DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp70Aa and Hspa4l

DIOPT Version :9

Sequence 1:	NP_731651.1	Gene:	Hsp70Aa / 48581	FlyBaseID:	FBgn0013275	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_035150.3	Gene:	Hspa4l / 18415	MGIID:	107422	Length:	838	Species:	Mus musculus

Alignment Length:	704	Identity:	199/704 - (28%)
Similarity:	342/704 - (48%)	Gaps:	101/704 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVF 65
            |..:|||||.....:.|.:.|.:|.|||:..:|.||:.::.....|.||:.||:|:..|.|||:.
Mouse     1 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIH 65

  Fly    66 DAKRLIGRKYDDPKIAEDMKHWPFKVVS-DGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAE 129
            ..|:|.||.:|||.:..:....|:::.. ..|...:.|.|..|.:.||.|:::.|:|.|:|||:|
Mouse    66 GFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSTGVKVRYLEEERPFAIEQVTGMLLAKLKETSE 130

  Fly   130 AYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKN-----LKGE 189
            ..|.:.:.|.||::|::|.|::|::...|..:||||.||::||.||.|||||:.|.     .:..
Mouse   131 NALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPSLDEKP 195

  Fly   190 RNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSN 254
            |||:..|:|...:.||:...::|.| :|.:|..|.:|||.:||..||.:..||||.|||.:::.|
Mouse   196 RNVVFIDMGHSAYQVSVCAFNKGKL-KVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKEN 259

  Fly   255 PRALRRLRTAAERAKRTLS-SSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKA 318
            .|||.||....|:.|:.:| ::::..:.|:......|..:|::||:||:|||.|......|::..
Mouse   260 SRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKSV 324

  Fly   319 LNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQS 383
            ::.|.:.:..|:.|.:|||:||||.|:..:..||. |:::.::|.|||||.|.|:|.||||  .:
Mouse   325 MDQANLQREDINSIEIVGGATRIPAVKEQVTRFFL-KDISTTLNADEAVARGCALQCAILS--PA 386

  Fly   384 GKIQDVLLVDVAPLSLGIE-----TAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEG 443
            .|:::..:.|:.|.|:.:.     ..|....::..:|...|..:..||.   ..:|......|..
Mouse   387 FKVREFSITDLVPYSVTLRWKTSFEEGTGECEVFSKNHPAPFSKVITFH---KKEPFELEAFYTN 448

  Fly   444 ERAMTKDNNALGTFDLSGIPPAPRG-VPQIEVTFDLDANGILNVSAKEM---------------- 491
            ...:...:..:|.|.:..:.|...| ..:::|...::.:||.:|::..:
Mouse   449 LHEVPYPDPRIGNFTIQNVFPQSDGDSSKVKVKVRINIHGIFSVASASVIEKQNLEGDHNDAAME 513

  Fly   492 --------------------------------------STG-KAK----------NITIKNDK-- 505
                                                  .|| |||          |.|||..|
Mouse   514 TEAPKSEGKEDVDKMQVDQEEGGHQKCHAEHTPEEEIDHTGAKAKAPPSDKQDRINQTIKKGKIK 578

  Fly   506 -----------GRLSQAEIDRMVNEAEKYADEDEKHRQRITSRNALESYVFNVKQAVEQAPAGKL 559
                       .:|:|..::..:....|...:|:..::|..::||:|.||::.:..:.......:
Mouse   579 SIDLPIQSSLYRQLTQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDKLGTVYEKFI 643

  Fly   560 DEADKNSVLDKCNDTIRWL-DSNTTAEKEEFDHKLEELTRHCSPIMTKM--HQQ 610
            ...|.|.:.....||..|| :......|:.:..:|:||.::..||..|.  |::
Mouse   644 TPEDMNKLSAMLEDTENWLYEEGEDQPKQVYVDRLQELKKYGQPIQMKYVEHEE 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	198/703 (28%)
Hsp70Aa	NP_731651.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	143/382 (37%)
Hspa4l	NP_035150.3	HSPA4L_NBD	2..384	CDD:212688	143/383 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..566		5/59 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910