Protein Alignment heph and HNRNPL

DIOPT Version :10

• Sequence 1: NP_001247399.1
• Gene: heph / 48571
• FlyBaseID: FBgn0011224
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: NP_001372580.1
• Gene: HNRNPL / 3191
• HGNCID: 5045
• Length: 626
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 151/597 - (25%)
• Similarity: 249/597 - (41%)
• Gaps: 144/597 - (24%)

  Fly   366 ASKVIHLRNIPNESGEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQM 430
            ||.|:|:|.:.:...|||::.....||.::.|:|:..|.||.:|..|.:.|.:.|: |..
Human   100 ASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVN-YAA----- 158

  Fly   431 RGRMVYVQFSNHRELKTDQGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMG 495
             ...:|:           .||   .|..:||                  ||...:...||:.:..
Human   159 -DNQIYI-----------AGH---PAFVNYS------------------TSQKISRPGDSDDSRS 190

  Fly   496 ILQNTSAVNAGGNTNAAGGPNTVLRVIVESLMYPVSLDILHQIFQRYGKVLKIVTFTKNNSFQAL 560
            :                   |:||...:.:.:|.::.|:|:.|....|.|.:||.|.| |..||:
Human   191 V-------------------NSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRK-NGVQAM 235

  Fly   561 IQYPDANSAQHAKSLLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALP-PGEPGVDI 624
            :::....|||.||:.|:|.:||:|||||:|:.:|.|.|||..|:..:.|:|||.|. .|:||
Human   236 VEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPG--- 297

  Fly   625 MPTAGGLMNTNDLLLIAARQR------------------PSLSVNGLGAPGVLPPFALGLGTPL- 670
                   .|.|      .|||                  ||:...|..||...||.......||
Human   298 -------SNPN------KRQRQPPLLGDHPAEYGEGRGFPSVDSRGSCAPARRPPCKFSPVLPLF 349

  Fly   671 --------TGGYNNAL---------PNLAAFSLANSGALQTTAPAMRG--------------Y-- 702
                    .|||::..         |:.....:..........|:..|              |
Human   350 PSHPPGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPEYGP 414

  Fly   703 ---SNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAMSHLDKL 764
               |.||:|..|::..:..|.:|.:|.:||:|::||.:.:|..:|:::||:......|::||:..
Human   415 HADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNN 479

  Fly   765 RLWGKPIRVMASKHQAVQLPKE--GQPDAGLT-RDYSQNPLHRFKKPGSKNYQNIYPPSATLHLS 826
            .::|:.:.|..||..|: :|.:  |..|...: :|:|::..:||..|.......|..||..||..
Human   480 FMFGQKLNVCVSKQPAI-MPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFF 543

  Fly   827 NIPSSCSEDDI----KEAFTSNSFEVKAFKFFPKDRKMALLQLLSVEEAVLALIKMHNHQLSESN 887
            |.|...:|::.    .|........||.|....:.....||:..|..:|:..|..::::|:...|
Human   544 NAPLEVTEENFFEICDELGVKRPSSVKVFSGKSERSSSGLLEWESKSDALETLGFLNHYQMKNPN 608

  Fly   888 -----HLRVSFS 894
                 .|::.||
Human   609 GPYPYTLKLCFS 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
heph	NP_001247399.1	hnRNP-L_PTB	366..898	CDD:273733	151/597 (25%)
HNRNPL	NP_001372580.1	hnRNP-L_PTB	100..624	CDD:273733	151/597 (25%)