DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment heph and ptbp1

DIOPT Version :9

Sequence 1:	NP_001247399.1	Gene:	heph / 48571	FlyBaseID:	FBgn0011224	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001011140.1	Gene:	ptbp1 / 496557	XenbaseID:	XB-GENE-5818206	Length:	554	Species:	Xenopus tropicalis

Alignment Length:	596	Identity:	317/596 - (53%)
Similarity:	398/596 - (66%)	Gaps:	75/596 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 RGSDELLSQAA----VM--APASDN----NNQDLATKKAKLEPGTVLAGGIAKASKVIHLRNIPN 377
            ||||||.|...    :|  |.|.:|    |..|  :||.|.:..:|..|     |:|||:|.:|.
Frog    14 RGSDELFSCVTNGPFIMSNATAGENLYGSNGND--SKKFKGDSRSVAVG-----SRVIHVRKLPG 71

  Fly   378 ESGEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNH 442
            :..||:||:||:|||:|||:|:||||||||:||..|.:|.:|::.||...|.:|.:.:|:|:|||
Frog    72 DVTEAEVISLGLPFGKVTNLLMLKGKNQAFLEMNTEEAANTMINYYTNVAPVLRSQPIYIQYSNH 136

  Fly   443 RELKTDQGHNNSTAHSD-YSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAG 506
            :|||||...|.:.|.:. .:|.|..||: ..|||:|                       :||:||
Frog   137 KELKTDNSPNQARAQAALQAVNSVVSGT-TALSASA-----------------------AAVDAG 177

  Fly   507 GNTNAAGGPNTVLRVIVESLMYPVSLDILHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQH 571
               .|..|.:.|||:|||:|.|||:||:|.|||.::|.||||:||||||.||||:||.|..||||
Frog   178 ---MAMSGQSPVLRIIVENLFYPVTLDVLQQIFSKFGTVLKIITFTKNNQFQALLQYGDPVSAQH 239

  Fly   572 AKSLLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALP--PGEPGVDIMPTAGGLMNT 634
            ||..||||||||.|||||||.||||:||||||||||||:|.|.||  .|:|.:|
Frog   240 AKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTRPDLPSGDGQPSLD----------- 293

  Fly   635 NDLLLIAARQRPSL-SVNGLGAPGVLPPFALGLG-----TPLTGGYNNALPN-LAAFSLANSGAL 692
               ..|||...|.| |.|...:.|..|.||:..|     .||      |||: .||.:.|.:|.|
Frog   294 ---QTIAAFGAPGLISANPYASAGFPPAFAIPQGVHGTLAPL------ALPSAAAAAAAAAAGRL 349

  Fly   693 QTTAPAMRGYSNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLA 757
            ......:.| ::||||||||.|.|||..||.||||||||.|||||:|||::||:|||:..||.||
Frog   350 GIPGLGIPG-NSVLLVSNLNPERVTPQCLFILFGVYGDVHRVKILFNKKENALVQMADGNQAQLA 413

  Fly   758 MSHLDKLRLWGKPIRVMASKHQAVQLPKEGQPDAGLTRDYSQNPLHRFKKPGSKNYQNIYPPSAT 822
            ||||:..||.|||:|:..||||.||||:|||.|.|||:|||.:||||||||||||:|||:|||||
Frog   414 MSHLNGQRLHGKPLRITVSKHQTVQLPREGQEDQGLTKDYSTSPLHRFKKPGSKNFQNIFPPSAT 478

  Fly   823 LHLSNIPSSCSEDDIKEAFTSNSFEVKAFKFFPKDRKMALLQLLSVEEAVLALIKMHNHQLSESN 887
            |||||||.|.||:|:|..|::|.:.||.||||.|||||||:|:.|||||:.:||::|||.:.|::
Frog   479 LHLSNIPPSVSEEDLKMLFSNNGYTVKGFKFFQKDRKMALIQMGSVEEAIESLIELHNHDMGENH 543

  Fly   888 HLRVSFSKSNI 898
            |||||||||.|
Frog   544 HLRVSFSKSTI 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
heph	NP_001247399.1	hnRNP-L_PTB	366..898	CDD:273733	298/541 (55%)
		RRM1_PTBP1_like	368..448	CDD:241132	43/79 (54%)
		RRM2_PTBP1_like	516..611	CDD:241137	71/94 (76%)
		RRM3_PTBP1_like	705..778	CDD:240869	50/72 (69%)
		RRM4_PTBP1_like	822..897	CDD:240871	48/74 (65%)
ptbp1	NP_001011140.1	hnRNP-L_PTB	61..554	CDD:273733	298/540 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I4672
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49188
Inparanoid	1	1.050	537	1.000	Inparanoid score	I1168
OMA	1	1.010	-	-		QHG58575
OrthoDB	1	1.010	-	-		D1545178at2759
OrthoFinder	1	1.000	-	-		FOG0001151
OrthoInspector	1	1.000	-	-		otm48825
Panther	1	1.100	-	-	LDO	PTHR15592
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X703
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080