DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp70Aa and ssa2

DIOPT Version :9

Sequence 1:	NP_731651.1	Gene:	Hsp70Aa / 48581	FlyBaseID:	FBgn0013275	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_588421.1	Gene:	ssa2 / 2539225	PomBaseID:	SPCC1739.13	Length:	647	Species:	Schizosaccharomyces pombe

Alignment Length:	646	Identity:	453/646 - (70%)
Similarity:	531/646 - (82%)	Gaps:	8/646 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDA 67
            :|||||||||||||.:.:.:|||||||||||||||||||||:||||||.|||||||||.||:|||
pombe     4 SIGIDLGTTYSCVGHFSNNRVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPHNTIFDA 68

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYL 132
            |||||||:|||::..|||||||||:|..|||.:.||||||:|.|.|||||||||.||:|||||||
pombe    69 KRLIGRKFDDPEVQSDMKHWPFKVISKDGKPVLQVEYKGETKTFTPEEISSMVLMKMRETAEAYL 133

  Fly   133 GESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 197
            |..:||||:||||||||||||||||||.|||||||||||||||||:|||||::.:||.|||||||
pombe   134 GGKVTDAVVTVPAYFNDSQRQATKDAGLIAGLNVLRIINEPTAAAIAYGLDRSNQGESNVLIFDL 198

  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALRRLR 262
            ||||||||:|||:|| :|||::|||||||||||||:|||.|...|||||.|||:..|.||:||||
pombe   199 GGGTFDVSLLTIEEG-IFEVKATAGDTHLGGEDFDSRLVNHFIQEFKRKNKKDITGNARAVRRLR 262

  Fly   263 TAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKG 327
            ||.||||||||||.:|:||||:||||.||||.::|||||||||||||.|::|||:.|.|:|:||.
pombe   263 TACERAKRTLSSSAQASIEIDSLFEGIDFYTSITRARFEELCADLFRKTMEPVERVLRDSKVDKA 327

  Fly   328 QIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLV 392
            .:::|||||||||||:||.|:.|||:||....|||||||||||||||||:|:||.|.|.||:||:
pombe   328 SVNEIVLVGGSTRIPRVQKLVSDFFNGKEPCKSINPDEAVAYGAAVQAAVLTGDTSEKTQDLLLL 392

  Fly   393 DVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEGERAMTKDNNALGTF 457
            ||||||:||||||||||.||:||..||.|:::.||||:||||||.|||:|||||.|||.|.||.|
pombe   393 DVAPLSMGIETAGGVMTPLIKRNTTIPTKKSEIFSTYSDNQPGVLIQVFEGERARTKDCNLLGKF 457

  Fly   458 DLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEK 522
            :|||||||||||||||||||:||||||||||.|..|||.:.|||.|||||||:.||||||.||||
pombe   458 ELSGIPPAPRGVPQIEVTFDVDANGILNVSALEKGTGKTQKITITNDKGRLSKEEIDRMVAEAEK 522

  Fly   523 YADEDEKHRQRITSRNALESYVFNVKQAVEQAP-AGKLDEADKNSVLDKCNDTIRWLDSNTTAEK 586
            |..|||....||.::|.||||.::::.:::... ..|:|.:||.:|.....:||.||||||||.|
pombe   523 YKAEDEAESGRIQAKNHLESYAYSLRNSLDDPNLKDKVDASDKETVDKAVKETIEWLDSNTTAAK 587

  Fly   587 EEFDHKLEELTRHCSPIMTKMHQQGAGAGAGGPGANCGQQAGGF-----GGYSGPTVEEVD 642
            :||:.|.:||....:|||.|::|.| ||..|.|||..|...|..     ||.:||.|||||
pombe   588 DEFEAKQKELESVANPIMAKIYQAG-GAPGGMPGAAPGAAPGAAPGAAPGGDNGPEVEEVD 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	451/644 (70%)
Hsp70Aa	NP_731651.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	288/375 (77%)
ssa2	NP_588421.1	PTZ00009	4..647	CDD:240227	451/644 (70%)
ssa2	NP_588421.1	HSPA1-2_6-8-like_NBD	4..379	CDD:212675	288/375 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720