DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment heph and hnrnpl

DIOPT Version :9

Sequence 1:	NP_001247399.1	Gene:	heph / 48571	FlyBaseID:	FBgn0011224	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_957393.1	Gene:	hnrnpl / 394074	ZFINID:	ZDB-GENE-040426-710	Length:	536	Species:	Danio rerio

Alignment Length:	618	Identity:	162/618 - (26%)
Similarity:	259/618 - (41%)	Gaps:	146/618 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 MAPASDNNNQD--LATKKAKLEPGTVLAGGIAKASK-----VIHLRNIPNESGEADVIALGIPFG 392
            ||.|:.:...|  .|||:.|.:...:...|.....|     |:|:|.:.:...|||::.....||
Zfish     1 MAAAAGHYYGDGGRATKRQKTDSDGMDTEGYNDPHKTLPSLVVHVRGLIDGITEADLVEALQEFG 65

  Fly   393 RVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRELKTDQGHNNSTAH 457
            .::.|:::..|.||.:|..|...|::.|:........:.||..|:.:|
Zfish    66 TISYVVLMPKKRQALVEFEDMNGASNAVTYANNNQIYIAGRPSYINYS----------------- 113

  Fly   458 SDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNTNAAGGPNTVLRVI 522
                                  ||...:..:||:....:                   |.||.:.
Zfish   114 ----------------------TSQKISRPTDSDDTRSV-------------------NNVLLLT 137

  Fly   523 VESLMYPVSLDILHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSLLDGQNIYNGCCT 587
            :.:.:||::.|:|:.|....|.|.:||.|.| |..||::::....|||.||:.|:|.:||:||||
Zfish   138 IMNPIYPITSDVLYTICNNCGPVQRIVIFRK-NGVQAMVEFDSVQSAQRAKASLNGADIYSGCCT 201

  Fly   588 LRIDNSKLTALNVKYNNDKSRDFTNPALPPGEPGVDIMPTAGGLMNTNDLLLIA-ARQR-PSL-- 648
            |:|:.:|.|.|||..|:..:.|:|||.|...:...|     |...|:.|..... .||| |:|
Zfish   202 LKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQDADAD-----GNWNNSQDPNANPNKRQRQPALLG 261

  Fly   649 -------SVNG--------LGAP---------GVLPPFALGLGTPLTGG--YNNALPNLAAFSLA 687
                   |..|        .|.|         .:.||...|.|.|..||  |.:..|
Zfish   262 DHPPEYGSPQGGYGHYDDTYGPPPPPPHYEGRRMGPPIGRGRGVPRYGGAQYGHGPP-------- 318

  Fly   688 NSGALQTTAPAMRGY--SNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAE 750
                    .|....:  |.|::|..|:...:..|.:|.:|.:||:|:|||.:.:|..:|:::|.:
Zfish   319 --------PPDYNAHADSPVVMVYGLDPVKINADRVFNIFCLYGNVERVKFMKSKPGAAMVEMGD 375

  Fly   751 PQQAYLAMSHLDKLRLWGKPIRVMASKHQAVQLPKEGQPDAGLT--RDYSQNPLHRF--KKPGSK 811
            ......|:|||:...|:|:.:.|..||.||:...:..|.:.|..  :|:.....:||  .:..:|
Zfish   376 CYAVDRAVSHLNNTMLFGQKLNVCVSKQQAIMPGQSYQLEDGSCSFKDFHGYRNNRFTTSEQAAK 440

  Fly   812 NYQNIYPPSATLHLSNI-PSS--------CSEDDIKEAFTSNSFEVKAFKFFPKDRKMA-LLQLL 866
            |  .|..||..||..|. |.|        |.|..||...:...|..|.      ||..: ||:..
Zfish   441 N--RIQQPSNVLHFFNSQPDSSVEAFSEICEELGIKSPVSVKLFTGKV------DRSSSGLLEWE 497

  Fly   867 SVEEAVLALIKMHNHQLSESN-----HLRVSFS 894
            ||.:|:.||..|:::|:...:     .|::.||
Zfish   498 SVNDAMEALALMNHYQMKNPSGPYPYTLKLCFS 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
heph	NP_001247399.1	hnRNP-L_PTB	366..898	CDD:273733	153/585 (26%)
		RRM1_PTBP1_like	368..448	CDD:241132	21/84 (25%)
		RRM2_PTBP1_like	516..611	CDD:241137	39/94 (41%)
		RRM3_PTBP1_like	705..778	CDD:240869	23/72 (32%)
		RRM4_PTBP1_like	822..897	CDD:240871	25/88 (28%)
hnrnpl	NP_957393.1	hnRNP-L_PTB	39..534	CDD:273733	152/580 (26%)
		RRM1_hnRNPL	39..118	CDD:241224	22/117 (19%)
		RRM2_hnRNPL	128..227	CDD:241229	40/118 (34%)
		Bindin	265..>322	CDD:251078	14/72 (19%)
		RRM_SF	330..403	CDD:302621	23/72 (32%)
		RRM4_hnRNPL	446..529	CDD:241148	25/88 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1545178at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920