830 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVF 65
            |..:|||||.....|.|.:.|.:|.|||:..:|.||:.|:|....|.||..||:||..|.:|||.
Mouse     1 MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPKNRSIGAAAKSQVISNAKNTVQ 65

  Fly    66 DAKRLIGRKYDDPKIAEDMKHWPFKVVS-DGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAE 129
            ..||..||.:.||.:..:..:..:.:|. ..|...|.|.|..|.:.|..|::::|:|:|:|||||
Mouse    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130

  Fly   130 AYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKN-----LKGE 189
            :.|.:.:.|.|::||:::.|::|::..||..|||||.||::||.||.|||||:.|.     .:..
Mouse   131 SVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195

  Fly   190 RNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSN 254
            |||:..|:|...:.||:...::|.| :|.:||.||.|||..||..||.|..|||.:|||.|::|.
Mouse   196 RNVVFVDMGHSAYQVSVCAFNKGKL-KVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSK 259

  Fly   255 PRALRRLRTAAERAKRTLS-SSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKA 318
            .|||.||....|:.|:.:| ::::..:.|:......|....::|.:|.|:|.||......|:...
Mouse   260 IRALLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDDLLARVEPPLRSV 324

  Fly   319 LNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQS 383
            |..:|:.|..|:.:.:|||:||||.|:..:.:|| ||.|:.::|.||||..|.|:|.||||  .:
Mouse   325 LEQSKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGCALQCAILS--PA 386

  Fly   384 GKIQDVLLVDVAPLSLGIETAGGVMTKLIERNCRI-PCKQTKTFS---TYSDNQPGVSIQVYEGE 444
            .|:::..:.||.|..:.:.........|  .:|.: |......||   |:...:|......|...
Mouse   387 FKVREFSITDVVPYPISLRWNSPAEEGL--SDCEVFPKNHAAPFSKVLTFYRKEPFTLEAYYSSP 449

  Fly   445 RAMTKDNNALGTFDLSGIPPAPRG-VPQIEVTFDLDANGILNVS--------------------- 487
            :.:...:.|:..|.:..:.|...| ..:::|...::.:||.:||                     
Mouse   450 QDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHKSEESEEPMETDQ 514

  Fly   488 ---------------------------------AKEMSTGKAKNITIKND------KGRLSQAEI 513
                                             ::||.|.:|.:...|.|      |.::..:.:
Mouse   515 NAKEEEKMQVDQEEPHTEEQQQQPQTPAENKAESEEMETSQAGSKDKKTDQPPQAKKAKVKTSTV 579

  Fly   514 DRMV------------------NEAEKYADEDEKHRQRITSRNALESYVFNVK------------ 548
            |..:                  ||. |...:|:..::|..::||:|.||:.::            
Mouse   580 DLPIESQLLWQLDREMLGLYTENEG-KMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVS 643

  Fly   549 ------------------------------------------------QSVEQAP-----AGK-- 558
                                                            |..|:.|     .||  
Mouse   644 EDDRNTFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKSLGQPIKTRFQESEERPKLFEELGKQI 708

  Fly   559 -------------------LDEADKNSVLDKCNETIRWLDS------------NTTAEKEEFDHK 592
                               ||.||...|....||.:.|::|            :...:.:|.:.|
Mouse   709 QQYMKVISSFKNKEDQYEHLDAADVTKVEKSTNEAMEWMNSKLNLQNKQSLTVDPVVKTKEIEAK 773

  Fly   593 MEELTRHCSPIMTK------------MHQQGAGAAGGPGANCGQQAGGFG 630
            ::|||..||||::|            .|.:..|...|.|.|.|.||...|
Mouse   774 IKELTSICSPIISKPKPKVEPPKEEPKHAEQNGPVDGQGDNPGSQAAEHG 823

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp70BcNP_650209.1 PTZ00009 2..641 CDD:240227 224/829 (27%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 150/382 (39%)
Hspa4NP_032326.3 HSPA4_NBD 2..384 CDD:212687 150/383 (39%)
HSP70 3..609 CDD:278441 184/612 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 500..577 7/76 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 784..842 11/40 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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