DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60B and Hsp60C

DIOPT Version :9

Sequence 1:	NP_524925.1	Gene:	Hsp60B / 48572	FlyBaseID:	FBgn0011244	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster

Alignment Length:	583	Identity:	345/583 - (59%)
Similarity:	443/583 - (75%)	Gaps:	31/583 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FARMYSKDVRFGSGVRAMMIRGVDILADAVAVTMGPKGRSVIVERPWTSPKITKDGFTVARSIAL 80
            :||.|:||||||..|||||::|||:||||||||||||||:||:|:.|.||||||||.|||:||||
  Fly    22 WARNYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIAL 86

  Fly    81 KDQHMNLGAKLVQDVADNTNESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRRGVMLAVDVV 145
            ||:..|:|||||||||:||||.||||||||||||||||||||.:|:.||:|||||||||||::.|
  Fly    87 KDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISRGASPVEIRRGVMLAIETV 151

  Fly   146 KDKLKEMSKAVETREEIQQVATLSANGDTEIGRLIGEATDKVGPRGTITVKDGKRLKDELNIIQG 210
            ||.|:.:|:.|.|.|||.||||:|||||..:|.||.||..|||..|.|||||||.|.|||.:|:|
  Fly   152 KDNLRRLSRPVNTPEEICQVATISANGDKSVGNLISEAIKKVGRDGVITVKDGKTLCDELEVIEG 216

  Fly   211 LRFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLSQIVKGLEQSLRQRRPLIIIAEDISGE 275
            ::||.||:||:|:|:|||:||||.:||::...|||.....||..||.:..||:||:|||||:..|
  Fly   217 MKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSAPSIVPALELANAQRKPLVIIAEDLEAE 281

  Fly   276 ALNALVLNKLRLGLQVCAVKSPSYGHHRKELIGDISAATGATIFGDDINYSKMEEAKLEDLGQVG 340
            ||:.||:|:|::||||||||:|.:|.:|||.:.|::.|||..:|||:.|..::|:.|:.|.|:||
  Fly   282 ALSTLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVATGGIVFGDEANMVRLEDIKMSDFGRVG 346

  Fly   341 EAVISKDSTMLLQGKPKTGLLEMRIQQIQDELAEKQIKPEQRDRLRQRLSALTKGVAVLHIGGGS 405
            |.|:|||.||||:||.:...:|.|::.:::.:.|.....| ::::::||:.|:.|||:|.:||.|
  Fly   347 EVVVSKDDTMLLKGKGQKAEVEKRVEGLREAIKESTSSYE-KEKMQERLARLSSGVALLRVGGSS 410

  Fly   406 EVEVNEKKDRVVDALNATRAAIEEGIVPGGGTAFLRCIPYLQELKTESADLQKGVDIVCNALRMP 470
            :|||:||||||:|||||||||:|||||||||||.||||..|.:||..:.|...|::|:..|||||
  Fly   411 DVEVSEKKDRVIDALNATRAAVEEGIVPGGGTALLRCIQKLNDLKGANEDQNMGIEIIRRALRMP 475

  Fly   471 CQTIAQNAGVDGPMVVAKV--LNGSEDYGYDAMGDEYCRLVEKGIIDPTKVLRTAITDAAGVASL 533
            |.|||:||||||.||||||  |:|  ||||||:..||..::|:||||||||:||||:||||||||
  Fly   476 CLTIAKNAGVDGAMVVAKVEILDG--DYGYDALKGEYGNMIERGIIDPTKVVRTAISDAAGVASL 538

  Fly   534 LSTTEVVITDSRNDDLLSKLSGAGGGMDDGLDMNMGGLEELAALSGLGGMGGMGGMGGMGGMG 596
            |:|.|.|:|:.                         .|||.||.....|:|.:||| ||||||
  Fly   539 LTTAEAVVTEL-------------------------PLEEAAAAGAAAGLGALGGM-GMGGMG 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	329/543 (61%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	325/522 (62%)
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	330/557 (59%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	325/522 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449863
Domainoid	1	1.000	580	1.000	Domainoid score	I40
eggNOG	1	0.900	-	-		E1_COG0459
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	652	1.000	Inparanoid score	I167
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D183447at33208
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	1	1.000	-	-		otm51386
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	P	PTHR45633
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1504
	11	10.800