Protein Alignment heph and Ptbp1

DIOPT Version :10

• Sequence 1: NP_001247399.1
• Gene: heph / 48571
• FlyBaseID: FBgn0011224
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: NP_001070831.1
• Gene: Ptbp1 / 19205
• MGIID: 97791
• Length: 555
• Species: Mus musculus
• Alignment Length: 602
• Identity: 325/602 - (53%)
• Similarity: 398/602 - (66%)
• Gaps: 86/602 - (14%)

  Fly   323 RGSDELLSQAAVMAP------ASDNNNQDLATKKAKLEPGTVLAGGIAKASKVIHLRNIPNESGE 381
            ||||||.|......|      ||..|..|  :||.|   |...:.|:  .|:|||:|.:|::..|
Mouse    14 RGSDELFSTCVSNGPFIMSSSASAANGND--SKKFK---GDNRSAGV--PSRVIHVRKLPSDVTE 71

  Fly   382 ADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRELK 446
            .:||:||:|||:|||:|:|||||||||||..|.:|.:||:.||...|.:||:.:|:|||||:|||
Mouse    72 GEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVAPVLRGQPIYIQFSNHKELK 136

  Fly   447 TDQGHNNSTAHSD-YSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNTN 510
            ||...|.:.|.:. .:|.|..||:   |:.||:|                     :||:||   .
Mouse   137 TDSSPNQARAQAALQAVNSVQSGN---LALAASA---------------------AAVDAG---M 174

  Fly   511 AAGGPNTVLRVIVESLMYPVSLDILHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSL 575
            |..|.:.|||:|||:|.|||:||:|||||.::|.||||:||||||.||||:||.|..||||||..
Mouse   175 AMAGQSPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLS 239

  Fly   576 LDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALPPGEPGVDIMPTAGGLMNTNDLLLI 640
            ||||||||.|||||||.||||:||||||||||||:|.|.||.|    |..|:.       |..:.
Mouse   240 LDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTRPDLPSG----DSQPSL-------DQTMA 293

  Fly   641 AARQRPSLSVNGLGAPGVL--PPFALGLGTPLTGGYNNALPNLAAFSLAN-SGALQTTA------ 696
            ||          .||||::  .|:| |.|.|.|    .|:|..|..|:.| .|||...|
Mouse   294 AA----------FGAPGIMSASPYA-GAGFPPT----FAIPQAAGLSVPNVHGALAPLAIPSAAA 343

  Fly   697 ---------PAMRGYSN-VLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEP 751
                     |.:.|..| ||||||||.|.|||.:||.||||||||||||||:|||::||:|||:.
Mouse   344 AAAASRIAIPGLAGAGNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVKILFNKKENALVQMADG 408

  Fly   752 QQAYLAMSHLDKLRLWGKPIRVMASKHQAVQLPKEGQPDAGLTRDYSQNPLHRFKKPGSKNYQNI 816
            .||.||||||:..:|.||.:|:..||||:||||:|||.|.|||:||..:||||||||||||:|||
Mouse   409 SQAQLAMSHLNGHKLHGKSVRITLSKHQSVQLPREGQEDQGLTKDYGSSPLHRFKKPGSKNFQNI 473

  Fly   817 YPPSATLHLSNIPSSCSEDDIKEAFTSNSFEVKAFKFFPKDRKMALLQLLSVEEAVLALIKMHNH 881
            :||||||||||||.|.||||:|..|:||...||.||||.|||||||:|:.||||||.|||::|||
Mouse   474 FPPSATLHLSNIPPSVSEDDLKSLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIELHNH 538

  Fly   882 QLSESNHLRVSFSKSNI 898
            .|.|::|||||||||.|
Mouse   539 DLGENHHLRVSFSKSTI 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
heph	NP_001247399.1	hnRNP-L_PTB	366..898	CDD:273733	307/551 (56%)
Ptbp1	NP_001070831.1	hnRNP-L_PTB	56..555	CDD:273733	307/551 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	435..457		15/21 (71%)