Protein Alignment heph and Ptbp2

DIOPT Version :9

• Sequence 1: NP_001247399.1
• Gene: heph / 48571
• FlyBaseID: FBgn0011224
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: XP_006501794.1
• Gene: Ptbp2 / 56195
• MGIID: 1860489
• Length: 537
• Species: Mus musculus
• Alignment Length: 595
• Identity: 297/595 - (49%)
• Similarity: 376/595 - (63%)
• Gaps: 90/595 - (15%)

  Fly   323 RGSDELLSQAAVMAPASD--------NNNQDLATKKAKLEPGTVLAGGIAKASKVIHLRNIPNES 379
            ||||||||.:.:.:|.|:        |.|.   :||.|.|  ..:.|.   .|:|:|:|.:|.|.
Mouse    14 RGSDELLSGSVLSSPNSNMSGMVVTANGND---SKKFKGE--DKMDGA---PSRVLHIRKLPGEV 70

  Fly   380 GEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRE 444
            .|.:|||||:|||:|||:|:||||||||:|:|.|.:|.:||:.|:...|.:|.:.:|:|:|||:|
Mouse    71 TETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKE 135

  Fly   445 LKTDQGHNN------STAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAV 503
            ||||...|.      ....:..:..:|.||:.:..||...|.|
Mouse   136 LKTDNTLNQRAQVVLQAVTAVQTANTPLSGTTVSESAVTPAQS---------------------- 178

  Fly   504 NAGGNTNAAGGPNTVLRVIVESLMYPVSLDILHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANS 568
                         .|||:|::::.|||:||:|||||.::|.||||:||||||.||||:||.|..:
Mouse   179 -------------PVLRIIIDNMYYPVTLDVLHQIFSKFGAVLKIITFTKNNQFQALLQYGDPVN 230

  Fly   569 AQHAKSLLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALP--PGEPGVDIMPTAGGL 631
            ||.||..||||||||.|||||||.|||..||||||||||||:|.|.||  .|:|.:|  |.
Mouse   231 AQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTRPDLPSGDGQPALD--PA---- 289

  Fly   632 MNTNDLLLIAARQRPSLSVNGL---GAPGVLPPFALGLGTPLTGGYNNALPNLAAFSLANSGALQ 693
                    |||......|:.||   ..||.|.|.              |:||.||.:.|.:....
Mouse   290 --------IAAAFAKETSLLGLPVAAVPGALSPL--------------AIPNAAAAAAAAAAGRV 332

  Fly   694 TTAPAMRGYSNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAM 758
            .......|.:.||||||||||||||.:|||||||||||||||||||||||||||||:..|:.|||
Mouse   333 GMPGVSAGGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAM 397

  Fly   759 SHLDKLRLWGKPIRVMASKHQAVQLPKEGQPDAGLTRDYSQNPLHRFKKPGSKNYQNIYPPSATL 823
            :||:..:::||.|||..||||.||||:||..|.|||:|:..:||||||||||||:|||:||||||
Mouse   398 NHLNGQKMYGKIIRVTLSKHQTVQLPREGLDDQGLTKDFGNSPLHRFKKPGSKNFQNIFPPSATL 462

  Fly   824 HLSNIPSSCSEDDIKEAFTSNSFEVKAFKFFPKDRKMALLQLLSVEEAVLALIKMHNHQLSESNH 888
            ||||||.|.:|:|::..|.:....|||||||.:|.||||||:.:||||:.|||.:||:.|.|::|
Mouse   463 HLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQRDHKMALLQMATVEEAIQALIDLHNYNLGENHH 527

  Fly   889 LRVSFSKSNI 898
            ||||||||.|
Mouse   528 LRVSFSKSTI 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
heph	NP_001247399.1	hnRNP-L_PTB	366..898	CDD:273733	279/542 (51%)
		RRM1_PTBP1_like	368..448	CDD:241132	43/79 (54%)
		RRM2_PTBP1_like	516..611	CDD:241137	66/94 (70%)
		RRM3_PTBP1_like	705..778	CDD:240869	55/72 (76%)
		RRM4_PTBP1_like	822..897	CDD:240871	45/74 (61%)
Ptbp2	XP_006501794.1	hnRNP-L_PTB	57..537	CDD:273733	279/542 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839747
Domainoid	1	1.000	140	1.000	Domainoid score	I4742
eggNOG	1	0.900	-	-		E1_KOG1190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	521	1.000	Inparanoid score	I1252
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58575
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001151
OrthoInspector	1	1.000	-	-		otm43656
orthoMCL	1	0.900	-	-		OOG6_101075
Panther	1	1.100	-	-	O	PTHR15592
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X703
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760