DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60B and CCT4

DIOPT Version :9

Sequence 1:	NP_524925.1	Gene:	Hsp60B / 48572	FlyBaseID:	FBgn0011244	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_006421.2	Gene:	CCT4 / 10575	HGNCID:	1617	Length:	539	Species:	Homo sapiens

Alignment Length:	557	Identity:	118/557 - (21%)
Similarity:	236/557 - (42%)	Gaps:	95/557 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VRAMMIRGVDILADAVAVTMGPKGRSVIVERPWTSPKITKDGFTVARSIALKDQHMNLGAKLVQD 94
            :|...|.....:|||:..::||||...:::.......||.||.|:.:.:    |.::..|:::.:
Human    33 IRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQM----QVLHPAARMLVE 93

  Fly    95 VADNTNESAGDGTTTATVLARAIAKEGFNQITMGANPVEIRRGVMLAVDVVKDKLKEMSKAVE-- 157
            ::...:..||||||:..::|.::.......:..|.:|..|......|::...:.|.:||:.||
Human    94 LSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPVELS 158

  Fly   158 TREEIQQVATLSANGDTEIGRLIGEATDKVGPRG--------------TITVKDGKRLK------ 202
            .||.:...||.|.|     .:::.:.:..:.|..              ::.::|.|.:|
Human   159 DRETLLNSATTSLN-----SKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTI 218

  Fly   203 DELNIIQGL----RFDNGYVSPFFVNSSKGSKVEFANALVMISLKKITGLSQIVKG----LEQSL 259
            |:..:::||    :..|..::.  |..:|...::|.     :|..|....:|||..    :::.|
Human   219 DDCELVEGLVLTQKVSNSGITR--VEKAKIGLIQFC-----LSAPKTDMDNQIVVSDYAQMDRVL 276

  Fly   260 RQRRPLII-IAEDISGEALNALVLNKLRLGLQVCAVKSPSYGHHRKELIGDISAATGATIFGDDI 323
            |:.|..|: :.:.|.....|.|::.|..|                ::.:.|:     |..|.:.:
Human   277 REERAYILNLVKQIKKTGCNVLLIQKSIL----------------RDALSDL-----ALHFLNKM 320

  Fly   324 NYSKMEEAKLEDLGQVGEAVISKDSTMLLQGKPKTGLLEMRIQQI-QDELAEKQIKPEQRDRLRQ 387
            ....:::.:.||:    |.:.....|     ||...:.:.....: ..|||| ::......:|.:
Human   321 KIMVIKDIEREDI----EFICKTIGT-----KPVAHIDQFTADMLGSAELAE-EVNLNGSGKLLK 375

  Fly   388 RLSALTKGVAVLHIGGGSEVEVNEKKDRVV-DALNATRAAIEE-GIVPGGGTAFLRCIPYLQELK 450
            .....:.|..|..:..||...|.|:.:|.: |||...|..::: .::.|||...:.....|
Human   376 ITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRL---- 436

  Fly   451 TESADLQKGVDIVC-----NALRMPCQTIAQNAGVDGPMVVAKVLN----GSEDYGYDAMGDEYC 506
            ||.:....|::..|     :|:.:...|:|:|||::....|.::.|    |.:..|.:.......
Human   437 TEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGIS 501

  Fly   507 RLVEKGIIDPTKVLRTAITDAA-GVASLLSTTEVVIT 542
            .::|:.::.|..|..:|:|.|. .|.|:|...:||.|
Human   502 NILEELVVQPLLVSVSALTLATETVRSILKIDDVVNT 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60B	NP_524925.1	PTZ00114	9..558	CDD:185455	118/557 (21%)
Hsp60B	NP_524925.1	GroEL	22..543	CDD:239460	118/557 (21%)
CCT4	NP_006421.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
CCT4	NP_006421.2	TCP1_delta	25..538	CDD:239454	117/555 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810