Protein Alignment Hsp70Aa and HSPA2

DIOPT Version :9

• Sequence 1: NP_731651.1
• Gene: Hsp70Aa / 48581
• FlyBaseID: FBgn0013275
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_001374860.1
• Gene: HSPA2 / 3306
• HGNCID: 5235
• Length: 639
• Species: Homo sapiens
• Alignment Length: 644
• Identity: 478/644 - (74%)
• Similarity: 549/644 - (85%)
• Gaps: 13/644 - (2%)

  Fly     2 PAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFD 66
            ||||||||||||||||:|||||||||||||||||||||||||:||||||.|||||||||.||:||
Human     6 PAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFD 70

  Fly    67 AKRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAY 131
            ||||||||::|..:..|||||||:|||:|||||:.||||||:|.|.||||||||||||||.||||
Human    71 AKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEIAEAY 135

  Fly   132 LGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKN--LKGERNVLI 194
            ||..:..|||||||||||||||||||||.|.|||||||||||||||:||||||.  ..||:||||
Human   136 LGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLI 200

  Fly   195 FDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALR 259
            |||||||||||||||::| :|||:||||||||||||||||:|:|||:|||||:|||:..|.||:|
Human   201 FDLGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVR 264

  Fly   260 RLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKM 324
            |||||.|||||||||||:|:||||:|:||.||||.::|||||||.|||||.||:||||||.|||:
Human   265 RLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKL 329

  Fly   325 DKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDV 389
            |||||.:||||||||||||:|.||||||:||.||.|||||||||||||||||||.||:|..:||:
Human   330 DKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDL 394

  Fly   390 LLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEGERAMTKDNNAL 454
            ||:||.||||||||||||||.||:||..||.|||:||:||:|||..|.:||||||||||||||.|
Human   395 LLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLL 459

  Fly   455 GTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNE 519
            |.|||:|||||||||||||||||:||||||||:|.:.||||...|||.|||||||:.:|||||.|
Human   460 GKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQE 524

  Fly   520 AEKYADEDEKHRQRITSRNALESYVFNVKQAVE-QAPAGKLDEADKNSVLDKCNDTIRWLDSNTT 583
            ||:|..|||.:|.|:.::||||||.:|:||.|| :...||:.|.|||.:||||.:.|.|||.|..
Human   525 AERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQM 589

  Fly   584 AEKEEFDHKLEELTRHCSPIMTKMHQQGAGAGAGGPGANCGQQAGGFGGYSGPTVEEVD 642
            |||:|::||.:||.|.|:||::|::|.|.|.|:||         ||.|...|||:||||
Human   590 AEKDEYEHKQKELERVCNPIISKLYQGGPGGGSGG---------GGSGASGGPTIEEVD 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	476/642 (74%)
		HSPA1-2_6-8-like_NBD	3..379	CDD:212675	308/377 (82%)
HSPA2	NP_001374860.1	PTZ00009	2..615	CDD:240227	462/609 (76%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..389		312/383 (81%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	397..512		88/114 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..639		14/34 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720