DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60B and Cct5

DIOPT Version :9

Sequence 1:	NP_524925.1	Gene:	Hsp60B / 48572	FlyBaseID:	FBgn0011244	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001004078.1	Gene:	Cct5 / 294864	RGDID:	735161	Length:	541	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	107/517 - (20%)
Similarity:	198/517 - (38%)	Gaps:	121/517 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 RAMMIRGVDIL------ADAVAVTM----GPKGRSVIVERPWTSPKITKDGFTVARSIALKDQHM 85
            |...:.|::.|      |.|||.||    ||.|...::........:|.||.|:   :::.|...
  Rat    24 RKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATI---LSMMDVDH 85

  Fly    86 NLGAKLVQDVADNTNESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRRGVMLAVDVVKDKLK 150
            .: |||:.:::.:.::..|||||...|||.|:.:|....:..|.:|:.|..|...|..:....|.
  Rat    86 QI-AKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARIAIQHLD 149

  Fly   151 EMSKAVETREEIQQVATLSANGDTEIGRLIGEATDK----VGPRGTITVKDGKRLKDELNIIQGL 211
            ::|..|..  :|.....|.....|.:|..:..:..:    :.....:||.|.:|...:..:|:
  Rat   150 KISDNVLV--DINNPEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIK-- 210

  Fly   212 RFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLSQIVKGLEQSLRQRRPLIIIAEDISGEA 276
                       |....|.::|.               ::::||           :|:.:|.|...
  Rat   211 -----------VEGKVGGRLED---------------TKLIKG-----------VIVDKDFSHPQ 238

  Fly   277 LNALVLNKLRLGLQVCAVKSP--------------------SYGHHR-KELIGDISAATGATI-- 318
            :...||| .::.:..|..:.|                    .|...: :|:|..|. .|||.:
  Rat   239 MPKEVLN-AKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIAQIK-ETGANLAI 301

  Fly   319 ----FGDDINYSKMEEAKLEDLGQVGEAVISKDSTMLLQGKPKTGLLEMRIQQIQDE-------- 371
                |.|:.|:..::.. |..:..||...|  :...:..|    |.:..|..::..|
  Rat   302 CQWGFDDEANHLLLQNG-LPAVRWVGGPEI--ELIAIATG----GRIVPRFSELTSEKLGFAGVV 359

  Fly   372 -------LAEKQIKPEQRDRLRQRLSALTKGVAVLHIGGGSEVEVNEKKDRVVDALNATRAAIEE 429
                   ..:|.:..||....|    |:|     :.|.||:::.:.|.|..:.|||...|..|.:
  Rat   360 REISFGTTKDKMLVIEQCKNSR----AVT-----IFIRGGNKMIIEEAKRSLHDALCVIRNLIRD 415

  Fly   430 G-IVPGGGTAFLRCIPYLQELKTESADL-QKGVDIVCNALRMPCQTIAQNAGVDGPMVVAKV 489
            . :|.|||.|.:.|...:.:...:...| |..:....:||.:....:::|:|::....:.:|
  Rat   416 NRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEV 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	107/517 (21%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	107/517 (21%)
Cct5	NP_001004078.1	TCP1_epsilon	10..535	CDD:239455	107/517 (21%)
Cct5	NP_001004078.1	Cpn60_TCP1	44..533	CDD:278544	102/497 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810