Protein Alignment heph and PTBP1

DIOPT Version :10

• Sequence 1: NP_001247399.1
• Gene: heph / 48571
• FlyBaseID: FBgn0011224
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: NP_001398069.1
• Gene: PTBP1 / 5725
• HGNCID: 9583
• Length: 559
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 326/604 - (53%)
• Similarity: 396/604 - (65%)
• Gaps: 88/604 - (14%)

  Fly   323 RGSDELLSQAAVMAP-------ASDNNNQDLATKKAKLEPGTVLAGGIAKASKVIHLRNIPNESG 380
            ||||||.|......|       ||..|..|  :||.|   |...:.|:  .|:|||:|.:|.:..
Human    16 RGSDELFSTCVTNGPFIMSSNSASAANGND--SKKFK---GDSRSAGV--PSRVIHIRKLPIDVT 73

  Fly   381 EADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHREL 445
            |.:||:||:|||:|||:|:|||||||||||..|.:|.:||:.||...|.:||:.:|:|||||:||
Human    74 EGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKEL 138

  Fly   446 KTDQGHNNSTAHSD-YSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNT 509
            |||...|.:.|.:. .:|.|..||:   |:.||:|                     :||:||
Human   139 KTDSSPNQARAQAALQAVNSVQSGN---LALAASA---------------------AAVDAG--- 176

  Fly   510 NAAGGPNTVLRVIVESLMYPVSLDILHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKS 574
            .|..|.:.|||:|||:|.|||:||:|||||.::|.||||:||||||.||||:||.|..||||||.
Human   177 MAMAGQSPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKL 241

  Fly   575 LLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALPPGEPGVDIMPTAGGLMNTNDLLL 639
            .||||||||.|||||||.||||:||||||||||||:|.|.||.|    |..|:.       |..:
Human   242 SLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTRPDLPSG----DSQPSL-------DQTM 295

  Fly   640 IAARQRPSLSVNGLGAPGVL--PPFALGLGTPLTGGYNNALPNLAAFSLAN-SGALQTTA----- 696
            .||          .||||::  .|:| |.|.|.|    .|:|..|..|:.| .|||...|
Human   296 AAA----------FGAPGIISASPYA-GAGFPPT----FAIPQAAGLSVPNVHGALAPLAIPSAA 345

  Fly   697 -----------PAMRGYSN-VLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMA 749
                       |.:.|..| ||||||||.|.|||.:||.||||||||||||||:|||::||:|||
Human   346 AAAAAAGRIAIPGLAGAGNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVKILFNKKENALVQMA 410

  Fly   750 EPQQAYLAMSHLDKLRLWGKPIRVMASKHQAVQLPKEGQPDAGLTRDYSQNPLHRFKKPGSKNYQ 814
            :..||.||||||:..:|.|||||:..||||.||||:|||.|.|||:||..:||||||||||||:|
Human   411 DGNQAQLAMSHLNGHKLHGKPIRITLSKHQNVQLPREGQEDQGLTKDYGNSPLHRFKKPGSKNFQ 475

  Fly   815 NIYPPSATLHLSNIPSSCSEDDIKEAFTSNSFEVKAFKFFPKDRKMALLQLLSVEEAVLALIKMH 879
            ||:||||||||||||.|.||:|:|..|:||...||.||||.|||||||:|:.||||||.|||.:|
Human   476 NIFPPSATLHLSNIPPSVSEEDLKVLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIDLH 540

  Fly   880 NHQLSESNHLRVSFSKSNI 898
            ||.|.|::|||||||||.|
Human   541 NHDLGENHHLRVSFSKSTI 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
heph	NP_001247399.1	hnRNP-L_PTB	366..898	CDD:273733	308/552 (56%)
PTBP1	NP_001398069.1	hnRNP-L_PTB	59..559	CDD:273733	308/552 (56%)