Protein Alignment heph and ptbp2b

DIOPT Version :9

• Sequence 1: NP_001247399.1
• Gene: heph / 48571
• FlyBaseID: FBgn0011224
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: NP_001093477.1
• Gene: ptbp2b / 562434
• ZFINID: ZDB-GENE-060810-49
• Length: 538
• Species: Danio rerio
• Alignment Length: 590
• Identity: 289/590 - (48%)
• Similarity: 383/590 - (64%)
• Gaps: 79/590 - (13%)

  Fly   323 RGSDELLSQAAVMAPASDNNNQDLATKKAKLEPGTVLAGGIAKASKVIHLRNIPNESGEADVIAL 387
            |.||:|||.:...:|.|........:||.::|...     .:..|:|||:|.:|||..|.:||||
Zfish    14 RSSDDLLSGSLYSSPNSSVTANGSDSKKLRVEDSM-----DSPPSRVIHIRKLPNEVSETEVIAL 73

  Fly   388 GIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRELKTDQGHN 452
            |:|||:|||:|:||||||||:|:..|.:|.:||:.||...||:|...|::|:|||:|||||...|
Zfish    74 GLPFGKVTNILMLKGKNQAFLELGTEEAAVTMVNYYTAVTPQVRNVPVFIQYSNHKELKTDSALN 138

  Fly   453 NSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNTNA------ 511
                                                  ..|..:||..|||..||:.::
Zfish   139 --------------------------------------QRAQAVLQAVSAVQEGGSPSSDMASKS 165

  Fly   512 --AGGPNTVLRVIVESLMYPVSLDILHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKS 574
              ...|:.|||:|::::.|||:||:|.|||.::|.|:||:||||||.||||:|:.|..:||.||.
Zfish   166 VLTPAPSPVLRIIIDNMFYPVTLDVLQQIFSKFGTVMKIITFTKNNQFQALLQFSDPVNAQQAKL 230

  Fly   575 LLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALP--PGEPGVDIMPTAGGLMNTNDL 637
            .||||||||.|||||||.|||..||||||||||||:|.|.||  .|:|.||  |:....:
Zfish   231 SLDGQNIYNSCCTLRIDFSKLVNLNVKYNNDKSRDYTRPELPAGDGQPPVD--PSMAAAL----- 288

  Fly   638 LLIAARQRPSLSVNGLGAP-GVLPPFALGLGTPLTGGYNNALPNLAAFSLANSGALQTTAPAMRG 701
                ::..|||    ||.| |::..::.|      ||:.::|..::..|.|.:.|......|:.|
Zfish   289 ----SKDSPSL----LGTPSGMVTSYSSG------GGFPSSLGAISPLSAAAAAAAAAGRVALSG 339

  Fly   702 YS---NVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAMSHLDK 763
            :|   .||||||||:|||||.:||||||||||||||||||||||||||||::..||.||||||:.
Zfish   340 HSVPGGVLLVSNLNDEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMSDGNQAQLAMSHLNG 404

  Fly   764 LRLWGKPIRVMASKHQAVQLPKEGQPDAGLTRDYSQNPLHRFKKPGSKNYQNIYPPSATLHLSNI 828
            .:::||.|||..||||.||||:||..|.|||:|::.:||||||||||||:|||:|||||||||||
Zfish   405 QKMYGKIIRVTLSKHQTVQLPREGLDDQGLTKDFTSSPLHRFKKPGSKNFQNIFPPSATLHLSNI 469

  Fly   829 PSSCSEDDIKEAFTSNSFEVKAFKFFPKDRKMALLQLLSVEEAVLALIKMHNHQLSESNHLRVSF 893
            |.:.:|:|::..|:::...||||||| :||||:|||:.:.|||:.|||.:||:.:...:.|||||
Zfish   470 PDNVTEEDLRLLFSNSGGTVKAFKFF-QDRKMSLLQMATAEEAIQALIDLHNYDMGRGHRLRVSF 533

  Fly   894 SKSNI 898
            |||.|
Zfish   534 SKSTI 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
heph	NP_001247399.1	hnRNP-L_PTB	366..898	CDD:273733	277/545 (51%)
		RRM1_PTBP1_like	368..448	CDD:241132	46/79 (58%)
		RRM2_PTBP1_like	516..611	CDD:241137	63/94 (67%)
		RRM3_PTBP1_like	705..778	CDD:240869	55/72 (76%)
		RRM4_PTBP1_like	822..897	CDD:240871	40/74 (54%)
ptbp2b	NP_001093477.1	hnRNP-L_PTB	52..538	CDD:273733	277/545 (51%)
		RRM1_PTBP2	53..134	CDD:241222	47/80 (59%)
		RRM2_PTBP1_like	172..267	CDD:241137	63/94 (67%)
		RRM3_PTBP2	333..438	CDD:241140	71/104 (68%)
		RRM_SF	459..538	CDD:302621	45/79 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583829
Domainoid	1	1.000	140	1.000	Domainoid score	I4697
eggNOG	1	0.900	-	-		E1_KOG1190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	527	1.000	Inparanoid score	I1195
OMA	1	1.010	-	-		QHG58575
OrthoDB	1	1.010	-	-		D1545178at2759
OrthoFinder	1	1.000	-	-		FOG0001151
OrthoInspector	1	1.000	-	-		otm25002
orthoMCL	1	0.900	-	-		OOG6_101075
Panther	1	1.100	-	-	O	PTHR15592
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X703
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770