DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp70Aa and cpHsc70-1

DIOPT Version :9

Sequence 1:	NP_731651.1	Gene:	Hsp70Aa / 48581	FlyBaseID:	FBgn0013275	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_194159.1	Gene:	cpHsc70-1 / 828531	AraportID:	AT4G24280	Length:	718	Species:	Arabidopsis thaliana

Alignment Length:	638	Identity:	309/638 - (48%)
Similarity:	415/638 - (65%)	Gaps:	28/638 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDS-ERLIGDPAKNQVAMNPRNTVFDA 67
            :|||||||.|.|...:.||..|:.|.:|.|||||.||:|.| :||:|..||.|..:||.||.|..
plant    81 VGIDLGTTNSAVAAMEGGKPTIVTNAEGQRTTPSVVAYTKSGDRLVGQIAKRQAVVNPENTFFSV 145

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYL 132
            ||.||||.::  :.|:.|...::||.|... .:.:|....:|:||.||||:.||.|:.:.|..:|
plant   146 KRFIGRKMNE--VDEESKQVSYRVVRDENN-NVKLECPAINKQFAAEEISAQVLRKLVDDASRFL 207

  Fly   133 GESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 197
            .:.:|.||||||||||||||.||||||.||||.|||||||||||:||||.|:  |....:|:|||
plant   208 NDKVTKAVITVPAYFNDSQRTATKDAGRIAGLEVLRIINEPTAASLAYGFDR--KANETILVFDL 270

  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALRRLR 262
            ||||||||:|.:.:| :|||.||:|||||||:|||.|:|..||.|||:....||..:.:||:||.
plant   271 GGGTFDVSVLEVGDG-VFEVLSTSGDTHLGGDDFDKRVVDWLAAEFKKDEGIDLLKDKQALQRLT 334

  Fly   263 TAAERAKRTLSSSTEATIE---IDALFEG-QDFYTKVSRARFEELCADLFRNTLQPVEKALNDAK 323
            .|||:||..|||.|:..:.   |.|..:| :...|.::||:|||||:||......|||.:|.|||
plant   335 EAAEKAKIELSSLTQTNMSLPFITATADGPKHIETTLTRAKFEELCSDLLDRVRTPVENSLRDAK 399

  Fly   324 MDKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQD 388
            :....|.:::|||||||||.||.|::. ..||..|:::||||.||.||||||.:|:||    :.|
plant   400 LSFKDIDEVILVGGSTRIPAVQELVRK-VTGKEPNVTVNPDEVVALGAAVQAGVLAGD----VSD 459

  Fly   389 VLLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEGERAMTKDNNA 453
            ::|:||.|||:|:||.||||||:|.||..:|..:::.|||.||.|..|.|.|.:|||...:||.:
plant   460 IVLLDVTPLSIGLETLGGVMTKIIPRNTTLPTSKSEVFSTAADGQTSVEINVLQGEREFVRDNKS 524

  Fly   454 LGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVN 518
            ||:|.|.||||||||||||||.||:||||||:|||.:..|||.::||| .....|.:.|:|:||.
plant   525 LGSFRLDGIPPAPRGVPQIEVKFDIDANGILSVSAVDKGTGKKQDITI-TGASTLPKDEVDQMVQ 588

  Fly   519 EAEKYADEDEKHRQRITSRNALESYVFNVKQAVEQAPAGKLDEADKNSVLDKCNDTIRWL-DSNT 582
            |||::|.:|::.|..|.::|..:|.|:..::.:::     |.|.....|.:|....::.| |...
plant   589 EAERFAKDDKEKRDAIDTKNQADSVVYQTEKQLKE-----LGEKIPGEVKEKVEAKLQELKDKIG 648

  Fly   583 TAEKEEFDHKLEELTRHCSPIMTKMHQQGAGAGAGGPGANCGQQAGGFGGYSG 635
            :...:|....:..|.:....|...::.|   .|||||||  |...||.|..||
plant   649 SGSTQEIKDAMAALNQEVMQIGQSLYNQ---PGAGGPGA--GPSPGGEGASSG 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	309/638 (48%)
Hsp70Aa	NP_731651.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	199/379 (53%)
cpHsc70-1	NP_194159.1	PLN03184	40..716	CDD:215618	309/638 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810