DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp70Aa and ssc1

DIOPT Version :9

Sequence 1:	NP_731651.1	Gene:	Hsp70Aa / 48581	FlyBaseID:	FBgn0013275	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_593459.1	Gene:	ssc1 / 2543026	PomBaseID:	SPAC664.11	Length:	674	Species:	Schizosaccharomyces pombe

Alignment Length:	632	Identity:	292/632 - (46%)
Similarity:	414/632 - (65%)	Gaps:	45/632 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFT-DSERLIGDPAKNQVAMNPRNTVF 65
            |.||||||||.||:.:.:....::|||.:|.|||||.|||| |.|||:|..||.|..:||.||.|
pombe    51 PVIGIDLGTTTSCLAIMEGQTPKVIANAEGTRTTPSVVAFTKDGERLVGVSAKRQAVINPENTFF 115

  Fly    66 DAKRLIGRKYDDPKIAEDMKHWPFKVV--SDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETA 128
            ..||||||::.:|::..|:|..|:|:|  |:|   ...:|.:|  |.::|.:|...:|:||:|||
pombe   116 ATKRLIGRRFKEPEVQRDIKEVPYKIVEHSNG---DAWLEARG--KTYSPSQIGGFILSKMRETA 175

  Fly   129 EAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVL 193
            ..|||:.:.:||:|||||||||||||||.||.||||||||::||||||||||||||  |.:..|.
pombe   176 STYLGKDVKNAVVTVPAYFNDSQRQATKAAGAIAGLNVLRVVNEPTAAALAYGLDK--KNDAIVA 238

  Fly   194 IFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRAL 258
            :|||||||||:|||.::.| :||||||.|||||||||||..||.|:.:.||:....||..:..|:
pombe   239 VFDLGGGTFDISILELNNG-VFEVRSTNGDTHLGGEDFDVALVRHIVETFKKNEGLDLSKDRLAV 302

  Fly   259 RRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYT-----------KVSRARFEELCADLFRNTL 312
            :|:|.|||:||..|||.::..|.:       .|.|           ::|||:||:|...|.|.|:
pombe   303 QRIREAAEKAKCELSSLSKTDISL-------PFITADATGPKHINMEISRAQFEKLVDPLVRRTI 360

  Fly   313 QPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAI 377
            .|.::||.||.:...:|::::||||.||:|:|...::..|..:... |:|||||||.|||:|..:
pombe   361 DPCKRALKDANLQTSEINEVILVGGMTRMPRVVETVKSIFKREPAK-SVNPDEAVAIGAAIQGGV 424

  Fly   378 LSGDQSGKIQDVLLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYE 442
            |    ||.::|::|:||.||||||||.|||.|:||.||..||.::::.|||.||.|..|.|:|::
pombe   425 L----SGHVKDLVLLDVTPLSLGIETLGGVFTRLINRNTTIPTRKSQVFSTAADGQTAVEIRVFQ 485

  Fly   443 GERAMTKDNNALGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGR 507
            |||.:.:||..:|.|.|:||.|||:|.|||||:||:||:||:||||::.:|.|..:||:....|
pombe   486 GERELVRDNKLIGNFQLTGIAPAPKGQPQIEVSFDVDADGIINVSARDKATNKDSSITVAGSSG- 549

  Fly   508 LSQAEIDRMVNEAEKYADEDEKHRQRITSRNALESYVFNVKQAVEQAPAGKLDE---ADKNSVLD 569
            |:.:||:.||.:||||...|...::.|.:.|..||...:::..:: ....|||:   .|..|.:.
pombe   550 LTDSEIEAMVADAEKYRASDMARKEAIENGNRAESVCTDIESNLD-IHKDKLDQQAVEDLRSKIT 613

  Fly   570 KCNDTIRWL---DSNTTAE--KEEFDHKLEELTRHCSPIMTKMHQQG 611
            ...:|:..:   |...|:|  |::.| ::::|:......:.|...||
pombe   614 DLRETVAKVNAGDEGITSEDMKKKID-EIQQLSLKVFESVYKNQNQG 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	292/632 (46%)
Hsp70Aa	NP_731651.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	194/389 (50%)
ssc1	NP_593459.1	dnaK	49..671	CDD:234715	292/632 (46%)
ssc1	NP_593459.1	HSPA9-like_NBD	49..425	CDD:212683	195/389 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900