DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp70Bb and Hspa5

DIOPT Version :9

Sequence 1:NP_524927.2 Gene:Hsp70Bb / 48582 FlyBaseID:FBgn0013278 Length:641 Species:Drosophila melanogaster
Sequence 2:NP_037215.1 Gene:Hspa5 / 25617 RGDID:2843 Length:654 Species:Rattus norvegicus


Alignment Length:619 Identity:380/619 - (61%)
Similarity:486/619 - (78%) Gaps:13/619 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFT-DSERLIGDPAKNQVAMNPRNTVFDA 67
            :|||||||||||||:::|:|||||||||||.|||||||| :.||||||.||||:..||.||||||
  Rat    31 VGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDA 95

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEY-KGESKRFAPEEISSMVLTKMKETAEAY 131
            ||||||.::||.:.:|:|..|||||....||.|.|:. .|::|.|||||||:|||||||||||||
  Rat    96 KRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAY 160

  Fly   132 LGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFD 196
            ||:.:|.||:||||||||:|||||||||.||||||:||||||||||:||||||. :||:|:|:||
  Rat   161 LGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKR-EGEKNILVFD 224

  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRL 261
            |||||||||:||||.| :|||.:|.|||||||||||.|::.|..:.:|:|..||:|.:.||:::|
  Rat   225 LGGGTFDVSLLTIDNG-VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKL 288

  Fly   262 RTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDK 326
            |...|:|||.|||..:|.|||::.|||:||...::||:||||..||||:|::||:|.|.|:.:.|
  Rat   289 RREVEKAKRALSSQHQARIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKK 353

  Fly   327 GQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLL 391
            ..|.:||||||||||||:|.|::|||:||..:..|||||||||||||||.:|||||.  ..|::|
  Rat   354 SDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQD--TGDLVL 416

  Fly   392 VDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGT 456
            :||.||:|||||.||||||||.||..:|.|:::.|||.|||||.|:|:||||||.:||||:.|||
  Rat   417 LDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGT 481

  Fly   457 FDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAE 521
            |||:||||||||||||||||::|.||||.|:|::..||....|||.||:.||:..||:||||:||
  Rat   482 FDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAE 546

  Fly   522 KYADEDEKHRQRITSRNALESYVFNVKQSV--EQAPAGKLDEADKNSVLDKCNETIRWLDSNTTA 584
            |:|:||:|.::||.:||.||||.:::|..:  ::...|||...||.::.....|.|.||:|:..|
  Rat   547 KFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSPEDKETMEKAVEEKIEWLESHQDA 611

  Fly   585 EKEEFDHKMEELTRHCSPIMTKMHQQGAGAAGGP 618
            :.|:|..|.:||.....||::|::     .:|||
  Rat   612 DIEDFKAKKKELEEIVQPIISKLY-----GSGGP 640

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp70BbNP_524927.2 PTZ00009 2..641 CDD:240227 380/619 (61%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 250/376 (66%)
Hspa5NP_037215.1 Required for interaction with KIAA1324. /evidence=ECO:0000250|UniProtKB:P11021 1..80 39/48 (81%)
HSPA5-like_NBD 28..403 CDD:212681 249/373 (67%)
HSP70 30..635 CDD:278441 377/607 (62%)
Nucleotide-binding (NBD). /evidence=ECO:0000250|UniProtKB:P11021 125..280 111/156 (71%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 409..419 3/11 (27%)
Substrate-binding (SBD). /evidence=ECO:0000250|UniProtKB:P11021 420..500 58/79 (73%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..654 4/15 (27%)
Prevents secretion from ER 651..654
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53894
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100083
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.720

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