Protein Alignment Hsp60B and HSP60

DIOPT Version :9

• Sequence 1: NP_524925.1
• Gene: Hsp60B / 48572
• FlyBaseID: FBgn0011244
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_013360.1
• Gene: HSP60 / 850963
• SGDID: S000004249
• Length: 572
• Species: Saccharomyces cerevisiae
• Alignment Length: 600
• Identity: 278/600 - (46%)
• Similarity: 401/600 - (66%)
• Gaps: 37/600 - (6%)

  Fly     1 MFRSCVPKAITSSR-CFARMYS--KDVRFGSGVRAMMIRGVDILADAVAVTMGPKGRSVIVERPW 62
            |.||.|.::..:.| ...|.||  |:::||...||.:::||:.||:|||.|:|||||:|::|:|:
Yeast     1 MLRSSVVRSRATLRPLLRRAYSSHKELKFGVEGRASLLKGVETLAEAVAATLGPKGRNVLIEQPF 65

  Fly    63 TSPKITKDGFTVARSIALKDQHMNLGAKLVQDVADNTNESAGDGTTTATVLARAIAKEGFNQITM 127
            ..|||||||.|||:||.|||:..|:||||:|:||..|||:||||||:||||.|||..|....:..
Yeast    66 GPPKITKDGVTVAKSIVLKDKFENMGAKLLQEVASKTNEAAGDGTTSATVLGRAIFTESVKNVAA 130

  Fly   128 GANPVEIRRGVMLAVDVVKDKLKEMSKAVETREEIQQVATLSANGDTEIGRLIGEATDKVGPRGT 192
            |.||:::|||..:||:.|.:.|....|.:.|.|||.||||:|||||:.:|:|:..|.:|||..|.
Yeast   131 GCNPMDLRRGSQVAVEKVIEFLSANKKEITTSEEIAQVATISANGDSHVGKLLASAMEKVGKEGV 195

  Fly   193 ITVKDGKRLKDELNIIQGLRFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLSQIVKGLEQ 257
            ||:::|:.|:|||.:.:|:|||.|::||:|:...|.|||||...|:::|.|||:.:..|:..||.
Yeast   196 ITIREGRTLEDELEVTEGMRFDRGFISPYFITDPKSSKVEFEKPLLLLSEKKISSIQDILPALEI 260

  Fly   258 SLRQRRPLIIIAEDISGEALNALVLNKLRLGLQVCAVKSPSYGHHRKELIGDISAATGATIFGDD 322
            |.:.||||:|||||:.||||.|.:|||||..::|||||:|.:|.:||..||||:..||.|:|.::
Yeast   261 SNQSRRPLLIIAEDVDGEALAACILNKLRGQVKVCAVKAPGFGDNRKNTIGDIAVLTGGTVFTEE 325

  Fly   323 INYSKMEEAKLEDLGQVGEAVISKDSTMLLQGK-PKTGLLEMRIQQIQDELAEKQIKPEQRDRLR 386
            ::. |.|:..:|:||......::|:.|::|.|. ||..:.| ||:||:..:........::::|:
Yeast   326 LDL-KPEQCTIENLGSCDSITVTKEDTVILNGSGPKEAIQE-RIEQIKGSIDITTTNSYEKEKLQ 388

  Fly   387 QRLSALTKGVAVLHIGGGSEVEVNEKKDRVVDALNATRAAIEEGIVPGGGTAFLRCIPYLQELKT 451
            :||:.|:.||||:.:||.|||||.|||||..|||||||||:||||:||||||.::....|.|:..
Yeast   389 ERLAKLSGGVAVIRVGGASEVEVGEKKDRYDDALNATRAAVEEGILPGGGTALVKASRVLDEVVV 453

  Fly   452 ESADLQKGVDIVCNALRMPCQTIAQNAGVDGPMVVAKVLNG-SEDY--GYDAMGDEYCRLVEKGI 513
            ::.|.:.||||:..|:..|.:.|.:|||.:|.:::.|:::. .:|:  ||||...||..::..||
Yeast   454 DNFDQKLGVDIIRKAITRPAKQIIENAGEEGSVIIGKLIDEYGDDFAKGYDASKSEYTDMLATGI 518

  Fly   514 IDPTKVLRTAITDAAGVASLLSTTEVVITDSRNDDLLSKLSGAGGGMDDGLDMNMGGLEELAALS 578
            |||.||:|:.:.||:||||||:||||.|.|:                           .|..|.:
Yeast   519 IDPFKVVRSGLVDASGVASLLATTEVAIVDA---------------------------PEPPAAA 556

  Fly   579 GLGGM-GGMGGMGGM 592
            |.||| |||.||.||
Yeast   557 GAGGMPGGMPGMPGM 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	261/555 (47%)
		GroEL	22..543	CDD:239460	256/524 (49%)
HSP60	NP_013360.1	GroEL	25..548	CDD:239460	256/524 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343954
Domainoid	1	1.000	582	1.000	Domainoid score	I30
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	626	1.000	Inparanoid score	I120
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61846
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	1	1.000	-	-		otm46722
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1504
TreeFam	1	0.960	-	-
	12	11.760