DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hsp70Bb and HSPA4

DIOPT Version :9

Sequence 1:NP_524927.2 Gene:Hsp70Bb / 48582 FlyBaseID:FBgn0013278 Length:641 Species:Drosophila melanogaster
Sequence 2:NP_002145.3 Gene:HSPA4 / 3308 HGNCID:5237 Length:840 Species:Homo sapiens


Alignment Length:828 Identity:225/828 - (27%)
Similarity:358/828 - (43%) Gaps:205/828 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVF 65
            |..:|||||.....|.|.:.|.:|.|||:..:|.||:.::|....|.||..||:||..|.:|||.
Human     1 MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNAKNTVQ 65

  Fly    66 DAKRLIGRKYDDPKIAEDMKHWPFKVVS-DGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAE 129
            ..||..||.:.||.:..:..:..:.:|. ..|...|.|.|..|.:.|..|::::|:|:|:|||||
Human    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130

  Fly   130 AYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKN-----LKGE 189
            :.|.:.:.|.|::||.::.|::|::..||..|||||.||::||.||.|||||:.|.     .:..
Human   131 SVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195

  Fly   190 RNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSN 254
            |||:..|:|...:.||:...:.|.| :|.:||.||.|||..||..||.|..|||.:|||.|::|.
Human   196 RNVVFVDMGHSAYQVSVCAFNRGKL-KVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSK 259

  Fly   255 PRALRRLRTAAERAKRTLS-SSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKA 318
            .|||.||....|:.|:.:| ::::..:.|:......|....::|.:|.|:|.||......|:...
Human   260 IRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLEMCNDLLARVEPPLRSV 324

  Fly   319 LNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQS 383
            |...|:.|..|:.:.:|||:||||.|:..:.:|| ||.|:.::|.||||..|.|:|.||||  .:
Human   325 LEQTKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGCALQCAILS--PA 386

  Fly   384 GKIQDVLLVDVAPLSLGIE-----TAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEG 443
            .|:::..:.||.|..:.:.     ..|....::..:|...|..:..||..   .:|......|..
Human   387 FKVREFSITDVVPYPISLRWNSPAEEGSSDCEVFSKNHAAPFSKVLTFYR---KEPFTLEAYYSS 448

  Fly   444 ERAMTKDNNALGTFDLSGIPPAPRG-VPQIEVTFDLDANGILNVS-------------------- 487
            .:.:...:.|:..|.:..:.|...| ..:::|...::.:||.:||                    
Human   449 PQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSASLVEVHKSEENEEPMETD 513

  Fly   488 --------------------------------AKEMSTGKAKNITIKND------KGRLSQAEID 514
                                            ::||.|.:|.:...|.|      |.::..:.:|
Human   514 QNAKEEEKMQVDQEEPHVEEQQQQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVD 578

  Fly   515 -------------RMVN---EAE-KYADEDEKHRQRITSRNALESYVFNVK-------------- 548
                         .|:|   |.| |...:|:..::|..::||:|.||:.::              
Human   579 LPIENQLLWQIDREMLNLYIENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSED 643

  Fly   549 ----------------------------------------------QSVEQAP-----AGK---- 558
                                                          |..|:.|     .||    
Human   644 DRNSFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKNLGQPIKIRFQESEERPKLFEELGKQIQQ 708

  Fly   559 -----------------LDEADKNSVLDKCNETIRWLDS------------NTTAEKEEFDHKME 594
                             ||.||...|....||.:.|:::            :...:.:|.:.|::
Human   709 YMKIISSFKNKEDQYDHLDAADMTKVEKSTNEAMEWMNNKLNLQNKQSLTMDPVVKSKEIEAKIK 773

  Fly   595 ELTRHCSPIMT---------KMHQQGA---GAAGGPGANCGQQAGGFG 630
            |||..||||::         |..|:.|   |...|.|.|.|.||...|
Human   774 ELTSTCSPIISKPKPKVEPPKEEQKNAEQNGPVDGQGDNPGPQAAEQG 821

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp70BbNP_524927.2 PTZ00009 2..641 CDD:240227 224/827 (27%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 149/382 (39%)
HSPA4NP_002145.3 HSPA4_NBD 2..384 CDD:212687 149/383 (39%)
HSP70 3..607 CDD:278441 184/610 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 500..575 7/74 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 779..840 15/43 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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