DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp70Bc and Hspa1b

DIOPT Version :9

Sequence 1:NP_650209.1 Gene:Hsp70Bc / 48583 FlyBaseID:FBgn0013279 Length:641 Species:Drosophila melanogaster
Sequence 2:NP_034608.2 Gene:Hspa1b / 15511 MGIID:99517 Length:642 Species:Mus musculus


Alignment Length:648 Identity:492/648 - (75%)
Similarity:555/648 - (85%) Gaps:20/648 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 AIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDA 67
            |||||||||||||||:|||||||||||||||||||||||||:||||||.||||||:||:||||||
Mouse     6 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDA 70

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYL 132
            |||||||:.|..:..|||||||:||:||.|||:.|.|||||:.|.||||||||||||||.|||||
Mouse    71 KRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKMKEIAEAYL 135

  Fly   133 GESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 197
            |..:|:|||||||||||||||||||||.|||||||||||||||||:|||||:..|||||||||||
Mouse   136 GHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDL 200

  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRLR 262
            |||||||||||||:| :|||::|||||||||||||||||:|..||||||:|||:..|.||:||||
Mouse   201 GGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLR 264

  Fly   263 TAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKG 327
            ||.|||||||||||:|::|||:||||.||||.::||||||||:||||.||:||||||.||||||.
Mouse   265 TACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKA 329

  Fly   328 QIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLV 392
            ||||:|||||||||||||.|||:||:|::||.|||||||||||||||||||.||:|..:||:||:
Mouse   330 QIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLL 394

  Fly   393 DVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGTF 457
            ||||||||:||||||||.||:||..||.|||:||:|||||||||.|||||||||||:|||.||.|
Mouse   395 DVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRF 459

  Fly   458 DLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEK 522
            :|||||||||||||||||||:||||||||:|.:.|||||..|||.|||||||:.||:|||.|||:
Mouse   460 ELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAER 524

  Fly   523 YADEDEKHRQRITSRNALESYVFNVKQSVE-QAPAGKLDEADKNSVLDKCNETIRWLDSNTTAEK 586
            |..|||..|.|:.::||||||.||:|.:|| :...|||.||||..|||||.|.|.||||||.|:|
Mouse   525 YKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADK 589

  Fly   587 EEFDHKMEELTRHCSPIMTKMHQQGAGAAGGPGANCGQQAGGFGGY--------SGPTVEEVD 641
            |||.||.|||.|.||||::.:: |||||.|         |||||..        ||||:||||
Mouse   590 EEFVHKREELERVCSPIISGLY-QGAGAPG---------AGGFGAQAPPKGASGSGPTIEEVD 642

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp70BcNP_650209.1 PTZ00009 2..641 CDD:240227 490/646 (76%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 309/375 (82%)
Hspa1bNP_034608.2 PTZ00009 1..642 CDD:240227 490/646 (76%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..386 312/380 (82%)
HSPA1-2_6-8-like_NBD 6..381 CDD:212675 309/375 (82%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 394..509 92/114 (81%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 617..642 12/33 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53894
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100083
Panther 1 1.100 - - LDO PTHR19375
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.820

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