DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment heph and ptb-1

DIOPT Version :9

Sequence 1:	NP_001247399.1	Gene:	heph / 48571	FlyBaseID:	FBgn0011224	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_741041.1	Gene:	ptb-1 / 174647	WormBaseID:	WBGene00004207	Length:	615	Species:	Caenorhabditis elegans

Alignment Length:	676	Identity:	309/676 - (45%)
Similarity:	409/676 - (60%)	Gaps:	102/676 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 GPEPLPIMPHHLPLASVRGCSSASSGCSSASSDCSMPSPTSLHLSSPKKVRID------EQYIYK 318
            ||:.|.:...:    .|.|.|:.:.|.::|:...::.:..    |.|||.::|      :.|...
Worm     5 GPDDLQLSLRN----GVGGASTTAPGVAAAAYYANVMTAD----SEPKKAKLDPTLYSSQFYTPA 61

  Fly   319 LNYLRGSDELLSQAAVMAPASDNNNQDLA----TKKAKLEPGTVLAGGIAKA------SKVIHLR 373
            :::...:.:..:.|||.|.|:....|.|.    |:...::..|:.......|      |||:|:|
Worm    62 MHHGLMTADASTVAAVTAAANATTAQLLTGNPITQIQGIQLSTLPQCNSTSAVTSIPVSKVVHVR 126

  Fly   374 NIPNESGEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQ 438
            |||.:..:.:::.|.|.:|.|:|.::||||:|||:|..:|.||.:.||..|..|.|:|||.::.|
Worm   127 NIPPDLVDVELMQLCIQYGPVSNYMMLKGKSQAFVEYEEEASAAAFVSGMTAVPIQIRGRTLFAQ 191

  Fly   439 FSNHRELKTDQGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAV 503
            :|.|||||.|:    :.|.||  .:|.|:||.                   ||..:|..|.
Worm   192 YSTHRELKFDK----NKAISD--TESVANGSV-------------------SNFEVGTQQQ---- 227

  Fly   504 NAGGNTNAAGGPNTVLRVIVESLMYPVSLDILHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANS 568
                       ||:|||.|:|::|:|||||:|:|:|.||||||:|:||.|||:||||:|..:|||
Worm   228 -----------PNSVLRTIIENMMFPVSLDVLYQLFTRYGKVLRIITFNKNNTFQALVQMSEANS 281

  Fly   569 AQHAKSLLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALPPGE-----------PGV 622
            ||.||..|:.||:||||||||||.|||:.||||||||||||:|||.||.||           ||:
Worm   282 AQLAKQGLENQNVYNGCCTLRIDYSKLSTLNVKYNNDKSRDYTNPNLPAGEMTLEQTIAMSIPGL 346

  Fly   623 -DIMPT-----AGGLMNTNDLLL--IAARQRPSLSVNGLGAPGVLPPFALGLGTPLTGGYNNALP 679
             :::|.     |.|.......|.  :||....:.:||.......|.|:...||  ||..  |..|
Worm   347 QNLIPANPYNFAFGANPATTFLTTQLAASTAAAAAVNDSANAAALAPYLNPLG--LTSA--NLAP 407

  Fly   680 NLAA--FSLANSGALQTTAPAMRGYSNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKD 742
            ::::  |.:.|             .:.|:|||||:|..||.|||||||||||||.||||||||||
Worm   408 SISSMRFPMIN-------------LTPVILVSNLHEMKVTTDALFTLFGVYGDVMRVKILYNKKD 459

  Fly   743 SALIQMAEPQQAYLAMSHLDKLRLWGKPIRVMASKHQAVQLPKEGQPDAGLTRDYSQNPLHRFKK 807
            :||||.:|||||.||::||||::...:.|||..|||..||:||||||||||||||:.:.||||||
Worm   460 NALIQYSEPQQAQLALTHLDKVKWHDRLIRVAPSKHTNVQMPKEGQPDAGLTRDYAHSTLHRFKK 524

  Fly   808 PGSKNYQNIYPPSATLHLSNIPSSCSEDDIKEAFTSNSFEVKAFKFFPKDRKMALLQLLSVEEAV 872
            ||||||.|||||.|||||||||:|.||:.:||.|....|.||||||||||.||||.||..:|.|:
Worm   525 PGSKNYLNIYPPCATLHLSNIPTSVSEEKLKEMFAEAGFAVKAFKFFPKDHKMALCQLEDIETAI 589

  Fly   873 LALIKMHNHQLSESNHLRVSFSKSNI 898
            .|||.||||:|:|:.|||||||||.|
Worm   590 DALIAMHNHKLAENAHLRVSFSKSGI 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
heph	NP_001247399.1	hnRNP-L_PTB	366..898	CDD:273733	285/558 (51%)
		RRM1_PTBP1_like	368..448	CDD:241132	38/79 (48%)
		RRM2_PTBP1_like	516..611	CDD:241137	67/94 (71%)
		RRM3_PTBP1_like	705..778	CDD:240869	51/72 (71%)
		RRM4_PTBP1_like	822..897	CDD:240871	50/74 (68%)
ptb-1	NP_741041.1	hnRNP-L_PTB	119..615	CDD:273733	284/552 (51%)
		RRM1_PTBP1_hnRNPL_like	122..195	CDD:240867	32/72 (44%)
		RRM2_PTBP1_like	229..324	CDD:241137	67/94 (71%)
		RRM3_PTBP1_like	422..495	CDD:240869	51/72 (71%)
		RRM4_PTBP1_like	539..613	CDD:240871	49/73 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161115
Domainoid	1	1.000	138	1.000	Domainoid score	I3017
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49188
Inparanoid	1	1.050	491	1.000	Inparanoid score	I777
Isobase	1	0.950	-	0	Normalized mean entropy	S2018
OMA	1	1.010	-	-		QHG58575
OrthoDB	1	1.010	-	-		D1545178at2759
OrthoFinder	1	1.000	-	-		FOG0001151
OrthoInspector	1	1.000	-	-		oto18473
orthoMCL	1	0.900	-	-		OOG6_101075
Panther	1	1.100	-	-	LDO	PTHR15592
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4107
SonicParanoid	1	1.000	-	-		X703
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890