Protein Alignment heph and PTBP3

DIOPT Version :9

• Sequence 1: NP_001247399.1
• Gene: heph / 48571
• FlyBaseID: FBgn0011224
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: XP_011517567.1
• Gene: PTBP3 / 9991
• HGNCID: 10253
• Length: 561
• Species: Homo sapiens
• Alignment Length: 630
• Identity: 313/630 - (49%)
• Similarity: 389/630 - (61%)
• Gaps: 100/630 - (15%)

  Fly   296 PSPTSLHLSSPKKVRIDEQYIYKLNYLRGSDELLSQAAVMAPASDN----------NNQDLATKK 350
            |||.||    |||:.       :|:..||||||||...:..|.:.|          |..|....|
Human     5 PSPFSL----PKKLN-------ELSARRGSDELLSSGIINGPFTMNSSTPSTGVYANGNDSKKFK 58

  Fly   351 AKLEPGTVLAGGIAKASKVIHLRNIPNESGEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEIS 415
            ....|        ...|:|:|||.||.:..||::|:||:|||:|||:|:||||:|||:|||.|.:
Human    59 RDRPP--------CSPSRVLHLRKIPCDVTEAEIISLGLPFGKVTNLLMLKGKSQAFLEMASEEA 115

  Fly   416 ATSMVSCYTVTPPQMRGRMVYVQFSNHRELKTDQGHNNSTAHSDYSVQSPASGSPLPLSAAANAT 480
            |.:||:.||...|.:|.:.||:|:|||||||||.                     ||..|.|.|.
Human   116 AVTMVNYYTPITPHLRSQPVYIQYSNHRELKTDN---------------------LPNQARAQAA 159

  Fly   481 SNNANSSSDSNSAMGILQNTSAVNAGGNTNAAGGPNT----------VLRVIVESLMYPVSLDIL 535
                            ||..|||.: |:...:|||:.          |||:|:|:|.|||:|::|
Human   160 ----------------LQAVSAVQS-GSLALSGGPSNEGTVLPGQSPVLRIIIENLFYPVTLEVL 207

  Fly   536 HQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSLLDGQNIYNGCCTLRIDNSKLTALNV 600
            ||||.::|.||||:||||||.||||:||.|..:|.:||..||||||||.|||||||.||||:|||
Human   208 HQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNV 272

  Fly   601 KYNNDKSRDFTNPALPPGEPGVDIMPTAGGLMNTNDLLLIAARQRPS-LSVNGLGAPGVLP---- 660
            |||||||||||...||.|:....:.|.           :.||...|. :|....||.|..|
Human   273 KYNNDKSRDFTRLDLPTGDGQPSLEPP-----------MAAAFGAPGIISSPYAGAAGFAPAIGF 326

  Fly   661 PFALGLGTPLTGGYNNALPNLAAFSLANSGALQTTAPAMRGY--SNVLLVSNLNEEMVTPDALFT 723
            |.|.||..|...|   ||..|...|.|.:|.:  ..|...|.  ::||||:|||.:::||..||.
Human   327 PQATGLSVPAVPG---ALGPLTITSSAVTGRM--AIPGASGIPGNSVLLVTNLNPDLITPHGLFI 386

  Fly   724 LFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAMSHLDKLRLWGKPIRVMASKHQAVQLPKEGQ 788
            ||||||||.||||::|||::||:|||:..||.|||:||...||:||.:|...|||||||||:|||
Human   387 LFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRLYGKVLRATLSKHQAVQLPREGQ 451

  Fly   789 PDAGLTRDYSQNPLHRFKKPGSKNYQNIYPPSATLHLSNIPSSCSEDDIKEAFTSNSFEVKAFKF 853
            .|.|||:|:|.:||||||||||||:|||:||||||||||||.|.:.||:|..|......||||||
Human   452 EDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTVDDLKNLFIEAGCSVKAFKF 516

  Fly   854 FPKDRKMALLQLLSVEEAVLALIKMHNHQLSESNHLRVSFSKSNI 898
            |.|||||||:||.|||||:.|||::|||.|.|::|||||||||.|
Human   517 FQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
heph	NP_001247399.1	hnRNP-L_PTB	366..898	CDD:273733	289/548 (53%)
		RRM1_PTBP1_like	368..448	CDD:241132	46/79 (58%)
		RRM2_PTBP1_like	516..611	CDD:241137	67/104 (64%)
		RRM3_PTBP1_like	705..778	CDD:240869	44/72 (61%)
		RRM4_PTBP1_like	822..897	CDD:240871	50/74 (68%)
PTBP3	XP_011517567.1	hnRNP-L_PTB	66..561	CDD:273733	289/548 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4752
eggNOG	1	0.900	-	-		E1_KOG1190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	545	1.000	Inparanoid score	I1164
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58575
OrthoDB	1	1.010	-	-		D1545178at2759
OrthoFinder	1	1.000	-	-		FOG0001151
OrthoInspector	1	1.000	-	-		otm41607
orthoMCL	1	0.900	-	-		OOG6_101075
Panther	1	1.100	-	-	O	PTHR15592
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4107
SonicParanoid	1	1.000	-	-		X703
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870