DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60B and Cct5

DIOPT Version :9

Sequence 1:	NP_524925.1	Gene:	Hsp60B / 48572	FlyBaseID:	FBgn0011244	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_031663.1	Gene:	Cct5 / 12465	MGIID:	107185	Length:	541	Species:	Mus musculus

Alignment Length:	513	Identity:	116/513 - (22%)
Similarity:	200/513 - (38%)	Gaps:	113/513 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 RAMMIRGVDIL------ADAVAVTM----GPKGRSVIVERPWTSPKITKDGFTVARSIALKDQHM 85
            |...:.|::.|      |.|||.||    ||.|...::........||.||.|:   :::.|...
Mouse    24 RKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTITNDGATI---LSMMDVDH 85

  Fly    86 NLGAKLVQDVADNTNESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRRGVMLAVDVVKDKLK 150
            .: |||:.:::.:.::..|||||...|||.|:.:|....:..|.:|:.|..|...|..:....|.
Mouse    86 QI-AKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARIAIQHLD 149

  Fly   151 EMSKAV----ETREEIQQVA--TLSANGDTEIGRLIGEATDKVGPRGTITVKD------------ 197
            ::|..|    ...|.:.|.|  ||.:.......|.:.|    :.....:||.|
Mouse   150 KISDKVLVDINNPEPLIQTAKTTLGSKVINSCHRQMAE----IAVNAVLTVADMERRDVDFELIK 210

  Fly   198 -----GKRLKDELNIIQGLRFDNGYVSPFFVNSSKGSKV------------EFANALVMISLKKI 245
                 |.||:| ..:|:|:..|..:..|........:|:            :..:.|.::|::..
Mouse   211 VEGKVGGRLED-TKLIKGVIVDKDFSHPQMPKKVVDAKIAILTCPFEPPKPKTKHKLDVMSVEDY 274

  Fly   246 TGLSQIVK-GLEQSLRQRRP----LIIIAEDISGEALNALVLNKLRLGLQVCAVKSPSYGHHRKE 305
            ..|.:..| ..|:.::|.:.    |.|.......||.:.|:.|.|.      ||:  ..|....|
Mouse   275 KALQKYEKEKFEEMIKQIKETGANLAICQWGFDDEANHLLLQNGLP------AVR--WVGGPEIE 331

  Fly   306 LIGDISAATGATIFGDDINYSKMEEAKLEDLGQVGEAVI--SKDSTMLLQGKPKTGLLEMRIQQI 368
            |   |:.|||..|..   .:|::...||...|.|.|...  :||..:::: |.|..
Mouse   332 L---IAIATGGRIVP---RFSELTSEKLGFAGVVQEISFGTTKDKMLVIE-KCKNS--------- 380

  Fly   369 QDELAEKQIKPEQRDRLRQRLSALTKGVAVLHIGGGSEVEVNEKKDRVVDALNATRAAIEEG-IV 432
                                 .|:|     :.|.||:::.:.|.|..:.|||...|..|.:. :|
Mouse   381 ---------------------RAVT-----IFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVV 419

  Fly   433 PGGGTAFLRCIPYLQELKTESADL-QKGVDIVCNALRMPCQTIAQNAGVDGPMVVAKV 489
            .|||.|.:.|...:.:...:...| |..:....:||.:....:::|:|::....:.:|
Mouse   420 YGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEV 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	116/513 (23%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	116/513 (23%)
Cct5	NP_031663.1	TCP1_epsilon	10..535	CDD:239455	116/513 (23%)
Cct5	NP_031663.1	Cpn60_TCP1	44..533	CDD:278544	111/493 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810