DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60B and cct2

DIOPT Version :9

Sequence 1:	NP_524925.1	Gene:	Hsp60B / 48572	FlyBaseID:	FBgn0011244	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001006757.1	Gene:	cct2 / 448434	XenbaseID:	XB-GENE-1006535	Length:	535	Species:	Xenopus tropicalis

Alignment Length:	561	Identity:	126/561 - (22%)
Similarity:	208/561 - (37%)	Gaps:	126/561 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GVDILADAVAVTMGPKGRSVIVERPW--TSPKITKDGFTVARSIALKDQHMNLGAKLVQDVADNT 99
            |...:.|.|..|:||||...|:....  ::..:|.||.|:.::|.:.    |..|:::.|::...
Frog    31 GAIAIGDLVKSTLGPKGMDKILLSSGRDSTVTVTNDGATILKAIGID----NPAAQVLVDMSKVQ 91

  Fly   100 NESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRRGVMLAVDVVKDKLKEMSKAVETREE--- 161
            ::..|||||:.||||..:.:|....:....:|..|..|...|..|.::.|...|......||
Frog    92 DDEVGDGTTSVTVLAAELLREAEVLVARKIHPQTIISGWRQATQVAREALLNASVDHGNDEEKFR 156

  Fly   162 ---------------------------IQQVATLSANGDTEIGRLIGEATDKVGPRGTIT---VK 196
                                       ::.|..|..:|:.|...:|    .|:|  |::|   :.
Frog   157 CDLLNIARTTLSSKLLTHHKDHFSKLAVEAVLRLKGSGNLEAIHVI----KKLG--GSLTESYLD 215

  Fly   197 DGKRLKDELNIIQGLRFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITG----LSQIVKGLEQ 257
            :|..|..::.:.|..|.:|             :|:..||..:.....||.|    :....|..|.
Frog   216 EGFLLDKKIGVNQPKRIEN-------------AKILIANTGMDTDKIKIFGSRVRVDSTAKVAEI 267

  Fly   258 SLRQRRPLIIIAEDISGEALNALVLNKLRLGLQ--------VCAVKSPSY-GHHRKELIGDISAA 313
            .|.::..:....|.|....:|..:..:|.....        |.|::...: |..|..|:
Frog   268 ELAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFATAGVMAIEHADFAGVERLALV------ 326

  Fly   314 TGATIFGDDINYSKMEEAKLEDLGQVGEAVISKDSTM----LLQGKPKTGLLEMRIQQIQDELAE 374
            ||..|..   .:...|..||.....:.|.:|.:|..:    :..|:..|.:|....|||.|| ||
Frog   327 TGGEIAS---TFDHPELVKLGTCKLIEEVMIGEDKLIHFSGVAMGEACTIVLRGATQQILDE-AE 387

  Fly   375 KQIKPEQRDRLRQRLSALTKGVAVLHIGGGSEVEVNEKKDRVVDALNATRAAIEEGIVPGGGTAF 439
            :.:    .|.|.. |:...|....::.||.||         ::.|...|..||.   .||
Frog   388 RSL----HDALCV-LAQTVKDTRTVYGGGCSE---------MLMAHAVTELAIR---TPG----- 430

  Fly   440 LRCIPYLQELKTESADLQKGVDIVCNALRMPCQTIAQNAGVDGPMVVAKV----LNGSEDYGYDA 500
                       .||..::.    ...||||....||.|||.|...:|:::    ..|...||.|.
Frog   431 -----------KESVAMES----FAKALRMLPTIIADNAGYDSADLVSQLRAAHSEGKSTYGLDM 480

  Fly   501 MGDEYCRLVEKGIIDPTKVLRTAITDAAGVASLLSTTEVVI 541
            .......:.|.||.:..:|.|..:..|:..|.::...:.:|
Frog   481 KNGTIGEMGELGITESFQVKRQVLLSASEAAEVILRVDNII 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	126/561 (22%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	126/561 (22%)
cct2	NP_001006757.1	TCP1_beta	11..527	CDD:239452	126/561 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910