DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment heph and ptbp3

DIOPT Version :9

Sequence 1:	NP_001247399.1	Gene:	heph / 48571	FlyBaseID:	FBgn0011224	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	XP_012811881.1	Gene:	ptbp3 / 100145652	XenbaseID:	XB-GENE-988703	Length:	530	Species:	Xenopus tropicalis

Alignment Length:	574	Identity:	288/574 - (50%)
Similarity:	366/574 - (63%)	Gaps:	76/574 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 ASDNNNQDLATKKAKLEPGTVLAGGIAKASKVIHLRNIPNESGEADVIALGIPFGRVTNVLVLKG 402
            |:.|:::.....::...|           |:|:|:|.|||:..|:::|:||:|||:|||:|:|||
Frog    20 ANGNDSKKFKGDRSPCSP-----------SRVLHIRKIPNDVTESEIISLGLPFGKVTNLLMLKG 73

  Fly   403 KNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRELKTDQGHNNSTAHSDYSVQSPAS 467
            |:|||:|||.|.:|.|||:.||..||.:|.:.||:|:|||||||||.
Frog    74 KSQAFLEMASEEAAVSMVNYYTPVPPHVRSQPVYIQYSNHRELKTDN------------------ 120

  Fly   468 GSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNTNAAGGPNTVLRVIVESLMYPVSL 532
               ||..|.|.|.....|:...     |.|..||.  .||......|.:.|||:|||:|.|||:|
Frog   121 ---LPNQARAQAALQAVNTLQS-----GGLTLTSV--PGGEGLVLSGQSPVLRIIVENLFYPVTL 175

  Fly   533 DILHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSLLDGQNIYNGCCTLRIDNSKLTA 597
            ::|||||.::|.|:||:||||||.||||:||.|..:|.|||..||||||||.||||||:.||||:
Frog   176 EVLHQIFSKFGTVIKIITFTKNNQFQALLQYADPMNAHHAKVALDGQNIYNACCTLRIEFSKLTS 240

  Fly   598 LNVKYNNDKSRDFTNPALP--PGEPGVDIMPTAGGLMNTNDLLLIAARQRPSLSVNGLGAPGVLP 660
            ||||||||||||||...||  .|:|.:|....|                       ..||||::.
Frog   241 LNVKYNNDKSRDFTRLDLPTGDGQPSLDTTMAA-----------------------AFGAPGIIS 282

  Fly   661 P-------FALGLGTPLTGGYNNALPNLAAFSLANSGALQTTA----PAMRGYSNVLLVSNLNEE 714
            .       ||..:|.|..|.....:|.|...:|..|......|    .|:.|:| ||||||||.:
Frog   283 SPYAGAAGFAPAIGFPQAGLSVPGVPGLGPLALTTSAITGRMAIPGMTAIPGHS-VLLVSNLNPD 346

  Fly   715 MVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAMSHLDKLRLWGKPIRVMASKHQ 779
            .:.|..||.||||||||||||||:|||::||:||.:..||.||||||:..||.|:.:|:..||||
Frog   347 AILPHGLFILFGVYGDVQRVKILFNKKENALVQMTDATQAQLAMSHLNGQRLHGRVLRITLSKHQ 411

  Fly   780 AVQLPKEGQPDAGLTRDYSQNPLHRFKKPGSKNYQNIYPPSATLHLSNIPSSCSEDDIKEAFTSN 844
            :||||:||..|.|||:||:.:||||||||||||:|||:||||||||||||...:::|:|..|.|.
Frog   412 SVQLPREGHEDQGLTKDYTNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPLVTDEDLKRLFAST 476

  Fly   845 SFEVKAFKFFPKDRKMALLQLLSVEEAVLALIKMHNHQLSESNHLRVSFSKSNI 898
            ...||.||||.|||||||:||.|||||:||||::|||.|.|::|||||||||.|
Frog   477 GCSVKGFKFFQKDRKMALIQLGSVEEAILALIELHNHDLGENHHLRVSFSKSMI 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
heph	NP_001247399.1	hnRNP-L_PTB	366..898	CDD:273733	284/544 (52%)
		RRM1_PTBP1_like	368..448	CDD:241132	47/79 (59%)
		RRM2_PTBP1_like	516..611	CDD:241137	67/94 (71%)
		RRM3_PTBP1_like	705..778	CDD:240869	45/72 (63%)
		RRM4_PTBP1_like	822..897	CDD:240871	49/74 (66%)
ptbp3	XP_012811881.1	hnRNP-L_PTB	37..530	CDD:273733	285/555 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I4672
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	537	1.000	Inparanoid score	I1168
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1545178at2759
OrthoFinder	1	1.000	-	-		FOG0001151
OrthoInspector	1	1.000	-	-		otm48825
Panther	1	1.100	-	-	O	PTHR15592
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4107
SonicParanoid	1	1.000	-	-		X703
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.190