DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment heph and PTBP2

DIOPT Version :9

Sequence 1:	NP_001247399.1	Gene:	heph / 48571	FlyBaseID:	FBgn0011224	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001287916.1	Gene:	PTBP2 / 58155	HGNCID:	17662	Length:	548	Species:	Homo sapiens

Alignment Length:	609	Identity:	301/609 - (49%)
Similarity:	382/609 - (62%)	Gaps:	100/609 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 EQYIYKLNYLRGSDELLSQAAVMAPASD--------NNNQDLATKKAKLEPGTVLAGGIAKASKV 369
            ::|:...|  ||||||||.:.:.:|.|:        |.|.   :||.|.|  ..:.|.   .|:|
Human    17 KKYVTVNN--RGSDELLSGSVLSSPNSNMSSMVVTANGND---SKKFKGE--DKMDGA---PSRV 71

  Fly   370 IHLRNIPNESGEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRM 434
            :|:|.:|.|..|.:|||||:|||:|||:|:||||||||:|:|.|.:|.:||:.|:...|.:|.:.
Human    72 LHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQP 136

  Fly   435 VYVQFSNHRELKTDQGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQN 499
            :|:|:|||:|||||                                 |..|     ..|..:||.
Human   137 IYIQYSNHKELKTD---------------------------------NTLN-----QRAQAVLQA 163

  Fly   500 TSAVNAGGNTNAAG----------GPNTVLRVIVESLMYPVSLDILHQIFQRYGKVLKIVTFTKN 554
            .:||.. .||..:|          ..:.|||:|::::.|||:||:|||||.::|.||||:|||||
Human   164 VTAVQT-ANTPLSGTTVSESAVTPAQSPVLRIIIDNMYYPVTLDVLHQIFSKFGAVLKIITFTKN 227

  Fly   555 NSFQALIQYPDANSAQHAKSLLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALP--P 617
            |.||||:||.|..:||.||..||||||||.|||||||.|||..||||||||||||:|.|.||  .
Human   228 NQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTRPDLPSGD 292

  Fly   618 GEPGVDIMPTAGGLMNTNDLLLIAARQRPSLSVNGL---GAPGVLPPFALGLGTPLTGGYNNALP 679
            |:|.:|  |.            |||......|:.||   ..||.|.|.              |:|
Human   293 GQPALD--PA------------IAAAFAKETSLLGLPVAAVPGALSPL--------------AIP 329

  Fly   680 NLAAFSLANSGALQTTAPAMRGYSNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSA 744
            |.||.:.|.:...........|.:.||||||||||||||.:||||||||||||||||||||||||
Human   330 NAAAAAAAAAAGRVGMPGVSAGGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSA 394

  Fly   745 LIQMAEPQQAYLAMSHLDKLRLWGKPIRVMASKHQAVQLPKEGQPDAGLTRDYSQNPLHRFKKPG 809
            |||||:..|:.|||:||:..:::||.|||..||||.||||:||..|.|||:|:..:|||||||||
Human   395 LIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTVQLPREGLDDQGLTKDFGNSPLHRFKKPG 459

  Fly   810 SKNYQNIYPPSATLHLSNIPSSCSEDDIKEAFTSNSFEVKAFKFFPKDRKMALLQLLSVEEAVLA 874
            |||:|||:||||||||||||.|.:|:|::..|.:....|||||||.:|.||||||:.:||||:.|
Human   460 SKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQRDHKMALLQMATVEEAIQA 524

  Fly   875 LIKMHNHQLSESNHLRVSFSKSNI 898
            ||.:||:.|.|::|||||||||.|
Human   525 LIDLHNYNLGENHHLRVSFSKSTI 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
heph	NP_001247399.1	hnRNP-L_PTB	366..898	CDD:273733	281/546 (51%)
		RRM1_PTBP1_like	368..448	CDD:241132	43/79 (54%)
		RRM2_PTBP1_like	516..611	CDD:241137	66/94 (70%)
		RRM3_PTBP1_like	705..778	CDD:240869	55/72 (76%)
		RRM4_PTBP1_like	822..897	CDD:240871	45/74 (61%)
PTBP2	NP_001287916.1	hnRNP-L_PTB	68..548	CDD:273733	281/546 (51%)
		RRM1_PTBP2	69..150	CDD:241222	44/80 (55%)
		RRM2_PTBP1_like	189..284	CDD:241137	66/94 (70%)
		RRM3_PTBP2	341..447	CDD:241140	69/105 (66%)
		RRM4_PTBP2	468..548	CDD:241146	50/79 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149696
Domainoid	1	1.000	140	1.000	Domainoid score	I4752
eggNOG	1	0.900	-	-		E1_KOG1190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	545	1.000	Inparanoid score	I1164
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58575
OrthoDB	1	1.010	-	-		D1545178at2759
OrthoFinder	1	1.000	-	-		FOG0001151
OrthoInspector	1	1.000	-	-		otm41607
orthoMCL	1	0.900	-	-		OOG6_101075
Panther	1	1.100	-	-	O	PTHR15592
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4107
SonicParanoid	1	1.000	-	-		X703
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800