Protein Alignment Hsp70Aa and Hyou1

DIOPT Version :10

• Sequence 1: NP_731651.1
• Gene: Hsp70Aa / 48581
• FlyBaseID: FBgn0013275
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_067370.3
• Gene: Hyou1 / 12282
• MGIID: 108030
• Length: 999
• Species: Mus musculus
• Alignment Length: 794
• Identity: 205/794 - (25%)
• Similarity: 341/794 - (42%)
• Gaps: 195/794 - (24%)

  Fly     1 MPAIGIDLGTTYSCVGVYQHG-KVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTV 64
            :..:.:|||:....|.:.:.| .:||:.|.:..|.||..|...::||.:||.|......||:.|:
Mouse    33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVTVTLKENERFLGDSAAGMAIKNPKATL 97

  Fly    65 FDAKRLIGRKYDDPKIAEDMKHWP-FKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETA 128
            ...:.|:|::.|:|.:|.....:| .:::.|..:..:..:...: .:|:|||:..|||...:..|
Mouse    98 RYFQHLLGKQADNPHVALYRSRFPEHELIVDPQRQTVRFQISPQ-LQFSPEEVLGMVLNYSRSLA 161

  Fly   129 EAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGL----DKNLKGE 189
            |.:..:.|.||||||||:||.::|:|...|..:|||.||::||:.||.||:||:    |.|...:
Mouse   162 EDFAEQPIKDAVITVPAFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINSTAQ 226

  Fly   190 RNVLIFDLGGGTFDVSILTID-----EGSL---FEVRSTAGDTHLGGEDFDNRLVTHLADEFKRK 246
             ||:.:|:|.|:...:|:|..     |..:   .::|....|..|||.:.:.||..|||..|..:
Mouse   227 -NVMFYDMGSGSTVCTIVTYQTVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLREHLAKLFNEQ 290

  Fly   247 YK----KDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADL 307
            .|    ||:|.||||:.:|...|.|.|..||::.:...:|:.|.:..||..||:|..||||||||
Mouse   291 RKGQKAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADL 355

  Fly   308 FRNTLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAA 372
            |.....||::||..|:|...||..::||||:||:||||.:|......:.|..:||.|||.|.||.
Mouse   356 FDRVPGPVQQALQSAEMSLDQIEQVILVGGATRVPKVQEVLLKAVGKEELGKNINADEAAAMGAV 420

  Fly   373 VQAAILSGDQSGKIQDVLLVD--VAPL----SLGIETAGGVMTKLIERNCRI--------PCKQT 423
            .|||.||  ::.|::..::.|  :.|:    :..:|...|:  :.::.|.|:        |.::.
Mouse   421 YQAAALS--KAFKVKPFVVRDAVIYPILVEFTREVEEEPGL--RSLKHNKRVLFSRMGPYPQRKV 481

  Fly   424 KTFSTYAD------NQPGVSIQVYEGERAMTKDNNALGTFDLSGIPPAPRGVPQ-----IEVTFD 477
            .||:.|:.      |...:.....|..|.....|  |.|..|.|:..:.:..|.     |:..|:
Mouse   482 ITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQN--LTTVKLKGVGESFKKYPDYESKGIKAHFN 544

  Fly   478 LDANGILNV--------------------------------------SAKEMST----------- 493
            ||.:|:|::                                      .|||..|
Mouse   545 LDESGVLSLDRVESVFETLVEDSPEEESTLTKLGNTISSLFGGGTSSDAKENGTDAVQEEEESPA 609

  Fly   494 ------------------------------------------------GKAKNITIKNDKGR--- 507
                                                            |........|:||:
Mouse   610 EGSKDEPAEQGELKEEAEPPAEETSQPPPSEPKGDAAREGEKPDEKESGDKPEAQKPNEKGQAGP 674

  Fly   508 ------------------------------------LSQAEIDRMVNEAEKYADEDEKHRQRITS 536
                                                |.:.|:.|.|.:.|:....|.:.::|..:
Mouse   675 EGAAPAPEEDKKPKPARKQKMVEEIGVELAVLDLPDLPEDELARSVQKLEELTLRDLEKQEREKA 739

  Fly   537 RNALESYVFNVKQAVEQAPAGKLD-EADKNSVLDKCNDTIRWLDSN----TTAEKEEFDHKLEEL 596
            .|:||:::|..:..:.|....::. |..:..:..|.:.|..||:..    ||...::   ||.||
Mouse   740 ANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSATSTWLEDEGFGATTVMLKD---KLAEL 801

  Fly   597 TRHCSPIMTKMHQQ 610
            .:.|..:..::.::
Mouse   802 RKLCQGLFFRVEER 815

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	205/793 (26%)
Hyou1	NP_067370.3	ASKHA_NBD_HSP70_HYOU1	34..424	CDD:466828	143/391 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	567..694		8/126 (6%)
		PHA03169	<586..>691	CDD:223003	8/104 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	909..999
		Prevents secretion from ER. /evidence=ECO:0000255	996..999