Protein Alignment Hsp60B and TCP1

DIOPT Version :9

• Sequence 1: NP_524925.1
• Gene: Hsp60B / 48572
• FlyBaseID: FBgn0011244
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_110379.2
• Gene: TCP1 / 6950
• HGNCID: 11655
• Length: 556
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 130/604 - (21%)
• Similarity: 226/604 - (37%)
• Gaps: 166/604 - (27%)

  Fly    27 GSGVRAMMIRGVDILADAVAVTMGPKGRSVIVERPWTSPKITKDGFTVARSIALKDQHMNLGAKL 91
            |..:|:..:.....:|:.|..::||.|...::........||.||.|:.:  .|:.:|.  .||:
Human    14 GETIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILK--LLEVEHP--AAKV 74

  Fly    92 VQDVADNTNESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRRGVMLAVDVVKDKLKEMSKAV 156
            :.::||..::..|||||:..::|..:.|.....:....:|..:..|..||
Human    75 LCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLA--------------- 124

  Fly   157 ETREEIQQV-ATLSANGDTEIGR--LIGEATDKVGPRGTITVKDGKRLKDELNIIQGLRFDNGYV 218
             .:|.::.: ..|..|.| |:||  ||..|...:..:                 |.|:..|
Human   125 -CKEAVRYINENLIVNTD-ELGRDCLINAAKTSMSSK-----------------IIGINGD---- 166

  Fly   219 SPFFVNSSKGSKVEFANALVMISLKKITGLSQ-------IVKGLEQSLRQRRPLIIIAEDISGEA 276
              ||.|.       ..:|::.|....|.|..:       |:|...:|  |...::     |||.|
Human   167 --FFANM-------VVDAVLAIKYTDIRGQPRYPVNSVNILKAHGRS--QMESML-----ISGYA 215

  Fly   277 LNALV----------------------LNKLRLGLQVCAVKSPSYGHHRKELIGDIS-------A 312
            ||.:|                      ..|::||:|| .:..|......::...||:       .
Human   216 LNCVVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQV-VITDPEKLDQIRQRESDITKERIQKIL 279

  Fly   313 ATGATIF----G-DDINYSKMEEAKL--------EDLGQVGEAVISKDSTML-----LQGKP--K 357
            ||||.:.    | ||:......||..        .||.::.:|   ..:|:|     |:|:.  :
Human   280 ATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKA---SGATILSTLANLEGEETFE 341

  Fly   358 TGLLEMRIQQIQDELAEKQIKPEQRDRLRQRLSALTKGVAVLHIGGGSEVEVNEKKDRVVDALNA 422
            ..:|....:.:|:.:.:.::...:..:.|...|.:.:        |.::...:|.:..:.|||..
Human   342 AAMLGQAEEVVQERICDDELILIKNTKARTSASIILR--------GANDFMCDEMERSLHDALCV 398

  Fly   423 TRAAIE-EGIVPGGGTAFLRCIPYLQELKTES--------ADLQKGVDIVCNALRMPCQTIAQNA 478
            .:..:| :.:|||||........||:...|..        |:..:.:.::.|       |:|.||
Human   399 VKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPN-------TLAVNA 456

  Fly   479 GVDGPMVVAKV--------LNGSED----YGYDAMGDEYCRLVEKGIIDPTKVLRTAITDAAGVA 531
            ..|...:|||:        :|....    .|.|....:.....:.|:.:||.|         .|.
Human   457 AQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLSNGKPRDNKQAGVFEPTIV---------KVK 512

  Fly   532 SLLSTTEVVITDSRNDDLL 550
            ||...||..||..|.|||:
Human   513 SLKFATEAAITILRIDDLI 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	130/604 (22%)
		GroEL	22..543	CDD:239460	125/595 (21%)
TCP1	NP_110379.2	TCP1_alpha	9..535	CDD:239451	130/604 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810