Protein Alignment Hsp60B and CCT6B

DIOPT Version :9

• Sequence 1: NP_524925.1
• Gene: Hsp60B / 48572
• FlyBaseID: FBgn0011244
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_006575.2
• Gene: CCT6B / 10693
• HGNCID: 1621
• Length: 530
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 133/601 - (22%)
• Similarity: 218/601 - (36%)
• Gaps: 151/601 - (25%)

  Fly     8 KAITSSRCFARMYSKDVRFGSGVRAMMIRGVDILADAVAVTMGPKGRSVIVERPWTSPKITKDGF 72
            ||:.|....||     .|....|.....||   |.|.:...:||||...::.......|:||||.
Human     5 KAVNSKAEVAR-----ARAALAVNICAARG---LQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGN 61

  Fly    73 TVARSIALKDQHMNLGAKLVQDVADNTNESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRRG 137
            .:...:.:  ||..  |.|:..||...::..|||||:..::...:.|:....|:.|.:|..|..|
Human    62 VLLDEMQI--QHPT--ASLIAKVATAQDDVTGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEG 122

  Fly   138 VMLAVDVVKDKLKEMSKAVETREEIQQVATLSANGDTEIGRLIGEATDKVGPRGTITVKDGKRLK 202
                .:..|.|..|:.:.|:..:|:::...|..                  .|.::..|....|.
Human   123 ----FEAAKIKALEVLEEVKVTKEMKRKILLDV------------------ARTSLQTKVHAELA 165

  Fly   203 DELNIIQGLRFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLSQIVKGLEQSLRQRRPLII 267
            |.|..:        .|.........|..::.....:|....|:...:::::||......|.|
Human   166 DVLTEV--------VVDSVLAVRRPGYPIDLFMVEIMEMKHKLGTDTKLIQGLVLDHGARHP--- 219

  Fly   268 IAEDISGEALNALVLNKLRLGLQVCAVKSPSYGHHRKELIGDISAATGATIFGDDINYSKMEEAK 332
               |:.....:|.:|        :|.|   |..:.:.|:.......|..    :.....|.|...
Human   220 ---DMKKRVEDAFIL--------ICNV---SLEYEKTEVNSGFFYKTAE----EKEKLVKAERKF 266

  Fly   333 LEDLGQVGEAVISKDSTMLLQGKPKTGLLEMRIQQIQ----DELAEKQIKPEQRDRLR--QRLSA 391
            :||  :|.:.:..||.......|   |.:.:..:.|.    |.||:..|...:|.:.|  :|||.
Human   267 IED--RVQKIIDLKDKVCAQSNK---GFVVINQKGIDPFSLDSLAKHGIVALRRAKRRNMERLSL 326

  Fly   392 LTKGVAV----------------------------------------LHIGGGSEVEVNEKKDRV 416
            ...|:||                                        |.:.|.::..:.:.||.:
Human   327 ACGGMAVNSFEDLTVDCLGHAGLVYEYTLGEEKFTFIEECVNPCSVTLLVKGPNKHTLTQVKDAI 391

  Fly   417 VDALNATRAAIEEG-IVPGGGTAFL----RCIPYLQELKTESADLQKGVDIVCNALRMPCQTIAQ 476
            .|.|.|.:.|||:| :|||.|...:    ..:.|...:|..:   :.||....:||.:..:.:||
Human   392 RDGLRAIKNAIEDGCMVPGAGAIEVAMAEALVTYKNSIKGRA---RLGVQAFADALLIIPKVLAQ 453

  Fly   477 NAGVDGPMVVAKV--------------LNGSE-----DYGYDAMGDEYCRLVEKGIIDPTKVLRT 522
            |||.|....:.||              ||..|     |.|   :.|.||  |:|.::....|:.|
Human   454 NAGYDPQETLVKVQAEHVESKQLVGVDLNTGEPMVAADAG---VWDNYC--VKKQLLHSCTVIAT 513

  Fly   523 AI--TD---AAGVASL 533
            .|  .|   .||::||
Human   514 NILLVDEIMRAGMSSL 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	132/600 (22%)
		GroEL	22..543	CDD:239460	128/587 (22%)
CCT6B	NP_006575.2	chap_CCT_zeta	3..530	CDD:274088	133/601 (22%)
		TCP1_zeta	23..526	CDD:239458	123/573 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810