Protein Alignment Hsp60B and MKKS

DIOPT Version :9

• Sequence 1: NP_524925.1
• Gene: Hsp60B / 48572
• FlyBaseID: FBgn0011244
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_061336.1
• Gene: MKKS / 8195
• HGNCID: 7108
• Length: 570
• Species: Homo sapiens
• Alignment Length: 659
• Identity: 119/659 - (18%)
• Similarity: 188/659 - (28%)
• Gaps: 277/659 - (42%)

  Fly    38 VDILADAVAVTMGPKGRSVIVERPWTSPKITKDGF-----TVARSIALKDQ----HMNLGAKLVQ 93
            :.:|...|....||.||.          |...:||     |.::|.||...    |..|  |::.
Human    26 LSVLKRIVTSCYGPSGRL----------KQLHNGFGGYVCTTSQSSALLSHLLVTHPIL--KILT 78

  Fly    94 DVADNTNESAGD-GTTTATVLARAIAKEGFNQITMGANPVEIRR------------------GVM 139
            ....|...|..| |..||.:....|.    |...:|..|..:.|                  |..
Human    79 ASIQNHVSSFSDCGLFTAILCCNLIE----NVQRLGLTPTTVIRLNKHLLSLCISYLKSETCGCR 139

  Fly   140 LAVD---------VVKDKLKEMSKAVETREEIQQVATL-----------SANGDTEIGRLIGEAT 184
            :.||         :|:..|......:.||:|.:.|:.|           :|.|...:|:.:
Human   140 IPVDFSSTQILLCLVRSILTSKPACMLTRKETEHVSALILRAFLLTIPENAEGHIILGKSL---- 200

  Fly   185 DKVGPRGTITVKDGKRLKDELNIIQGLRFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLS 249
                    |....|:|:.|. .::.|:..:.             |:|:.   :.::.:||.|.|
Human   201 --------IVPLKGQRVIDS-TVLPGILIEM-------------SEVQL---MRLLPIKKSTAL- 239

  Fly   250 QIVKGLEQSLRQRRPLIIIAEDISGEALNALVLNKLRLGLQVCAVKSPSYGHHRKELIGDISAAT 314
                                              |:.|   .|..           |.||.|...
Human   240 ----------------------------------KVAL---FCTT-----------LSGDTSDTG 256

  Fly   315 GATIFGDDINYS-KMEEAKLEDLGQVGEAVISKDSTMLLQGKPKTGLLEMRIQQIQDELAEKQIK 378
            ..|:.   ::|. .:|.|.|:.|..:|..:||....::                    |.:|.|.
Human   257 EGTVV---VSYGVSLENAVLDQLLNLGRQLISDHVDLV--------------------LCQKVIH 298

  Fly   379 PEQRDRLRQR------------LSALTKGVAVLHIGG---------GSEVEV------------- 409
            |..:..|...            :..|||......||.         ||..:|
Human   299 PSLKQFLNMHRIIAIDRIGVTLMEPLTKMTGTQPIGSLGSICPNSYGSVKDVCTAKFGSKHFFHL 363

  Fly   410 --NE----------KKDRVVDALNAT-RAAI--------EEGIVPGGGTAFLRCIPYLQE----- 448
              ||          :.|...|.|..| :.|:        |...:.|||........|::.
Human   364 IPNEATICSLLLCNRNDTAWDELKLTCQTALHVLQLTLKEPWALLGGGCTETHLAAYIRHKTHND 428

  Fly   449 ----LKTE---SADLQKGVDIVCNALRMPCQTIAQNAG---------------VDGPMVV----- 486
                ||.:   ..:||...:..|:||.....::..:.|               .|.|.|.
Human   429 PESILKDDECTQTELQLIAEAFCSALESVVGSLEHDGGEILTDMKYGHLWSVQADSPCVANWPDL 493

  Fly   487 -----AKVLNGSEDYGYDAMGDEYCRLVEKGIIDPTKVLRTAITDAAGVASLLSTTEVVITDSRN 546
                 ..:.|..|:..:     .:.|...:..: |...|.   .:|.|.||.|:.
Human   494 LSQCGCGLYNSQEELNW-----SFLRSTRRPFV-PQSCLP---HEAVGSASNLTL---------- 539

  Fly   547 DDLLSKLSG 555
            |.|.:||||
Human   540 DCLTAKLSG 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	119/659 (18%)
		GroEL	22..543	CDD:239460	113/645 (18%)
MKKS	NP_061336.1	Cpn60_TCP1	29..569	CDD:278544	119/656 (18%)
		chaperonin_like	32..476	CDD:295468	99/560 (18%)
		Substrate-binding apical domain	198..370		42/272 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900