DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment heph and PTB1

DIOPT Version :9

Sequence 1:	NP_001247399.1	Gene:	heph / 48571	FlyBaseID:	FBgn0011224	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_186764.1	Gene:	PTB1 / 821129	AraportID:	AT3G01150	Length:	399	Species:	Arabidopsis thaliana

Alignment Length:	497	Identity:	141/497 - (28%)
Similarity:	202/497 - (40%)	Gaps:	171/497 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 SKVIHLRNIPNESGEADVIALGIPFGRVTNVL--VLKGKNQAFIEMADEISATSMVSCYTVT--P 427
            |||:||||:|.|..|.::|.|...||::.|..  |...:||||:|.||...|.||||.|..:  |
plant    16 SKVVHLRNLPWECVEEELIDLCKRFGKIVNTKSNVGANRNQAFVEFADLNQAISMVSYYASSSEP 80

  Fly   428 PQMRGRMVYVQFSNHRELKTDQGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNS 492
            .|:||:.||:|:||..|:.     ||         |||
plant    81 AQIRGKTVYIQYSNRHEIV-----NN---------QSP--------------------------- 104

  Fly   493 AMGILQNTSAVNAGGNTNAAGGPNTVLRVIVESL-MYPVSLDILHQIFQRYGKVLKIVTFTKNNS 556
                          |:.     |..||.|..|.: .:.||:|::|.:|..:|.|.||.||.|...
plant   105 --------------GDV-----PGNVLLVTFEGVESHEVSIDVIHLVFSAFGFVHKIATFEKAAG 150

  Fly   557 FQALIQYPDANSAQHAKSLLDGQNI-------YNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPA 614
            ||||:|:.|..:|..|:|.|||::|       :.|.|:||:..|..|.||:|:.:.:|||:|||.
plant   151 FQALVQFTDVETASAARSALDGRSIPRYLLSAHVGSCSLRMSYSAHTDLNIKFQSHRSRDYTNPY 215

  Fly   615 LPPGEPGVDIMPTAGGLMNTNDLLLIAARQRPSLSVNGLGAPGVLPPFALGLGTPLTGGYNNALP 679
            ||..:..:|      |.|            :|:|..:|
plant   216 LPVNQTAMD------GSM------------QPALGADG--------------------------- 235

  Fly   680 NLAAFSLANSGALQTTAPAMRGYSNVL--LVSNLNEEMVTPDALFTLFGVYGDVQRVKIL-YNKK 741
                             ..:...||||  |:.|: :..||.|.|.|:|..||.||::.|. .|..
plant   236 -----------------KKVESQSNVLLGLIENM-QYAVTVDVLHTVFSAYGTVQKIAIFEKNGS 282

  Fly   742 DSALIQMAEPQQAYLAMSHLD----------KLRL-----WGKPIRVMASKHQAVQLP------- 784
            ..||||.::...|.:|...|:          ||||     ....::..:.|.:...||
plant   283 TQALIQYSDIPTAAMAKEALEGHCIYDGGYCKLRLSYSRHTDLNVKAFSDKSRDYTLPDLSLLVA 347

  Fly   785 KEG------QPDAGLTRDYSQNPLHRFKKPGSKNYQNIYPPS 820
            ::|      .|.||.     |||..:.:..|......:||.|
plant   348 QKGPAVSGSAPPAGW-----QNPQAQSQYSGYGGSPYMYPSS 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
heph	NP_001247399.1	hnRNP-L_PTB	366..898	CDD:273733	141/497 (28%)
		RRM1_PTBP1_like	368..448	CDD:241132	38/83 (46%)
		RRM2_PTBP1_like	516..611	CDD:241137	41/102 (40%)
		RRM3_PTBP1_like	705..778	CDD:240869	27/90 (30%)
		RRM4_PTBP1_like	822..897	CDD:240871
PTB1	NP_186764.1	RRM1_PTBPH1_PTBPH2	15..95	CDD:410087	37/78 (47%)
		RRM2_PTBPH1_PTBPH2	109..203	CDD:241135	37/93 (40%)
		RRM3_PTBPH1_PTBPH2	242..338	CDD:410091	30/96 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1545178at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15592
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880