DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60B and CCT6

DIOPT Version :9

Sequence 1:	NP_524925.1	Gene:	Hsp60B / 48572	FlyBaseID:	FBgn0011244	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_573066.1	Gene:	CCT6 / 32518	FlyBaseID:	FBgn0027329	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	575	Identity:	116/575 - (20%)
Similarity:	211/575 - (36%)	Gaps:	137/575 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 AMMIRGVDILADAVAVTMGPKGRSVIVERPWTSPKITKDGFTVARSIALKDQHMNLGAKLVQDVA 96
            |:.|.....|.|.:...:||||...::.......||||||..:...:.:  ||..  |.::...:
  Fly    21 AINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLHEMQI--QHPT--ASMIARAS 81

  Fly    97 DNTNESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRRGVMLAVDVVKDKLKEMSKAVE-TRE 160
            ...::|.||||||..:|...:.|:....::.|.:|..:..|...|.|...:.|.::...|| .::
  Fly    82 TAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKARDKALEVLDQVKVPVEINKK 146

  Fly   161 EIQQVATLSANGDTEIGRLIGEATDKVGPRGTITVKDGKRLK-----------------DELNII 208
            .:.:||..|..  |::...:.:....|.....:|:....:.|                 .:..::
  Fly   147 NLVEVANTSLK--TKVHPALADLLTDVCVNAVLTIASADKTKPVDLHMVELMEMQHKSDTDTQLV 209

  Fly   209 QGLRFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLSQIVKGLEQSLRQRRPLIIIAEDIS 273
            :||..|:|...|......:.:.:..||  |.:..:|    :::..|......:.|...:.||
  Fly   210 RGLVMDHGARHPDMPKRLENAYILTAN--VSLEYEK----AEVNSGFFYKTAEEREAFVRAE--- 265

  Fly   274 GEALNALVLNKLRLGLQVCAVKSPSY------------------------GHHRKELIGDISAAT 314
            .|.::..|...:.|...||.....::                        ...::..:..:|.|.
  Fly   266 REFIDQRVKKVIELKRSVCDGTDKTFVLINQKGIDPISLDALAKEGILALRRAKRRNMERLSLAC 330

  Fly   315 GATIFGDDINYSKMEEAKLEDLGQVGEAVISKDS-------------TMLLQGKPKTGLLEMRIQ 366
            |.|...   ::..::|..|...|.|.|.|:.::.             |:|::|..|     ..|.
  Fly   331 GGTAMN---SFDDLQEEHLGYAGVVYEHVLGENKYTFVEDCKNPLSVTILIKGPNK-----HTIT 387

  Fly   367 QIQDELAEKQIKPEQRDRLRQRLSALTKGVAVLHIGGGSEVEVNEKKDRVVDALNATRAAIEEGI 431
            ||:|.:         ||.||                                |:|.|.|  ::.:
  Fly   388 QIKDAI---------RDGLR--------------------------------AINNTIA--DKAL 409

  Fly   432 VPGGGT----AFLRCIPYLQELKTESADLQKGVDIVCNALRMPCQTIAQNAGVDGPMVVAKVLNG 492
            |||.|.    |:...:.:...:|.:|   :..|....:||.:..:|:|.|:|.|....:.|:.
  Fly   410 VPGAGAFEVRAYNELVAFKDTIKGKS---RLAVQAFADALLVIPKTLAVNSGYDAQDTIVKLT-- 469

  Fly   493 SED------YGYDAMGDEYCRLVEKGIIDPTKVLRTAITDAAGVAS-LLSTTEVV 540
            .||      .|.|....|..:.|:.|:.|...|.:..:...:.:|| ||...||:
  Fly   470 VEDRLSPELVGLDLATGEPMKPVDLGVYDNYIVKKQILNSCSIIASNLLLVDEVM 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	116/575 (20%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	116/575 (20%)
CCT6	NP_573066.1	chap_CCT_zeta	3..532	CDD:274088	116/575 (20%)
CCT6	NP_573066.1	TCP1_zeta	7..528	CDD:239458	116/575 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453450
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830