DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sam-S and mat2al

DIOPT Version :9

Sequence 1:	NP_524923.1	Gene:	Sam-S / 48552	FlyBaseID:	FBgn0005278	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_001035469.1	Gene:	mat2al / 678634	ZFINID:	ZDB-GENE-060421-5255	Length:	390	Species:	Danio rerio

Alignment Length:	385	Identity:	263/385 - (68%)
Similarity:	323/385 - (83%)	Gaps:	0/385 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SYDMEDGATFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITS 84
            |..::.|.|||||||||||||.||||||||||:|||:|.|||:::||||.|:||||||||||:||
Zfish     4 SGQLKSGKTFLFTSESVGEGHSDKMCDQISDAVLDAYLTQDPDSRVACECVSKTGMILLCGEVTS 68

  Fly    85 KAVVDYQKVVRETVQHIGYDDSSKGFDWKTLNLLVAIEQQSPNIANGVHINREEEDVGAGDQGIM 149
            |||||.|:|||:||:.|||||||||||:||.|:||:::.|...|::.|...|:.||:||||||:|
Zfish    69 KAVVDLQRVVRDTVKTIGYDDSSKGFDYKTCNVLVSLQPQVSEISDCVFEGRDSEDIGAGDQGLM 133

  Fly   150 FGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSAVPKRVHTI 214
            |||||||||||||||::||||||.|:.||.::.|..|..||||||||.||..|.|:..|.||||:
Zfish   134 FGYATDETEECMPLTILLAHKLNYKMKELSKTGVCPWILPDSKTQVTVEYRDNMGAMEPVRVHTV 198

  Fly   215 VVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIV 279
            |:|:|||..|:||.:|..:||||||.||||||:|..||.|:.|.|.|::|||.||||||||||||
Zfish   199 VISVQHSPDITLEDIRHNLMEKVVKAVIPAKYLDDKTIYHLLPSGKFLLGGPQGDAGLTGRKIIV 263

  Fly   280 DTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVF 344
            |||||||.||||||||||::|||||.||||||||||||||.||:|.|||:|||||::.|||::||
Zfish   264 DTYGGWGGHGGGAFSGKDYSKVDRSGAYAARWVAKSLVKAKLCRRVLVQISYAIGISHPLSVSVF 328

  Fly   345 DYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPL 404
            .||||.:.:.:||:|:::|||||||.|||:|:|::||||:|:.||||||.||.||:.|.|
Zfish   329 HYGTSTRDEDDLLEIVKKNFDLRPGVIVKELDLKKPIYQKTACYGHFGREGFPWEKPKKL 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sam-S	NP_524923.1	PTZ00104	28..408	CDD:240268	261/377 (69%)
		S-AdoMet_synt_N	28..125	CDD:278846	74/96 (77%)
		S-AdoMet_synt_M	140..261	CDD:280867	78/120 (65%)
		S-AdoMet_synt_C	263..399	CDD:280868	99/135 (73%)
mat2al	NP_001035469.1	PTZ00104	11..388	CDD:240268	260/376 (69%)
		S-AdoMet_synt_N	12..108	CDD:278846	74/95 (78%)
		S-AdoMet_synt_M	124..245	CDD:280867	78/120 (65%)
		S-AdoMet_synt_C	247..383	CDD:280868	99/135 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580861
Domainoid	1	1.000	240	1.000	Domainoid score	I2212
eggNOG	1	0.900	-	-		E1_COG0192
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61243
OrthoDB	1	1.010	-	-		D357186at33208
OrthoFinder	1	1.000	-	-		FOG0000746
OrthoInspector	1	1.000	-	-		otm24268
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11964
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X478
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.820