DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60B and Bbs10

DIOPT Version :9

Sequence 1:	NP_524925.1	Gene:	Hsp60B / 48572	FlyBaseID:	FBgn0011244	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_082190.1	Gene:	Bbs10 / 71769	MGIID:	1919019	Length:	713	Species:	Mus musculus

Alignment Length:	736	Identity:	131/736 - (17%)
Similarity:	234/736 - (31%)	Gaps:	255/736 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 IRGVDILADAVAVTMGPKGRSVIVERPWTSPKITKDGFTVARSIALKDQHMNLGAKLVQDVADNT 99
            :|..::|.......:||:|..|:..:|.....:::||..:..::.|:..   |...:|..|:.:.
Mouse    11 LRVAEVLESIANRCVGPEGGQVLCTKPTGEVLLSRDGGCLLEALHLEHP---LARMIVACVSSHL 72

  Fly   100 NESAGDGTTTATVL-------ARAIAKEG---------------------FNQITMGANPVEIRR 136
            .:: |||..|..:.       ..||.::|                     :..|:......:.:.
Mouse    73 KKT-GDGAKTFIIFLCHLLRGLHAIGEKGKDSFTSENIQSHERHWKNCCQWKSISQALQTFQTQT 136

  Fly   137 -GVMLAVDVVKDKLKEMSKAVETRE----------EIQQVATLSANGDTEIGRLIGEATDK---- 186
             |.::...:.:..|...|.:.|.|:          |......:..|....|.:|:.:...|
Mouse   137 LGCIVDRSLSRHYLSVFSSSTEGRKLCRHSLELLLEAYFCGRVGRNNHRFISQLMCDYVFKCMAC 201

  Fly   187 ------------------VGPRGTITVKDGKRLKDELNIIQGLRFDNGY---------------- 217
                              ||..| :.|.|.:       ||.||.....:
Mouse   202 ESGVEVFELLDHCFAELNVGVTG-LPVSDSR-------IIDGLVLPRDFSMYCPADGDIRMVIVT 258

  Fly   218 --VSPFFVNSSKG------SKVEFANALVMISLKKITGLS----QIVKGLEQSLRQ--------R 262
              :.|.|  ||.|      |:.:|..:...|:.:..|.::    |.||.|..|::|        |
Mouse   259 EILQPQF--SSAGSEFVLNSETQFQASQCWITDRTKTVMNHLRGQNVKLLLTSVKQPDLVIYCAR 321

  Fly   263 RPLIIIAEDISGEALNALVLNKLRLGLQVCA-----------------------VKSPSYGH--- 301
            ...|.:.|.:|.|.::   |.:...||..|.                       ::|..|.|
Mouse   322 LNSISVVECLSAEEVS---LVQRITGLSPCVLPEVASQCEISDSTLVKFCKPLILRSKRYVHLGL 383

  Fly   302 --------HRKELIGDI--------SAATGA-----TIFGD-DINYSKMEEAKLEDLGQVGEAVI 344
                    |...|.|.:        .|..||     .:|.| |:||.      ::...|...:.:
Mouse   384 ISTCAFIPHSMVLCGPVLGLVEQHERAFHGAFKMLRQLFTDLDLNYI------IQTKQQCNPSPL 442

  Fly   345 SKDSTMLLQGKPKTGLLEMRIQQIQDELAEKQIKPEQRDRLRQRLSALTKGVAVLHIG-GGSEVE 408
            :.|::......|:|       .:.||.:|:.:.|.|.:..|.            ::.| |.|:.|
Mouse   443 AYDNSRERNHSPET-------DKYQDIVAKSKNKLETQTHLE------------VYSGLGASDTE 488

  Fly   409 VNEKKDRVVDALNATRAAIEEGIVPGGGTAFLRCIPYLQELKTESADL-------------QKGV 460
            :...|        ...|..:..|.|......|:|:|..:....::.||             ..|.
Mouse   489 LRAGK--------PWSAHKKTPIAPSQTDEMLKCLPPERSGIIDNCDLSIENHSTGNPTAEDTGT 545

  Fly   461 DIVCNALRMPCQTIAQNAGVDGPM-VVAKVLNGSEDYGYDA----------MGDEYCRLVEKGII 514
            :|....|:     ::.|||....: |:.|.|:.....||.:          :|..:..|:...::
Mouse   546 EISFEHLQ-----VSDNAGKGYTLPVMRKSLDTCTCQGYCSSTVPAGCVLPVGGSFEILMSYYLL 605

  Fly   515 DPTK--------VLRTAITDAAGVASLLSTTEVVITDSRNDDLLSKLSGAGGGMDDGLDMNMGGL 571
            ...|        |:...|.||     ||...:::....:             |.|....:.|..|
Mouse   606 SYAKQCRQSDETVISMLIADA-----LLGIPKILYKPKK-------------GKDSFPHIYMRSL 652

  Fly   572 EELAA----LSGLGGMGGMGG 588
            ..|.|    :||..|...:.|
Mouse   653 HALQASQPMVSGQSGFESVAG 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	121/700 (17%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	121/685 (18%)
Bbs10	NP_082190.1	chaperonin_like	7..>111	CDD:295468	20/103 (19%)
		Cpn60_TCP1	13..>424	CDD:278544	73/427 (17%)
		CNH	111..>209	CDD:295303	11/97 (11%)
		chaperonin_like	<587..695	CDD:295468	19/105 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900