DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60B and Hspd1

DIOPT Version :9

Sequence 1:	NP_524925.1	Gene:	Hsp60B / 48572	FlyBaseID:	FBgn0011244	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_071565.2	Gene:	Hspd1 / 63868	RGDID:	621314	Length:	573	Species:	Rattus norvegicus

Alignment Length:	593	Identity:	331/593 - (55%)
Similarity:	432/593 - (72%)	Gaps:	40/593 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SRCFA----RMYSKDVRFGSGVRAMMIRGVDILADAVAVTMGPKGRSVIVERPWTSPKITKDGFT 73
            ||..|    |.|:|||:||:..||:|::|||:||||||||||||||:||:|:.|.|||:||||.|
  Rat    15 SRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVT 79

  Fly    74 VARSIALKDQHMNLGAKLVQDVADNTNESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRRGV 138
            ||:||.|||::.|:|||||||||:||||.|||||||||||||:||||||.:|:.|||||||||||
  Rat    80 VAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGV 144

  Fly   139 MLAVDVVKDKLKEMSKAVETREEIQQVATLSANGDTEIGRLIGEATDKVGPRGTITVKDGKRLKD 203
            |||||.|..:||:.||.|.|.|||.||||:|||||.:||.:|.:|..|||.:|.|||||||.|.|
  Rat   145 MLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLND 209

  Fly   204 ELNIIQGLRFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLSQIVKGLEQSLRQRRPLIII 268
            ||.||:|::||.||:||:|:|:|||.|.||.:|.|::|.|||:.:..||..||.:...|:||:||
  Rat   210 ELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVII 274

  Fly   269 AEDISGEALNALVLNKLRLGLQVCAVKSPSYGHHRKELIGDISAATGATIFGDDINYSKMEEAKL 333
            |||:.||||:.||||:|::||||.|||:|.:|.:||..:.|::.|||..:||::.....:|:.:.
  Rat   275 AEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQA 339

  Fly   334 EDLGQVGEAVISKDSTMLLQGKPKTGLLEMRIQQIQDELAEKQIKPEQRDRLRQRLSALTKGVAV 398
            .|||:|||.:::||..|||:||.....:|.|||:|.::| :......::::|.:||:.|:.||||
  Rat   340 HDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQL-DITTSEYEKEKLNERLAKLSDGVAV 403

  Fly   399 LHIGGGSEVEVNEKKDRVVDALNATRAAIEEGIVPGGGTAFLRCIPYLQELKTESADLQKGVDIV 463
            |.:||.|:||||||||||.|||||||||:|||||.|||.|.|||||.|..||..:.|.:.|::|:
  Rat   404 LKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEII 468

  Fly   464 CNALRMPCQTIAQNAGVDGPMVVAKVLNGSEDYGYDAMGDEYCRLVEKGIIDPTKVLRTAITDAA 528
            ..||::|..|||:||||:|.::|.|:|..|.:.|||||..::..:|||||||||||:|||:.|||
  Rat   469 KRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAA 533

  Fly   529 GVASLLSTTEVVITDSRNDDLLSKLSGAGGGMDDGLDMNMGGLEELAALSGLGGMGGMGGMGGMG 593
            ||||||:|.|.|:|:...::           .|.                      |||.|||||
  Rat   534 GVASLLTTAEAVVTEIPKEE-----------KDP----------------------GMGAMGGMG 565

  Fly   594 GMGGMGGG 601
              ||||||
  Rat   566 --GGMGGG 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	316/548 (58%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	310/520 (60%)
Hspd1	NP_071565.2	GroEL	28..548	CDD:239460	310/520 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341492
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61846
OrthoDB	1	1.010	-	-		D183447at33208
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1504
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760