DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60B and CPN60B

DIOPT Version :9

Sequence 1:	NP_524925.1	Gene:	Hsp60B / 48572	FlyBaseID:	FBgn0011244	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001320637.1	Gene:	CPN60B / 841996	AraportID:	AT1G55490	Length:	600	Species:	Arabidopsis thaliana

Alignment Length:	568	Identity:	229/568 - (40%)
Similarity:	352/568 - (61%)	Gaps:	19/568 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RSCVPKAITSSR---CFAR--MYSKDVRFGSGVRAMMIRGVDILADAVAVTMGPKGRSVIVERPW 62
            :|..|:...||.   |.|:  .::||   |:.:|.:. .||:.|||.|.||:|||||:|::|..:
plant    39 QSVCPRPRRSSSAIVCAAKELHFNKD---GTTIRRLQ-AGVNKLADLVGVTLGPKGRNVVLESKY 99

  Fly    63 TSPKITKDGFTVARSIALKDQHMNLGAKLVQDVADNTNESAGDGTTTATVLARAIAKEGFNQITM 127
            .||:|..||.||||.:.|:|...|:|||||:..|..||:.|||||||:.|||:....||...:..
plant   100 GSPRIVNDGVTVAREVELEDPVENIGAKLVRQAAAKTNDLAGDGTTTSVVLAQGFIAEGVKVVAA 164

  Fly   128 GANPVEIRRGVMLAVDVVKDKLKEMSKAVETREEIQQVATLSANGDTEIGRLIGEATDKVGPRGT 192
            |||||.|.||:......:..:||:|||.||. .|:..||.:||..:.|||.:|.||..|||.:|.
plant   165 GANPVLITRGIEKTAKALVTELKKMSKEVED-SELADVAAVSAGNNDEIGNMIAEAMSKVGRKGV 228

  Fly   193 ITVKDGKRLKDELNIIQGLRFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLSQIVKGLEQ 257
            :|:::||..::.|.:::|::||.||:||:||..|:...|||.|..:::..||||....:|..||.
plant   229 VTLEEGKSAENNLYVVEGMQFDRGYISPYFVTDSEKMSVEFDNCKLLLVDKKITNARDLVGVLED 293

  Fly   258 SLRQRRPLIIIAEDISGEALNALVLNKLRLGLQVCAVKSPSYGHHRKELIGDISAATGATIFGDD 322
            ::|...|::||||||..|||..||:||||..|::.|:::|.:|..:.:.:.||:..||||:..::
plant   294 AIRGGYPILIIAEDIEQEALATLVVNKLRGTLKIAALRAPGFGERKSQYLDDIAILTGATVIREE 358

  Fly   323 INYSKMEEAKLEDLGQVGEAVISKDSTMLLQGKPKTGLLEMRIQQIQDELAEKQIKPEQRDRLRQ 387
            :..| :::|..|.||...:.|::|:::.::........::.|:.||:: |.|:..:..::::|.:
plant   359 VGLS-LDKAGKEVLGNASKVVLTKETSTIVGDGSTQDAVKKRVTQIKN-LIEQAEQDYEKEKLNE 421

  Fly   388 RLSALTKGVAVLHIGGGSEVEVNEKKDRVVDALNATRAAIEEGIVPGGGTAFLRCIPYLQELK-T 451
            |::.|:.||||:.:|..:|.|:.|||.||.||||||:||:|||||.|||...||....:..:| |
plant   422 RIAKLSGGVAVIQVGAQTETELKEKKLRVEDALNATKAAVEEGIVVGGGCTLLRLASKVDAIKAT 486

  Fly   452 ESADLQK-GVDIVCNALRMPCQTIAQNAGVDGPMVVAKVL-NGSEDYGYDAMGDEYCRLVEKGII 514
            ...|.:| |.|||..||..|.:.||:||||:|.:|..||| |.:..:||:|...:|..|:..|||
plant   487 LDNDEEKVGADIVKRALSYPLKLIAKNAGVNGSVVSEKVLSNDNVKFGYNAATGKYEDLMAAGII 551

  Fly   515 DPTKVLRTAITDAAGVASLLSTTEVVITDSRNDDLLSKLSGAGGGMDD 562
            |||||:|..:..||.||.....::.|:.:.:..:.:.    .|..||:
plant   552 DPTKVVRCCLEHAASVAKTFLMSDCVVVEIKEPEPVP----VGNPMDN 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	224/556 (40%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	220/523 (42%)
CPN60B	NP_001320637.1	PLN03167	1..600	CDD:215611	229/568 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D415781at2759
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.780