DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment heph and Ptbp3

DIOPT Version :9

Sequence 1:	NP_001247399.1	Gene:	heph / 48571	FlyBaseID:	FBgn0011224	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_112636.1	Gene:	Ptbp3 / 83515	RGDID:	621671	Length:	523	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	295/578 - (51%)
Similarity:	370/578 - (64%)	Gaps:	82/578 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 ASDNNNQDLATKKAKLEPGTVLAGGIAKASKVIHLRNIPNESGEADVIALGIPFGRVTNVLVLKG 402
            |:.|:|:.....:....|           |:|:|||.||.:..||:||:||:|||:|||:|:|||
  Rat    11 ANGNDNKKFKGDRPPCSP-----------SRVLHLRKIPCDVTEAEVISLGLPFGKVTNLLMLKG 64

  Fly   403 KNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRELKTDQGHNNSTAHSDYSVQSPAS 467
            |:|||:|||.|.:|.:|::.||...|.:|.:.||:|:|||||||||.
  Rat    65 KSQAFLEMASEEAAVTMINYYTPVTPHLRSQPVYIQYSNHRELKTDN------------------ 111

  Fly   468 GSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAG-----GNTNAAG----GPNTVLRVIV 523
               ||..|.|.|.                ||..|||.:|     |.|:..|    |.:.|||:|:
  Rat   112 ---LPNQARAQAA----------------LQAVSAVQSGNLSLPGATSNEGTLLPGQSPVLRIII 157

  Fly   524 ESLMYPVSLDILHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSLLDGQNIYNGCCTL 588
            |:|.|||:|::|||||.::|.||||:||||||.||||:||.|..:||:||..||||||||.||||
  Rat   158 ENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAQYAKMALDGQNIYNACCTL 222

  Fly   589 RIDNSKLTALNVKYNNDKSRDFTNPALPPGEPGVDIMPT------AGGLMNTNDLLLIAARQRPS 647
            |||.||||:||||||||||||||...||.|:....:.|.      |.|:|::           |.
  Rat   223 RIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIMSS-----------PY 276

  Fly   648 LSVNGLGAPGVLPPFALGLGTPLTGGYNNALPNLAAFSLANSGALQTTAPAMRGY--SNVLLVSN 710
            ....|. ||.:..|.|.||......|   ||..|...|.|.||.:  ..|...|.  ::||||:|
  Rat   277 AGAAGF-APAIAFPQAAGLSVSAVPG---ALGPLTLTSSAVSGRM--AIPGASGIPGNSVLLVTN 335

  Fly   711 LNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAMSHLDKLRLWGKPIRVMA 775
            ||.:.:||..||.||||||||.||||::|||::||:|||:..||.:||:||...||:||.:|...
  Rat   336 LNPDFITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADASQAQIAMNHLSGQRLYGKVLRATL 400

  Fly   776 SKHQAVQLPKEGQPDAGLTRDYSQNPLHRFKKPGSKNYQNIYPPSATLHLSNIPSSCSEDDIKEA 840
            |||||||||:|||.|.|||:|:|.:||||||||||||:|||:||||||||||||.|.:.||:|..
  Rat   401 SKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTMDDLKNL 465

  Fly   841 FTSNSFEVKAFKFFPKDRKMALLQLLSVEEAVLALIKMHNHQLSESNHLRVSFSKSNI 898
            ||.....|||||||.|||||||:||.|||||:.|||::|||.|.|::|||||||||.|
  Rat   466 FTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
heph	NP_001247399.1	hnRNP-L_PTB	366..898	CDD:273733	290/548 (53%)
		RRM1_PTBP1_like	368..448	CDD:241132	46/79 (58%)
		RRM2_PTBP1_like	516..611	CDD:241137	68/94 (72%)
		RRM3_PTBP1_like	705..778	CDD:240869	43/72 (60%)
		RRM4_PTBP1_like	822..897	CDD:240871	51/74 (69%)
Ptbp3	NP_112636.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		3/13 (23%)
		hnRNP-L_PTB	28..523	CDD:273733	291/559 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..426		13/19 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4630
eggNOG	1	0.900	-	-		E1_KOG1190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	545	1.000	Inparanoid score	I1111
OMA	1	1.010	-	-		QHG58575
OrthoDB	1	1.010	-	-		D1545178at2759
OrthoFinder	1	1.000	-	-		FOG0001151
OrthoInspector	1	1.000	-	-		otm45730
orthoMCL	1	0.900	-	-		OOG6_101075
Panther	1	1.100	-	-	O	PTHR15592
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X703
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840