Protein Alignment Hsp70Aa and Hspa12b

DIOPT Version :9

• Sequence 1: NP_731651.1
• Gene: Hsp70Aa / 48581
• FlyBaseID: FBgn0013275
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_082582.1
• Gene: Hspa12b / 72630
• MGIID: 1919880
• Length: 685
• Species: Mus musculus
• Alignment Length: 650
• Identity: 144/650 - (22%)
• Similarity: 232/650 - (35%)
• Gaps: 204/650 - (31%)

  Fly    25 IIANDQGNRTTPSYVAF---TDSERLI-------GDPAKNQVAMNPRNT--------VFDAKRLI 71
            ::|.|.|  ||.|..||   :|.|.:.       |||.   ||.....|        :|.:....
Mouse    62 VVAIDFG--TTSSGYAFSFASDPEAIHMMRKWEGGDPG---VAHQKTPTCLLLTPEGIFHSFGYT 121

  Fly    72 GRKYD---DPKIAEDMKHW-PFKV----VSD----------GGKPKIGVEYKGESKRFAPEEISS 118
            .|.|.   ||:.|.|..:: .||:    .:|          .||..:.:|....:.||..|.
Mouse   122 ARDYYHDLDPEEARDWLYFEKFKMKIHSATDLTLKTQLEAVNGKKMLALEVFAHALRFFKEH--- 183

  Fly   119 MVLTKMKETAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGL------NVLRIINEPTAAA 177
             .|.:::|.:|..|.:.....|:||||.:....:|..::|.::|||      ..|.|..||.||:
Mouse   184 -ALQELREQSECMLEKGAVRWVLTVPAIWKQPAKQFMREAAYLAGLVSREDAEKLLIALEPEAAS 247

  Fly   178 L-------------------------AYGLDKNLKGERNVL------------------------ 193
            :                         ...:|.:.:..|..|
Mouse   248 VYCRKLRLHQLMDLSSRTAGRGRLGERRSIDSSFRHAREQLRRSRHSRTFLVEAGVGELWAEMQE 312

  Fly   194 -----IFDLGGGTFDVSILTIDE--GSLFEV-RSTAGDTHLGGED--FDNRLVTHLADEFKRKYK 248
                 :.|.||||.|:::..:::  |:|.|: :::.|.....|.|  |:..|.....::|..|:|
Mouse   313 GDRYMVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDFIAKFK 377

  Fly   249 KDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFE------------ 301
               |..|.|...|..|.|..|||........:.|...|...|||.|......|
Mouse   378 ---RQRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETALRRSSVNLVK 439

  Fly   302 -----------ELCADLFRNT----LQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQDF 351
                       |...:||:.|    :|.:|..|  ||.:...:..:.||||......:|..:|:.
Mouse   440 WSSQGMLRMSCEAMNELFQPTVSGIIQHIEMLL--AKPEVQGVKLLFLVGGFAESAVLQHAVQEA 502

  Fly   352 FHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLVDVAPLSLGIETAGGVMT------- 409
            ...:.|.:.:..|..:   ..::.|:|.|...|    |:.|..:||:.|:    ||:.
Mouse   503 LGTRGLRVVVPHDVGL---TILKGAVLFGQAPG----VVRVRRSPLTYGV----GVLNRFVPGHH 556

  Fly   410 ---KLIERNCRIPCKQTKTFS-----------------TYADNQPG---VSIQVY----EGERAM 447
               ||:.|:.|..|  |..|.                 :|...:||   |.|.:|    |..|.:
Mouse   557 PPEKLLVRDGRRWC--TDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYCCAAEDARFI 619

  Fly   448 T----KDNNAL-------GTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITI 501
            |    :...||       |..:.:|..|:.|.:.......|.:    :.|:|.::||.::....|
Mouse   620 TDPGVRKCGALSLELEPEGCPENTGTSPSRREIRAAMQFGDTE----IKVTAVDVSTNRSVRAAI 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	143/649 (22%)
		HSPA1-2_6-8-like_NBD	3..379	CDD:212675	106/481 (22%)
Hspa12b	NP_082582.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50
		NBD_sugar-kinase_HSP70_actin	61..529	CDD:302596	107/483 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810