Protein Alignment NOVA1 and Imp

DIOPT Version :10

• Sequence 1: NP_002506.2
• Gene: NOVA1 / 4857
• HGNCID: 7886
• Length: 507
• Species: Homo sapiens
• Sequence 2: NP_001245616.1
• Gene: Imp / 32009
• FlyBaseID: FBgn0285926
• Length: 638
• Species: Drosophila melanogaster
• Alignment Length: 508
• Identity: 113/508 - (22%)
• Similarity: 184/508 - (36%)
• Gaps: 146/508 - (28%)

Human    20 LDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIK 84
            ||....|.:..:..|..|   ....|....:.|::|:.|...|:|||:.|.||..:.:::.|.:.
  Fly   116 LDKNQRRSQRNQRNPYPG---MPGPGRQADFPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVD 177

Human    85 LSKSKDFYPGTTERVCLIQGTVEALNAVHGFIAEKIREMPQNVAKTEPVSILQPQTTVNP-DRIK 148
            :.:.::.            |::|....::|                      .|:...|. .||.
  Fly   178 VHRKENV------------GSLEKSITIYG----------------------NPENCTNACKRIL 208

Human   149 QTLPSSPTTTKSSPSDPMTTSRANQVKIIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPD- 212
            :.:.....:|......|..:...  :||:..|:..|.||||.|.|:|.:|:.:...:.:|...|
  Fly   209 EVMQQEAISTNKGELSPECSEIC--LKILAHNNLIGRIIGKSGNTIKRIMQDTDTKITVSSINDI 271

Human   213 -GINLQERVVTVSGEPEQNRKAVELIIQKIQE----DPQSGSCLNISYANVTGPVANSNPTGSPY 272
             ..|| ||::||.|..|...:|...|..|:::    |.|:.:..::.:..:......|.|.....
  Fly   272 NSFNL-ERIITVKGLIENMSRAENQISTKLRQSYENDLQAMAPQSLMFPGLHPMAMMSTPGNGMV 335

Human   273 ANTAEVLPTAAAAAGLLGHANLAGVAAFPA-VLSGFTGNDLVAITSALNTLASYGYNLNTLGLGL 336
            .||:...|:..:.|          ::..|| |:.....|||...|        |.|..|.
  Fly   336 FNTSMPFPSCQSFA----------MSKTPASVVPPVFPNDLQETT--------YLYIPNN----- 377

Human   337 SQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGT-------FALGSLAAATAA 394
                |.||:.                               ||.|:       |:..||..|.
  Fly   378 ----AVGAII-------------------------------GTRGSHIRSIMRFSNASLKIAP-- 405

Human   395 TNGYFGAASPLAAS-----AILGT------------EKSTD-----GSKDV---VEIAVPENLVG 434
                ..|..||...     .|:||            ||..:     |:.||   ||:.|..:.||
  Fly   406 ----LDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMREEGFMCGTDDVRLTVELLVASSQVG 466

Human   435 AILGKGGKTLVEYQELTGARIQISKKGEFVP--GTRNRKVTITGTPAATQAAQ 485
            .|:||||:.:.|.|.:||:.|::.:.....|  |.....|.|.|...:.|:||
  Fly   467 RIIGKGGQNVRELQRVTGSVIKLPEHALAPPSGGDEETPVHIIGLFYSVQSAQ 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NOVA1	NP_002506.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		5/23 (22%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	27..43		2/15 (13%)
		KH-I_NOVA_rpt1	49..121	CDD:411863	14/71 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..171		5/32 (16%)
		KH-I_NOVA_rpt2	172..241	CDD:411864	24/70 (34%)
		Required for RNA binding. /evidence=ECO:0000269|PubMed:10811881	419..503		26/72 (36%)
		KH-I_NOVA_rpt3	422..492	CDD:411807	25/69 (36%)
Imp	NP_001245616.1	RRM2_VICKZ	42..118	CDD:409794	1/1 (100%)
		KH-I_IGF2BP_rpt1	144..211	CDD:411828	18/100 (18%)
		KH-I_IGF2BP_rpt2	231..302	CDD:411829	25/73 (34%)
		KH-I_IGF2BP_rpt3	368..437	CDD:411830	20/122 (16%)
		KH-I_IGF2BP_rpt4	455..523	CDD:411831	23/65 (35%)