DRSC/TRiP Functional Genomics Resources

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Protein Alignment heph and RBM20

DIOPT Version :10

Sequence 1:NP_001247399.1 Gene:heph / 48571 FlyBaseID:FBgn0011224 Length:898 Species:Drosophila melanogaster
Sequence 2:NP_001127835.2 Gene:RBM20 / 282996 HGNCID:27424 Length:1227 Species:Homo sapiens


Alignment Length:664 Identity:138/664 - (20%)
Similarity:226/664 - (34%) Gaps:219/664 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 PIPMPMPISSLHKSEFEPVNIGVKQMQLLHAPASTHPHPHPHQHPQHSAASAAAYQAMQVHQQ-- 67
            |.|.|.|          |...|:.|: :.:|......:|....:|.....|.|:.|..|:..|  
Human    46 PPPQPPP----------PPQAGLPQI-IQNAAKLLDKNPFSVSNPNPLLPSPASLQLAQLQAQLT 99

  Fly    68 -QHQQQQQAAVFHHQVAAIAAQQ------QQQQQQAQVQHQQQMQQQFHYQAQAQAQAQAMLQTY 125
             ...:..|.||.::..||....|      ..|....|::|...:... |..|.....|.|:..|.
Human   100 LHRLKLAQTAVTNNTAAATVLNQVLSKVAMSQPLFNQLRHPSVITGP-HGHAGVPQHAAAIPSTR 163

  Fly   126 MQLQVNSAVGVSTAPAT----PTKPVAAQIPGA-ISGPIAGPVPVSVPTQFFTAPSTPLTII--- 182
            ..   ::|:..|....|    |:..:..|.|.| :..|..|.:|        ..|..|..|:   
Human   164 FP---SNAIAFSPPSQTRGPGPSMNLPNQPPSAMVMHPFTGVMP--------QTPGQPAVILGIG 217

  Fly   183 ---PAAAVASSAMFATAAT---------------PTSAATT------------------------ 205
               ||.|.|....:..|::               |:||:|:                        
Human   218 KTGPAPATAGFYEYGKASSGQTYGPETDGQPGFLPSSASTSGSVTYEGHYSHTGQDGQAAFSKDF 282

  Fly   206 --PTNNVNNTVN------------------------------LSAVSRTTTTTTKKQP------- 231
              |.:..::..:                              .|..|:...|.....|       
Human   283 YGPNSQGSHVASGFPAEQAGGLKSEVGPLLQGTNSQWESPHGFSGQSKPDLTAGPMWPPPHNQPY 347

  Fly   232 ------QAVADAVLSAVGGNVGTA----VGGGTIS----SLLGPEPLP---------IMPHHLP- 272
                  :..:|....:.||.:..:    :|.|..:    :||...||.         :.|.||| 
Human   348 ELYDPEEPTSDRTPPSFGGRLNNSKQGFIGAGRRAKEDQALLSVRPLQAHELNDFHGVAPLHLPH 412

  Fly   273 LAS---------------VRG------C----SSASSGCSSASSD---CSMPSPTSLHLSSPKKV 309
            :.|               |:|      |    .:|...|...|::   |:.|:.|:::  :|.. 
Human   413 ICSICDKKVFDLKDWELHVKGKLHAQKCLVFSENAGIRCILGSAEGTLCASPNSTAVY--NPAG- 474

  Fly   310 RIDEQYIYKL--NYLRGSDELLSQAAVMAPASDNNNQDLATKKAKLEPGTVLA---GGIAKASKV 369
              :|.|...|  :|:.......:|::...|.:              ..||..|   |    |.:|
Human   475 --NEDYASNLGTSYVPIPARSFTQSSPTFPLA--------------SVGTTFAQRKG----AGRV 519

  Fly   370 IHLRNIPNES-GEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGR 433
            :|:.|:|..| .|.|||.||:|||:|||.:::|..||||:|||...:|.:||..|......:.|.
Human   520 VHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYTEAAQAMVQYYQEKSAVINGE 584

  Fly   434 MVYVQFS-NHRELKTDQGHNNSTA-----HSD-----------YSVQSPASGSPLPLSAAANATS 481
            .:.::.| .::||:..:......|     ||.           |..:.|.|.||:..|.:..:.:
Human   585 KLLIRMSKRYKELQLKKPGKAVAAIIQDIHSQRERDMFREADRYGPERPRSRSPVSRSLSPRSHT 649

  Fly   482 NNANSSSDSNSAMG 495
            .:..|.|.|:|..|
Human   650 PSFTSCSSSHSPPG 663

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hephNP_001247399.1 hnRNP-L_PTB 366..898 CDD:273733 48/148 (32%)
RBM20NP_001127835.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58 5/21 (24%)
PTZ00395 185..>362 CDD:185594 24/184 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 289..374 7/84 (8%)
RRM_RBM20 518..593 CDD:410086 31/74 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 624..906 11/40 (28%)
RS. /evidence=ECO:0000305|PubMed:23886709 628..655 6/26 (23%)
PTZ00121 <682..941 CDD:173412
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 977..1089
ZnF_U1 1159..1193 CDD:197732
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1201..1227
Blue background indicates that the domain is not in the aligned region.

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