Protein Alignment Hsp70Aa and T14G8.3

DIOPT Version :10

• Sequence 1: NP_731651.1
• Gene: Hsp70Aa / 48581
• FlyBaseID: FBgn0013275
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_001024913.1
• Gene: T14G8.3 / 181422
• WormBaseID: WBGene00011771
• Length: 921
• Species: Caenorhabditis elegans
• Alignment Length: 733
• Identity: 191/733 - (26%)
• Similarity: 325/733 - (44%)
• Gaps: 157/733 - (21%)

  Fly     1 MPAIGIDLGTTYSCVGVYQHG-KVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTV 64
            :.|:.||||:.:..:|:.:.| .::|:.|.:..|.||:.::|.:.||...:.|....:.:|:::.
 Worm    26 LAAMSIDLGSQFIKIGLVKPGVPMDIVLNKESRRKTPNVISFKNDERFFAEAAAAMSSSHPQSSY 90

  Fly    65 FDAKRLIGRKYDDPKIAEDMKHWPFKVVS-DGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETA 128
            .....:|.||..|.......|.:||.... |..:..:...||.|  ::..|.:.:|:|...|:..
 Worm    91 NFLLSMIARKEGDDAFVTFQKTFPFTAFEFDEVRKTVVFPYKEE--KYNVETLLAMILWNAKKVT 153

  Fly   129 EAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKN---LKGER 190
            |||..:::.|.|||||.:.|.::|:|...|..|||||:|:::|:.:||||.||:.:.   .:...
 Worm   154 EAYADQTVKDVVITVPIFLNQAERRAIASAAEIAGLNLLQLLNDGSAAALNYGVFRRKEITEKPT 218

  Fly   191 NVLIFDLGGGTFDVSILTI----------DEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKR 245
            ::||:|:|......:|:..          |:...........|..|||.:..|||..||...|:.
 Worm   219 HMLIYDMGAVKTTATIVQYVLESTRKDGKDKQPTLRTVGVGFDKTLGGLEITNRLRDHLEKVFRD 283

  Fly   246 --KYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLF 308
              |..||:.:|.||:.:|...|||.|:.||::.:...::::|||.|:|..||:|...|::..||.
 Worm   284 TVKTSKDISTNARAIGKLHKEAERVKQVLSANKDTYAQVESLFEEQNFRAKVTREELEKMIEDLE 348

  Fly   309 RNTLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAV 373
            .....|:..|:..|::....|..:||:|..||:|||:.:|:.....|.::..:|.|||:|.||..
 Worm   349 PRIAAPILDAIGMAQISTNDIDLVVLMGAGTRVPKVKEILKTILKDKEISNFLNTDEAIAMGAVY 413

  Fly   374 QAAILSGDQSGK-----IQDVLLVDVAPLSLGIETAGGVM----TKLIERNCRIPCKQTKTFSTY 429
            |||.||  :|.|     :.:.:|..|. ::...:|..|.|    ..|...|..:| .:...||:|
 Worm   414 QAAHLS--KSFKVLPFNVHEKILYPVF-VNFLTKTEEGTMKPIRKSLFGENYPVP-NRVMHFSSY 474

  Fly   430 ADNQPGVSIQVYEGERAMTKDNNALGTFDLSGIPPA-----------PRGVPQIEVTFDLDANGI 483
            :|:   ..|.:.:.      |.|.|.|.::||:..|           .:||   :.||.:|.:||
 Worm   475 SDD---FKIDIQDA------DKNPLSTVEISGVKDAIEKEVTDENSVLKGV---KTTFSIDLSGI 527

  Fly   484 LNV-----------------------------------------------SAKEMSTG------- 494
            ::|                                               ..|:.:.|
 Worm   528 VSVEKASVVVEKVPTPEEKDKYEVDKKEFDEWEKEQEELKKKEKAEKKEKEEKKKTEGEEEKNED 592

  Fly   495 ----------------------------KAKNITI-------KNDKGRLSQAEI---DRMVNEAE 521
                                        |||.|.:       |.|...|::.|:   .:::.:.|
 Worm   593 AAGEEKTEEKTEEVEKPVVVKKTKPVEPKAKKINVALTIKETKTDNIDLNEEEVTAAKKVLGDFE 657

  Fly   522 KYADEDEKHRQRITSRNALESYVFNVKQAVEQAP--AGKLDEADKNSVLDKCNDTIRWLDSNTTA 584
            :  .|.||| .|..:.|.||..::::...:|...  |....|.:|.::|::......|.:.:.:.
 Worm   658 Q--KEKEKH-DREEAMNRLEGLLYDLAVRLEDGEEYAEYATEEEKKAILEEVAVLKLWFEDDVSL 719

  Fly   585 E--KEEFDH---KLEELT 597
            |  |||||.   ||||||
 Worm   720 ETKKEEFDEKRAKLEELT 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	191/732 (26%)
T14G8.3	NP_001024913.1	ASKHA_NBD_HSP70_HYOU1	27..416	CDD:466828	120/390 (31%)