DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60B and Cct2

DIOPT Version :9

Sequence 1:	NP_524925.1	Gene:	Hsp60B / 48572	FlyBaseID:	FBgn0011244	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_038934664.1	Gene:	Cct2 / 299809	RGDID:	1359143	Length:	561	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	128/567 - (22%)
Similarity:	215/567 - (37%)	Gaps:	138/567 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GVDILADAVAVTMGPKGRSVIVERPW--TSPKITKDGFTVARSIALKDQHMNLGAKLVQDVADNT 99
            |...:.|.|..|:||||...|:....  .|..:|.||.|:.::|.:.    |..||::.|::...
  Rat    57 GAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGVD----NPAAKVLVDMSRVQ 117

  Fly   100 NESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRRGVMLAVDVVKDKLKEMSKAVE------- 157
            ::..|||||:.||||..:.:|..:.|....:|..|..|...|....::.|  :|.||:
  Rat   118 DDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAAREAL--LSSAVDHGSDEVK 180

  Fly   158 -------------------------TREEIQQVATLSANGDTE----IGRLIGEATDKVGPRG-- 191
                                     |:..::.|..|..:|:.|    |.:|.|...|.....|
  Rat   181 FWQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHVIKKLGGSLADSYLDEGFL 245

  Fly   192 ---TITVKDGKRLKDELNIIQGLRFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLSQIVK 253
               .|.|...||:::...:|.....|...:..|      ||:|.      :.|..|:   ::|..
  Rat   246 LDKKIGVNQPKRIENAKILIANTGMDTDKIKIF------GSRVR------VDSTAKV---AEIEH 295

  Fly   254 GLEQSLRQRRPLIIIAEDISGEALNALVLNKLRLGLQ--------VCAVKSPSY-GHHRKELI-- 307
            ..::.::::      .|.|....:|..:..:|.....        |.|::...: |..|..|:
  Rat   296 AEKEKMKEK------VERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTG 354

  Fly   308 GDISAATGATIFGDDINYSKMEEAKLEDLGQVGEAVISKDSTMLLQGKPKTGLLEMRIQQIQDEL 372
            |:|     |:.| |.....|:...||.:...:||..:...|.:.| |:..|.:|....|||.||
  Rat   355 GEI-----ASTF-DHPELVKLGSCKLIEEVMIGEDKLIHFSGVAL-GEACTIVLRGATQQILDE- 411

  Fly   373 AEKQIKPEQRDRLRQRLSALTKGVAVLHIGGGSEVEVNEKKDRVVDALNATRAAIEEGIVPGGGT 437
            ||:.:    .|.|.. |:...|....::.||.||:.:    ...|..| |:|...:|.:
  Rat   412 AERSL----HDALCV-LAQTVKDPRTVYGGGCSEMLM----AHAVTML-ASRTPGKEAV------ 460

  Fly   438 AFLRCIPYLQELKTESADLQKGVDIVCNALRMPCQTIAQNAGVDGPMVVAKV--------LNGSE 494
                                 .::....||||....||.|||.|...:||::        :....
  Rat   461 ---------------------AMESFAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGRITAGL 504

  Fly   495 DYGYDAMGDEYCRLVEKGIIDPTKVLRTAITDAAGVASLLSTTEVVI 541
            |....::||    :...||.:..:|.|..:..||..|.::...:.:|
  Rat   505 DMKEGSIGD----MAVLGITESFQVKRQVLLSAAEAAEVILRVDNII 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	128/567 (23%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	128/567 (23%)
Cct2	XP_038934664.1	TCP1_beta	37..553	CDD:239452	128/567 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810