DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp70Aa and Hsph1

DIOPT Version :9

Sequence 1:	NP_731651.1	Gene:	Hsp70Aa / 48581	FlyBaseID:	FBgn0013275	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_001011901.1	Gene:	Hsph1 / 288444	RGDID:	1311609	Length:	858	Species:	Rattus norvegicus

Alignment Length:	730	Identity:	211/730 - (28%)
Similarity:	343/730 - (46%)	Gaps:	142/730 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVF 65
            |..:|:|:|:....:.|.:.|.:|.|||:..:|.|||.::|....|.||..||||...:..|||.
  Rat     1 MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGPKNRTIGVAAKNQQITHANNTVS 65

  Fly    66 DAKRLIGRKYDDPKIAEDMKHWPFKVV--SDGGKPKIGVE--YKGESKRFAPEEISSMVLTKMKE 126
            ..||..||.::||.|.::.::..:.:|  .:||   :|::  |..|...|:.|:|::|:|||:||
  Rat    66 SFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGG---VGIKVMYMDEDHLFSVEQITAMLLTKLKE 127

  Fly   127 TAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDK----NLK 187
            |||..|.:.:||.||:||::|.|::|::..||..|.|||.||::|:.||.||.||:.|    |..
  Rat   128 TAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNAD 192

  Fly   188 GERNVLIF-DLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDL 251
            .:..|::| |:|..:|.||....::|.| :|..||.|..|||::||.:||.|...|||.|||.|.
  Rat   193 EKPRVVVFVDMGHSSFQVSACAFNKGKL-KVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDA 256

  Fly   252 RSNPRALRRLRTAAERAKRTLSS-STEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPV 315
            :|..|||.||....|:.|:.:|| ||:..:.|:.....:|...|::|::||||||:|.:....|:
  Rat   257 KSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSAKMNRSQFEELCAELLQKIEVPL 321

  Fly   316 EKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSG 380
            ...:....:...::..|.:|||:||||.|:..:..|| ||:::.::|.|||||.|.|:|.||||
  Rat   322 HLLMEQTHLKTEEVSAIEIVGGATRIPAVKERIARFF-GKDVSTTLNADEAVARGCALQCAILS- 384

  Fly   381 DQSGKIQDVLLVDVAPLSLGI-------ETAGGVMTKLIERNCRIPCKQTKTF---------STY 429
             .:.|:::..:.|..|..:.:       ||.|  :.::..||...|..:..||         :.|
  Rat   385 -PAFKVREFSVTDAVPFPISLVWNHDSEETEG--VHEVFSRNHAAPFSKVLTFLRRGPFELEAFY 446

  Fly   430 ADNQPGVSIQVYEGERAMTKDNNALGTFDLSGIPPAPRG-VPQIEVTFDLDANGILNVSAKEM-- 491
            :|.|            |:......:|.|.:..:.....| ..:::|...::.:||..:|...|
  Rat   447 SDPQ------------AVPYPEAKIGRFVVQNVSAQKDGEKSKVKVKVRVNTHGIFTISTASMVE 499

  Fly   492 -------------------------STGKAKNITIKN-DKGRLSQAEID-----------RMVNE 519
                                     |:...|||...| :.|...|.:.|           .:.:|
  Rat   500 KVPTEEEDGSSVEADMECPNQKPAESSDVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSE 564

  Fly   520 AEKYADEDEKHRQRI---------------------------TSRNALESYV------------- 544
            ..|..|.|:.:.:::                           ..|:.|..|:
  Rat   565 ENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLE 629

  Fly   545 ---FNVKQAVEQ----------APAGK-LDEADKNSVLDKCNDTIRWL-DSNTTAEKEEFDHKLE 594
               .:.|.|||:          .|..| :.|.:....|....:|..|| :......|:.:..|||
  Rat   630 KERNDAKNAVEECVYEFRDKLCGPYEKFICEQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLE 694

  Fly   595 ELTRHCSPIMTKMHQ 609
            ||.:..:|:..:..:
  Rat   695 ELMKMGTPVKVRFQE 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	210/729 (29%)
Hsp70Aa	NP_731651.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	152/385 (39%)
Hsph1	NP_001011901.1	HSPH1_NBD	2..384	CDD:212689	152/386 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..585		12/84 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..858
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810