DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60B and Cct2

DIOPT Version :9

Sequence 1:	NP_524925.1	Gene:	Hsp60B / 48572	FlyBaseID:	FBgn0011244	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001345696.1	Gene:	Cct2 / 12461	MGIID:	107186	Length:	535	Species:	Mus musculus

Alignment Length:	576	Identity:	128/576 - (22%)
Similarity:	214/576 - (37%)	Gaps:	156/576 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GVDILADAVAVTMGPKGRSVIVERPWTSPK-----ITKDGFTVARSIALKDQHMNLGAKLVQDVA 96
            |...:.|.|..|:||||...|:   .:|.:     :|.||.|:.::|.:.    |..||::.|::
Mouse    31 GAIAIGDLVKSTLGPKGMDKIL---LSSGRDAALMVTNDGATILKNIGVD----NPAAKVLVDMS 88

  Fly    97 DNTNESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRRGVMLAVDVVKDKLKEMSKAVE---- 157
            ...::..|||||:.||||..:.:|..:.|....:|..|..|...|....::.|  :|.||:
Mouse    89 RVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIISGWREATKAAREAL--LSSAVDHGSD 151

  Fly   158 ----------------------------TREEIQQVATLSANGDTE----IGRLIGEATDKVGPR 190
                                        |:..::.|..|..:|:.|    |.:|.|...|.....
Mouse   152 EARFWQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHVIKKLGGSLADSYLDE 216

  Fly   191 G-----TITVKDGKRLKDELNIIQGLRFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLSQ 250
            |     .|.|...||:::...:|.....|...:..|      ||:|.      :.|..|:   ::
Mouse   217 GFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIF------GSRVR------VDSTAKV---AE 266

  Fly   251 IVKGLEQSLRQRRPLIIIAEDISGEALNALVLNKLRLGLQ--------VCAVKSPSY-GHHRKEL 306
            |....::.::::      .|.|....:|..:..:|.....        |.|::...: |..|..|
Mouse   267 IEHAEKEKMKEK------VERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLAL 325

  Fly   307 I--GDISAATGATIFGDDINYSKMEEAKLEDLGQVGEAVISKDSTMLLQGKPKTGLLEMRIQQIQ 369
            :  |:|     |:.| |.....|:...||.:...:||..:...|.:.| |:..|.:|....|||.
Mouse   326 VTGGEI-----ASTF-DHPELVKLGSCKLIEEVMIGEDKLIHFSGVAL-GEACTIVLRGATQQIL 383

  Fly   370 DELAEKQIKPEQRDRLRQRLSALTKGVAVLHIGGGSEVEVNEKKDRVVDALNATRAAIEE-GIVP 433
            || ||:.                      ||                 |||......::: ..|.
Mouse   384 DE-AERS----------------------LH-----------------DALCVLAQTVKDPRTVY 408

  Fly   434 GGGTAFLRCIPYLQELKTESADLQKGVDIV-----CNALRMPCQTIAQNAGVDGPMVVAKV---- 489
            |||.:.:    .:....|:.|:...|.:.|     ..||||....||.|||.|...:||::
Mouse   409 GGGCSEM----LMAHAVTQLANRTPGKEAVAMESFAKALRMLPTIIADNAGYDSADLVAQLRAAH 469

  Fly   490 ----LNGSEDYGYDAMGDEYCRLVEKGIIDPTKVLRTAITDAAGVASLLSTTEVVI 541
                :....|.....:||    :...||.:..:|.|..:..||..|.::...:.:|
Mouse   470 SEGHITAGLDMKEGTIGD----MAVLGITESFQVKRQVLLSAAEAAEVILRVDNII 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	128/576 (22%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	128/576 (22%)
Cct2	NP_001345696.1	TCP1_beta	11..527	CDD:239452	128/576 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810