DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60B and hspd1

DIOPT Version :9

Sequence 1:	NP_524925.1	Gene:	Hsp60B / 48572	FlyBaseID:	FBgn0011244	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_851847.1	Gene:	hspd1 / 282676	ZFINID:	ZDB-GENE-021206-1	Length:	575	Species:	Danio rerio

Alignment Length:	579	Identity:	331/579 - (57%)
Similarity:	437/579 - (75%)	Gaps:	28/579 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 RMYSKDVRFGSGVRAMMIRGVDILADAVAVTMGPKGRSVIVERPWTSPKITKDGFTVARSIALKD 82
            |.|:|||:||:..||:|::|||:||||||||||||||:||:|:.|.|||:||||.|||:||.|||
Zfish    24 RAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKD 88

  Fly    83 QHMNLGAKLVQDVADNTNESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRRGVMLAVDVVKD 147
            ::.|:|||||||||:||||.||||||||||||||:|||||:.|:.||||||||||||:||:.|..
Zfish    89 RYKNIGAKLVQDVANNTNEEAGDGTTTATVLARAVAKEGFDTISKGANPVEIRRGVMMAVEEVIS 153

  Fly   148 KLKEMSKAVETREEIQQVATLSANGDTEIGRLIGEATDKVGPRGTITVKDGKRLKDELNIIQGLR 212
            :||:.||.|.|.|||.||||:|||||||:|.:|..|..|||.:|.|||||||.|.|||.||:|::
Zfish   154 ELKKNSKPVTTPEEIAQVATISANGDTEVGNIISNAMKKVGRKGVITVKDGKTLHDELEIIEGMK 218

  Fly   213 FDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLSQIVKGLEQSLRQRRPLIIIAEDISGEAL 277
            ||.||:||:|:|::||.|.||.:|.|::|.|||:.:..||..||.:.:.|:||:|:|||:.||||
Zfish   219 FDRGYISPYFINTAKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANQHRKPLVIVAEDVDGEAL 283

  Fly   278 NALVLNKLRLGLQVCAVKSPSYGHHRKELIGDISAATGATIFGDDINYSKMEEAKLEDLGQVGEA 342
            :.||||:|::||||.|||:|.:|.:||..:.|::.:||.|:|||:.....:|:.:..|.|:|||.
Zfish   284 STLVLNRLKVGLQVVAVKAPGFGDNRKNQLQDMAVSTGGTVFGDEAMGLALEDIQAHDFGKVGEV 348

  Fly   343 VISKDSTMLLQGKPKTGLLEMRIQQIQDELAEKQIKPEQRDRLRQRLSALTKGVAVLHIGGGSEV 407
            :::||.||||:|:.....:|.|:.:|.::| |......::::|.:||:.|:.||||:.:||.|:|
Zfish   349 IVTKDDTMLLKGRGDASAIEKRVNEIAEQL-ESTNSDYEKEKLNERLAKLSDGVAVIKVGGTSDV 412

  Fly   408 EVNEKKDRVVDALNATRAAIEEGIVPGGGTAFLRCIPYLQELKTESADLQKGVDIVCNALRMPCQ 472
            |||||||||.|||||||||:|||||||||.|.|||||.|..:|..:||.:.|:||:..:||:|..
Zfish   413 EVNEKKDRVTDALNATRAAVEEGIVPGGGCALLRCIPALDNIKPANADQKIGIDIIRRSLRIPAM 477

  Fly   473 TIAQNAGVDGPMVVAKVLNGSEDYGYDAMGDEYCRLVEKGIIDPTKVLRTAITDAAGVASLLSTT 537
            |||:||||:|.:||.|:|..|.:.|||||..||..:||:||||||||:|||:.|||||||||||.
Zfish   478 TIAKNAGVEGSLVVEKILQSSTEIGYDAMNGEYVNMVERGIIDPTKVVRTALLDAAGVASLLSTA 542

  Fly   538 EVVITDSRNDDLLSKLSGAGGGMDDGLDMNMGGLEELAALSGLGGMGGMGGMGGMGGMG 596
            |.|:|:...::                       :|:.|    ||||||||||||||||
Zfish   543 EAVVTEIPKEE-----------------------KEMPA----GGMGGMGGMGGMGGMG 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	313/539 (58%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	310/520 (60%)
hspd1	NP_851847.1	PTZ00114	24..558	CDD:185455	314/557 (56%)
hspd1	NP_851847.1	GroEL	28..548	CDD:239460	310/520 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581495
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61846
OrthoDB	1	1.010	-	-		D183447at33208
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1504
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.720