DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sam-S and Mat1a

DIOPT Version :9

Sequence 1:	NP_524923.1	Gene:	Sam-S / 48552	FlyBaseID:	FBgn0005278	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_036992.2	Gene:	Mat1a / 25331	RGDID:	3050	Length:	396	Species:	Rattus norvegicus

Alignment Length:	381	Identity:	281/381 - (73%)
Similarity:	341/381 - (89%)	Gaps:	1/381 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EDGATFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVV 88
            |:|| |:|||||||||||||:|||||||:||||||||||||||||||.||||:||||||||.|::
  Rat    15 EEGA-FMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMI 78

  Fly    89 DYQKVVRETVQHIGYDDSSKGFDWKTLNLLVAIEQQSPNIANGVHINREEEDVGAGDQGIMFGYA 153
            |||:|||:|::|||||||:||||:||.|:|||:|||||:||..||::|.||||||||||:|||||
  Rat    79 DYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYA 143

  Fly   154 TDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSAVPKRVHTIVVSM 218
            |||||||||||:|||||||.::|:||||.|..|.|||||||||.:|:.:.|:.:|.||||||:|:
  Rat   144 TDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPDSKTQVTVQYVQDNGAVIPVRVHTIVISV 208

  Fly   219 QHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIVDTYG 283
            ||:|.|:||.:|..:.|:|:|.|:||||:|.:||.|:.|.|.||||||.||||:|||||||||||
  Rat   209 QHNEDITLEAMREALKEQVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYG 273

  Fly   284 GWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGT 348
            ||||||||||||||:||||||||||||||||||||||||:|.|||||||||:||||||::|.|||
  Rat   274 GWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGT 338

  Fly   349 SHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPL 404
            |.|:::|||:::.:|||||||.||:||:|::||||:|:.||||||:.|.||..|.|
  Rat   339 SKKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKL 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sam-S	NP_524923.1	PTZ00104	28..408	CDD:240268	278/377 (74%)
		S-AdoMet_synt_N	28..125	CDD:278846	78/96 (81%)
		S-AdoMet_synt_M	140..261	CDD:280867	78/120 (65%)
		S-AdoMet_synt_C	263..399	CDD:280868	106/135 (79%)
Mat1a	NP_036992.2	PTZ00104	17..394	CDD:240268	279/377 (74%)
Mat1a	NP_036992.2	Flexible loop. /evidence=ECO:0000250\|UniProtKB:P0A817	114..126		7/11 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340977
Domainoid	1	1.000	237	1.000	Domainoid score	I2250
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	602	1.000	Inparanoid score	I907
OMA	1	1.010	-	-		QHG61243
OrthoDB	1	1.010	-	-		D357186at33208
OrthoFinder	1	1.000	-	-		FOG0000746
OrthoInspector	1	1.000	-	-		otm46081
orthoMCL	1	0.900	-	-		OOG6_100388
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X478
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.810