Protein Alignment NOTCH4 and SET4

DIOPT Version :10

• Sequence 1: NP_004548.3
• Gene: NOTCH4 / 4855
• HGNCID: 7884
• Length: 2003
• Species: Homo sapiens
• Sequence 2: NP_012430.1
• Gene: SET4 / 853339
• SGDID: S000003641
• Length: 560
• Species: Saccharomyces cerevisiae
• Alignment Length: 12
• Identity: 8/12 - (66%)
• Similarity: 8/12 - (66%)
• Gaps: 0/12 - (0%)

Human   954 CQCAPGYDGQNC 965
            |.||.||.|.||
Yeast   514 CDCACGYLGHNC 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NOTCH4	NP_004548.3	EGF_CA	194..225	CDD:429571
		EGF	280..308	CDD:394967
		EGF_CA	314..353	CDD:238011
		EGF_CA	<364..390	CDD:238011
		EGF_CA	432..473	CDD:238011
		EGF_CA	475..511	CDD:238011
		EGF_CA	515..549	CDD:238011
		EGF_CA	551..587	CDD:238011
		EGF_CA	590..625	CDD:238011
		EGF_CA	<699..726	CDD:238011
		EGF_CA	<736..765	CDD:238011
		EGF_CA	769..803	CDD:238011
		EGF_CA	<813..842	CDD:238011
		EGF_CA	<899..928	CDD:238011
		EGF_CA	931..965	CDD:238011	6/10 (60%)
		EGF_CA	970..1004	CDD:238011
		EGF_CA	1047..1084	CDD:238011
		Notch	1168..1204	CDD:459658
		LNR 1	1170..1213
		Notch	1211..1246	CDD:459658
		LNR 2	1214..1250
		Notch	1249..1285	CDD:459658
		LNR 3	1251..1294
		NOD	1295..1344	CDD:462014
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1347..1371
		NODP	1379..>1420	CDD:462229
		JMTM_Notch4	1431..1515	CDD:411988
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1485..1508
		ANK repeat	1586..1630	CDD:293786
		ANKYR	<1619..1823	CDD:440430
		ANK 1	1633..1665
		ANK repeat	1634..1664	CDD:293786
		ANK repeat	1666..1698	CDD:293786
		ANK 2	1666..1698
		ANK 3	1700..1732
		ANK repeat	1700..1731	CDD:293786
		ANK 4	1733..1765
		ANK repeat	1733..1764	CDD:293786
		ANK 5	1766..1798
		ANK repeat	1766..1797	CDD:293786
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1900..1927
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1968..2003
SET4	NP_012430.1	PHD_SF	163..207	CDD:473978
		SET_SpSET3-like	346..527	CDD:380960	8/12 (67%)