Protein Alignment heph and ptbp2a

DIOPT Version :9

• Sequence 1: NP_001247399.1
• Gene: heph / 48571
• FlyBaseID: FBgn0011224
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: NP_001315358.1
• Gene: ptbp2a / 541437
• ZFINID: ZDB-GENE-050320-141
• Length: 512
• Species: Danio rerio
• Alignment Length: 587
• Identity: 285/587 - (48%)
• Similarity: 378/587 - (64%)
• Gaps: 98/587 - (16%)

  Fly   323 RGSDELLSQAAVMAPA------SDNNNQDLATKKAKLEPGTVLAGGIAKASKVIHLRNIPNESGE 381
            ||||||||.....:|:      ||..:....:||.::|...    |.|..|:|:|:|.:||:..|
Zfish    13 RGSDELLSGGMYNSPSSGLSSISDTTSNGSDSKKLRVEERV----GDAPPSRVLHIRKLPNDVSE 73

  Fly   382 ADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRELK 446
            |::||||:|||:|||:|.||||||||:|::.|.:|.:||:.|:...|.:|...||:|:|||:|||
Zfish    74 AEIIALGLPFGKVTNILTLKGKNQAFLELSTEEAAMTMVNYYSAVTPHVRSVPVYIQYSNHKELK 138

  Fly   447 TDQGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNTNA 511
            ||                             |::.:...|:|.|||:.|             :.:
Zfish   139 TD-----------------------------NSSQSGGTSTSGSNSSDG-------------SGS 161

  Fly   512 AGGPNTVLRVIVESLMYPVSLDILHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSLL 576
            |..|  |||:|::::.|||:||:|.|||.::|.|:||:||||||.||||:||.|...||.||..|
Zfish   162 ASSP--VLRIIIDNMFYPVTLDVLQQIFSKFGTVMKIITFTKNNQFQALLQYNDPACAQQAKVAL 224

  Fly   577 DGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALP--PGEPGVDIMPTAGGLMNTNDLLL 639
            |||||||.|||||||.|||..||||||||||||:|.|.||  .|:|.:|:
Zfish   225 DGQNIYNACCTLRIDYSKLVNLNVKYNNDKSRDYTRPELPAGDGQPALDV--------------- 274

  Fly   640 IAARQRPSLSVNGLGAPGVLPPFALGLGTPLTGGYNNALPNLAAFSLANSGALQTTAPAMRGYSN 704
            .||..:.|.|:.| ..||.|.|.                 :.||.:.|.:|.:     |:.|:|:
Zfish   275 AAALSKDSSSLLG-KIPGALSPL-----------------SAAAAAAAAAGRV-----ALSGHSS 316

  Fly   705 ---VLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAMSHLDKLRL 766
               ||||||||||||||.:|||||||||||||||||:|||||||||||:..||.||||||:..::
Zfish   317 SGGVLLVSNLNEEMVTPHSLFTLFGVYGDVQRVKILFNKKDSALIQMADMNQAQLAMSHLNGQKM 381

  Fly   767 WGKPIRVMASKHQAVQLPKEGQPDAGLTRDYSQNPLHRFKKPGSKNYQNIYPPSATLHLSNIPSS 831
            :.|.|||..||||.||||::|..|.|||:|::.:||||||||||||:|||:||||||||||||..
Zfish   382 FSKIIRVTMSKHQTVQLPRDGLDDQGLTKDFTNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPQD 446

  Fly   832 CSEDDIKEAFTSNSFEVKAFKFFPKDRKMALLQLLSVEEAVLALIKMHNHQLSESNHLRVSFSKS 896
            .:|:|::..|:::...||||||| :|.||||:|:.::|||:..||.:||:.:..::||:||||||
Zfish   447 VTEEDLRVLFSNSGGTVKAFKFF-QDHKMALIQMSTIEEAIQCLIDLHNYNMGNNHHLKVSFSKS 510

  Fly   897 NI 898
            .|
Zfish   511 TI 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
heph	NP_001247399.1	hnRNP-L_PTB	366..898	CDD:273733	268/536 (50%)
		RRM1_PTBP1_like	368..448	CDD:241132	43/79 (54%)
		RRM2_PTBP1_like	516..611	CDD:241137	64/94 (68%)
		RRM3_PTBP1_like	705..778	CDD:240869	55/72 (76%)
		RRM4_PTBP1_like	822..897	CDD:240871	38/74 (51%)
ptbp2a	NP_001315358.1	hnRNP-L_PTB	58..512	CDD:273733	268/536 (50%)
		RRM1_PTBP1_like	60..140	CDD:241132	43/79 (54%)
		RRM2_PTBP1_like	165..259	CDD:241137	65/95 (68%)
		RRM_SF	307..412	CDD:302621	71/109 (65%)
		RRM4_PTBP2	433..512	CDD:241146	43/79 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583830
Domainoid	1	1.000	140	1.000	Domainoid score	I4697
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	527	1.000	Inparanoid score	I1195
OMA	1	1.010	-	-		QHG58575
OrthoDB	1	1.010	-	-		D1545178at2759
OrthoFinder	1	1.000	-	-		FOG0001151
OrthoInspector	1	1.000	-	-		otm25002
orthoMCL	1	0.900	-	-		OOG6_101075
Panther	1	1.100	-	-	O	PTHR15592
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X703
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910