DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60B and CCT3

DIOPT Version :9

Sequence 1:	NP_524925.1	Gene:	Hsp60B / 48572	FlyBaseID:	FBgn0011244	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_012520.1	Gene:	CCT3 / 853438	SGDID:	S000003551	Length:	534	Species:	Saccharomyces cerevisiae

Alignment Length:	597	Identity:	124/597 - (20%)
Similarity:	227/597 - (38%)	Gaps:	142/597 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SKDVRFGSGVRAMMIRGVDILADAVAVTMGPKGRSVIVERPWTSPKITKDGFTVARSIALKDQHM 85
            |::...|...:...|.....:||.:...:|||....::..|.....:|.||..:.|.|.:    .
Yeast    11 SQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDV----A 71

  Fly    86 NLGAKLVQDVADNTNESAGDGTTTATVLA-RAIAKEGFNQITMGANPVEIRRGVMLAVDVVKDKL 149
            :..||.:.:::...:|..||||||..:|| ..:|:.....|....:||.|.:.:..|:....:.:
Yeast    72 HPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVI 136

  Fly   150 KEMSKAVETREEIQQVATLSANGDT-----------------------EIGRLI-GEATDKVGPR 190
            |::||.|:...:......:.|:..|                       ::|:.: ||      |.
Yeast   137 KQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGE------PN 195

  Fly   191 GTITVKDGKRLK-----DELN--IIQGLRFDNGYVSPFF---------------VNSSKG----- 228
            ..|.:|...|::     |.|:  :::|:..:...|.|..               :...||
Yeast   196 FEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTN 260

  Fly   229 ---SKVEFANALVMISLKKITGLSQIVKGLEQSLRQRRPLIIIAEDISGEALNALVLNKLRLGLQ 290
               .|.|..|.::.|..:::    |::  .||.|..|..|:|..:.:|..|.:.|    |:.|
Yeast   261 IEIEKEEDWNRILQIEEEQV----QLM--CEQILAVRPTLVITEKGVSDLAQHYL----LKGG-- 313

  Fly   291 VCAV-----KSPSYGHHRKELIGDISAATGATIFGDDINYSKMEEAKLEDLGQVGEAVISKDSTM 350
             |:|     ||.:         ..|:..|||||      .:::|:.|..|:|
Yeast   314 -CSVLRRVKKSDN---------NRIARVTGATI------VNRVEDLKESDVG------------- 349

  Fly   351 LLQGKPKTGLLEMRIQQIQDE---LAEKQIKPEQRDRLRQRLSALTKGVAVLHIGGGSEVEVNEK 412
                 ...||  .:::.|.||   ..:...:|:               ...:.:.|||:..:||.
Yeast   350 -----TNCGL--FKVEMIGDEYFSFLDNCKEPK---------------ACTIMLRGGSKDILNEI 392

  Fly   413 KDRVVDALNATR-AAIEEGIVPGGGTAFLRCIPYLQELKTESADLQK-GVDIVCNALRMPCQTIA 475
            ...:.||:...| ..:...:.||||...:.....|.|...:...:|: ....|.:|:....:|:.
Yeast   393 DRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLI 457

  Fly   476 QNAGVDGPMVV----AKVLNGSEDYGYDAMGDEYCRLVEKGIIDPTKVLRTAITDAAGVASLLST 536
            ||||.|...::    ||...|:...|.|....:...:|..||.:|..:.:.::..|...|.||..
Yeast   458 QNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLR 522

  Fly   537 TEVVITDSRNDD 548
            .:.:::..|..:
Yeast   523 VDDIVSGVRKQE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	124/597 (21%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	122/589 (21%)
CCT3	NP_012520.1	chap_CCT_gamma	4..533	CDD:274085	124/594 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810